脑白质高信号与缺血性脑卒中关系的研究进展

Research Progress on the Relationship between White Matter Hyperintensity and Ischemic Stroke

摘要: 随着全球人口老龄化的加速，健康老龄化的重要性愈发凸显。脑白质高信号在老年人群中普遍存在，作为脑小血管病的重要影像学表现，它通常被视为大脑和心血管健康状况不佳的标志。已有研究表明，脑白质高信号与脑卒中之间存在显著关联。脑卒中是全球第二大死亡原因，其中最常见的是缺血性脑卒中，因其高致残率，严重影响患者的身心健康和生活质量。因此，深入理解脑白质高信号与缺血性脑卒中之间的关系显得尤为重要。本文将从脑白质高信号的病因机制、评估方法以及其与缺血性脑卒中发生风险和预后结局等方面进行综述，旨在为脑白质高信号的相关机制研究提供参考，并为深入探讨其与缺血性脑卒中的相关性提供依据。

Abstract: With the accelerating aging of the global population, the importance of healthy aging is becoming increasingly prominent. White matter hyperintensity is commonly observed in the elderly and is considered a significant imaging manifestation of cerebral small vessel disease. It is often regarded as a marker of poor brain and cardiovascular health. Existing studies have indicated a significant association between white matter hyperintensity and stroke. Stroke is the second leading cause of death worldwide, with ischemic stroke being the most common type. Due to its high rates of disability, ischemic stroke severely impacts patients’ physical and mental health, as well as their quality of life. Therefore, it is crucial to gain a deeper understanding of the relationship between white matter hyperintensity and ischemic stroke. This paper reviews the etiology and mechanisms of white matter hyperintensity, assessment methods, and its association with the risk of ischemic stroke and prognostic outcomes. The aim is to provide references for the mechanism of white matter hyperintensity and to substantiate further exploration of its correlation with ischemic stroke.