IL-22在肺结核合并糖尿病疾病的研究进展
Research Progress on IL-22 in Lung Tuberculosis Complicated with Diabetes
DOI: 10.12677/acm.2025.152348, PDF,   
作者: 黄 莎：吉首大学株洲临床学院，湖南 湘西；谭英征*：株洲市中心医院感染内科，湖南 株洲
关键词: IL-22；肺结核；结核合并糖尿病；细胞因子；免疫；IL-22； Pulmonary Tuberculosis； Tuberculosis Complicated by Diabetes； Cytokines； Immunity
摘要: 结核病的防治是全世界关注的公共卫生问题，糖尿病会增加结核病的发病风险，故结核合并糖尿病是一个值得关注的重点问题，近年来，细胞因子与抗结核感染的免疫机制密切相关，其中尤以IL-22与结核病的免疫联系紧密，IL-22与结核合并糖尿病的免疫联系的研究也是值得重点关注的，本文拟从IL-22的来源、结构、信号通路及IL-22在结核中，在结核合并糖尿病中的相关机制及作用的研究进展做一综述，从几个方面一同来探讨IL-22对于结核合并糖尿病疾病中的研究意义和价值，讨论IL-22能否成为这一合并病的评估疾病病情程度及预后的观测指标之一。
Abstract: The prevention and control of tuberculosis is a public health issue of global concern. Diabetes increases the risk of tuberculosis, making the co-occurrence of tuberculosis and diabetes a significant issue worthy of attention. In recent years, cytokines have been closely related to the immune mechanisms against tuberculosis infection, particularly IL-22, which has a strong immunological connection with tuberculosis. The research on the immune relationship between IL-22 and tuberculosis complicated by diabetes is also deserving of special focus. This paper aims to provide a review of the research progress on IL-22, including its sources, structure, signaling pathways, and its related mechanisms and roles in tuberculosis and in tuberculosis complicated by diabetes. Several aspects will be explored to discuss the significance and value of IL-22 in the context of tuberculosis and diabetes co-occurrence, as well as to evaluate whether IL-22 could serve as a potential observational indicator for assessing disease severity and prognosis in this comorbidity.
文章引用：黄莎, 谭英征. IL-22在肺结核合并糖尿病疾病的研究进展[J]. 临床医学进展, 2025, 15(2): 307-314. https://doi.org/10.12677/acm.2025.152348

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