中医药治疗多囊卵巢综合征伴胰岛素抵抗的可视化分析
Visualization Analysis of Traditional Chinese Medicine in the Treatment of Polycystic Ovary Syndrome with Insulin Resistance
DOI: 10.12677/acm.2025.152443, PDF,   
作者: 王文琪:黑龙江中医药大学研究生院,黑龙江 哈尔滨;张跃辉*:黑龙江中医药大学附属第一医院妇科一科,黑龙江 哈尔滨
关键词: 中医药多囊卵巢综合征胰岛素抵抗知识图谱可视化分析Traditional Chinese Medicine Polycystic Ovary Syndrome Insulin Resistant Mapping Knowledge Domains Visual Analysis
摘要: 目的:应用CiteSpace文献计量学方法对中医药治疗多囊卵巢综合征(Polycystic Ovarian Syndrome, PCOS)伴胰岛素抵抗(Insulin Resistant, IR)的研究进程与方向进行可视化分析。方法:检索中国知网数据库和Web of Science核心合集数据库2002~2022年中医药治疗PCOS-IR的相关文献,通过CiteSpace6.1R3软件绘制相应的知识图谱,对作者、机构、关键词共现、突现和聚类进行分析。结果:共纳入中文文献1065篇,英文文献436篇,侯丽辉、Stener victorin、Elisabet分别是中、英文发文量最多的作者,国内对该领域研究成果比国外多且起步早。主要研究内容有中医药治疗PCOS-IR的作用机制、中医特色疗法、中药药理分析、临床疗效观察等方面。结论:研究者们未来会聚焦于中医疗法对PCOS-IR作用机制的研究,注重内治法联合外治法或中西医结合治疗,并尽可能地开展动物试验探讨其起效的作用机理,以期对该疾病临床诊疗提供一定指导。
Abstract: Objective: To visually analyze the research process and direction of traditional Chinese medicine in the treatment of polycystic ovary syndrome with insulin resistance by CiteSpace bibliometrics. Methods: Search China knowledge net database and Web of Science core collection database related literature of traditional Chinese medicine treatment of PCOS-IR from 2002 to 2022, draw the corresponding knowledge graph through CiteSpace6.1R3 software, and analyze the co-occurrence, emergence and clustering of authors, institutions and keywords. Results: After screening, 1065 literatures were included in CNKI database and 436 literatures were included in Web of Science core database. The author co-occurrence analysis shows that the largest number of publications at home and abroad are Hou Lihui and Stener victorin, Elisabet. Domestic research results in this field are more than foreign countries and started earlier. The main research contents include the mechanism of action of Chinese medicine in the treatment of PCOS-IR, characteristic therapies of Chinese medicine, pharmacological analysis of Chinese medicine, and observation of clinical efficacy. Conclusion: In the future, researchers will focus on the role of TCM in the prevention, regression and healing of PCOS-IR, emphasizing the combination of internal and external therapies or the combination of Chinese and Western medicines, as well as conducting animal experiments as much as possible to explore the mechanism of its effect, with a view to providing some guidance for the clinical diagnosis and treatment of this disease.
文章引用:王文琪, 张跃辉. 中医药治疗多囊卵巢综合征伴胰岛素抵抗的可视化分析[J]. 临床医学进展, 2025, 15(2): 1049-1060. https://doi.org/10.12677/acm.2025.152443

参考文献

[1] Barbosa, G., de Sá, L.B.P.C., Rocha, D.R.T.W. and Arbex, A.K. (2016) Polycystic Ovary Syndrome (PCOS) and Fertility. Open Journal of Endocrine and Metabolic Diseases, 6, 58-65. [Google Scholar] [CrossRef
[2] Lebovitz, H. (2001) Insulin Resistance: Definition and Consequences. Experimental and Clinical Endocrinology & Diabetes, 109, S135-S148. [Google Scholar] [CrossRef] [PubMed]
[3] Azziz, R., Carmina, E., Chen, Z., Dunaif, A., Laven, J.S.E., Legro, R.S., et al. (2016) Polycystic Ovary Syndrome. Nature Reviews Disease Primers, 2, Article No. 16057. [Google Scholar] [CrossRef] [PubMed]
[4] Morley, L.C., Tang, T., Yasmin, E., Norman, R.J. and Balen, A.H. (2017) Insulin-Sensitising Drugs (Metformin, Rosiglitazone, Pioglitazone, D-Chiro-Inositol) for Women with Polycystic Ovary Syndrome, Oligo Amenorrhoea and Subfertility. Cochrane Database of Systematic Reviews, No. 11, CD003053. [Google Scholar] [CrossRef] [PubMed]
[5] 王晓冰, 侯丽辉, 吴效科. 痰浊与多囊卵巢综合征胰岛素抵抗的关系研究[J]. 中国中医基础医学杂志, 2008, 14(2): 122-124.
[6] 寇丽辉, 侯丽辉, 马建, 等. 多囊卵巢综合征(痰湿证)合并胰岛素抵抗患者的临床特征分析[J]. 中华中医药杂志, 2020, 35(4): 2113-2116.
[7] 常惠, 吴效科. 黄连素对PCOS治疗作用及相关机制研究进展[J]. 现代妇产科进展, 2017, 26(3): 235-237.
[8] 张多加, 吴效科. 多囊卵巢综合征患者中药临床应用策略[J]. 世界科学技术-中医药现代化, 2020, 22(6): 1836-1841.
[9] Wen, Q., Hu, M., Lai, M., Li, J., Hu, Z., Quan, K., et al. (2021) Effect of Acupuncture and Metformin on Insulin Sensitivity in Women with Polycystic Ovary Syndrome and Insulin Resistance: A Three-Armed Randomized Controlled Trial. Human Reproduction, 37, 542-552. [Google Scholar] [CrossRef] [PubMed]
[10] 逯克娜, 林寒梅. 肠道菌群与炎症因子参与多囊卵巢综合征的发病机制及中药干预的研究进展[J]. 中华中医药学刊, 2022, 40(3): 186-190.
[11] 陆迪, 于爽, 张阳. 多囊卵巢综合征伴胰岛素抵抗中西医机制进展[J]. 辽宁中医药大学学报, 2022, 24(2): 115-119.
[12] 张多加, 张明明, 王婷婷, 等. 小檗碱对多囊卵巢综合征大鼠卵巢局部胰岛素抵抗的调控作用[J]. 世界中医药, 2022, 17(17): 2429-2436.
[13] 陶柳, 庹安写, 刘茂艳. 桂枝茯苓丸联合黄连素对多囊卵巢综合征伴胰岛素抵抗患者的影响[J]. 中国实验方剂学杂志, 2013, 19(15): 320-323.
[14] Li, Y., Kuang, H., Shen, W., Ma, H., Zhang, Y., Stener-Victorin, E., et al. (2013) Letrozole, Berberine, or Their Combination for Anovulatory Infertility in Women with Polycystic Ovary Syndrome: Study Design of a Double-Blind Randomised Controlled Trial. BMJ Open, 3, e003934. [Google Scholar] [CrossRef] [PubMed]
[15] Lidaka, L., Bekere, L., Lazdane, G., Lazovska, M., Dzivite-Krisane, I. and Gailite, L. (2022) Role of Single Nucleotide Variants in the YAP1 Gene in Adolescents with Polycystic Ovary Syndrome. Biomedicines, 10, Article 1688. [Google Scholar] [CrossRef] [PubMed]
[16] 尹谦, 李美和, 梁婧翘, 等. 益肾祛浊方调节雌激素通路干预PCOS-IR大鼠脂代谢异常的研究[J]. 中华中医药杂志, 2023, 38(7): 3329-3333.
[17] 李梦元, 高征, 梁婧翘, 等. 益肾祛浊方对比二甲双胍治疗多囊卵巢综合征合并胰岛素抵抗的随机对照研究[J]. 中国全科医学, 2024, 27(27): 3411-3417, 3427.
[18] 顾颖, 许小凤, 何晓燕. 针刺改善多囊卵巢综合征糖脂代谢紊乱的疗效评价[J]. 时珍国医国药, 2019, 30(10): 2431-2433.
[19] 王紫燕, 杨卓欣, 黄杏贤, 等. 基于NLRP3信号通路探讨调任通督针法对多囊卵巢综合征大鼠激素失衡和胰岛素抵抗的影响[J]. 广州中医药大学学报, 2024, 41(12): 3243-3251.
[20] Greenwood, E.A., Pasch, L.A., Cedars, M.I., Legro, R.S., Eisenberg, E. and Huddleston, H.G. (2018) Insulin Resistance Is Associated with Depression Risk in Polycystic Ovary Syndrome. Fertility and Sterility, 110, 27-34. [Google Scholar] [CrossRef] [PubMed]