维持性血液透析患者认知功能障碍与血硒的研究进展
Research Progress of Cognitive Impairment and Serum Selenium in Maintenance Hemodialysis Patients
DOI: 10.12677/acm.2025.1561711, PDF,    科研立项经费支持
作者: 曹孟涛*, 张明霞：湖北民族大学医学部，湖北 恩施
关键词: 维持性血液透析；认知功能障碍；血硒；Maintenance Hemodialysis； Cognitive Impairment； Serum Selenium
摘要: 维持性血液透析(MHD)患者认知功能障碍(Cognitive Impairment, CI)的高发病率已成为影响其生活质量与预后的重要问题。近年来，血清硒(Se)等微量元素在MHD患者认知损伤中的作用机制及干预策略研究取得显著进展。本文系统综述了MHD患者CI的流行病学特征、血清硒与氧化应激–炎症轴的关联、其他危险因素的交互作用，以及硒补充治疗的临床证据，旨在为优化管理策略提供科学依据。
Abstract: The high incidence rate of cognitive impairment (CI) in maintenance hemodialysis (MHD) patients has become a critical issue affecting their quality of life and prognosis. Recent studies have made significant progress in elucidating the mechanisms and intervention strategies of trace elements, such as serum selenium (Se), in cognitive impairment among MHD patients. This article systematically reviews the epidemiological characteristics of CI in MHD patients, the association between serum selenium and the oxidative stress-inflammation axis, interactions with other risk factors, and clinical evidence for selenium supplementation therapy, aiming to provide a scientific basis for optimizing management strategies.
文章引用：曹孟涛, 张明霞. 维持性血液透析患者认知功能障碍与血硒的研究进展[J]. 临床医学进展, 2025, 15(6): 160-164. https://doi.org/10.12677/acm.2025.1561711

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