带状疱疹后神经痛发病机制：多因素交织的复杂谜题
Pathogenesis of Postherpetic Neuralgia: A Complex Puzzle of Interwoven Multifactors
DOI: 10.12677/jcpm.2025.43376, PDF,   
作者: 白文秀：延安大学医学院，陕西 延安；高彦东：延安大学第二附属医院榆林市第一医院疼痛科，陕西 榆林；边步荣：延安大学第二附属医院榆林市第一医院麻醉科，陕西 榆林
关键词: 带状疱疹后遗神经痛；神经炎症；胶质细胞；细胞因子；中枢敏化；疼痛环路；Postherpetic Neuralgia； Neuroinflammation； Glial Cells； Cytokines； Central Sensitization； Pain Circuit
摘要: 带状疱疹后神经痛(PHN)的发病机制复杂，其中神经炎症作为核心驱动因素，通过胶质细胞-神经元交互作用加剧疼痛的慢性化。本文聚焦于神经炎症在PHN中的关键作用，系统阐述病毒诱导的外周炎症如何通过细胞因子级联反应激活中枢胶质细胞，促进脊髓及脑区疼痛通路的敏化与重塑。结合最新研究探讨胶质细胞活化、促炎因子释放及靶向治疗的潜在价值，为PHN的精准干预提供理论依据。
Abstract: The pathogenesis of postherpetic neuralgia (PHN) is complex. Neuroinflammation, as a core driving factor, exacerbates the chronicity of pain through the interaction between glial cells and neurons. This article focuses on the key role of neuroinflammation in PHN, and systematically expounds how virus-induced peripheral inflammation activates central glial cells through the cytokine cascade reaction, promoting the sensitization and remodeling of pain pathways in the spinal cord and brain regions. Combined with the latest research, it explores the potential value of glial cell activation, the release of pro-inflammatory factors, and targeted therapy, providing a theoretical basis for the precise intervention of PHN.
文章引用：白文秀, 高彦东, 边步荣. 带状疱疹后神经痛发病机制：多因素交织的复杂谜题[J]. 临床个性化医学, 2025, 4(3): 512-519. https://doi.org/10.12677/jcpm.2025.43376

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