开阖六气针法改善老年性骨质疏松症患者静滴密固达后发热症的临床研究

Clinical Study on Kaihe Liuqi Acupuncture for Improving Fever Symptoms after Intravenous Infusion of Zoledronic Acid in Patients with Senile Osteoporosis

摘要: 目的：本研究通过观察应用开阖六气针法治疗老年性骨质疏松患者静滴密固达后发热症状的临床疗效及安全性，进一步推广开阖六气针法临床应用，以期寻求一种安全有效的改善老年性骨质疏松症患者静滴密固达后发热症状的方法。方法：本研究中最终共纳入110例受试者作为研究对象，其中开阖六气针法组37例，普通针法组37例，对照组36例，观察比较三组受试者的一般资料情况、疗效指标、依从性、经济效应、治疗前后C反应蛋白以及安全性的差异。结果：六气针法组、普通针法组、对照组三组的一般资料比较无差异，P > 0.05。治疗前C反应蛋白比较，P > 0.05，差异无统计学意义。治疗后C反应蛋白比较，P < 0.05，具有统计学意义。三组的腋温开始下降时间、腋温复常时间、腋温复常后反复时间比较，P < 0.05，差异具有统计学意义。三组的即时疗效、持续效果、总体疗效、依从性及安全性比较，P < 0.05，差异具有统计学意义。三组治疗后经济效应比较，P > 0.05，差异无统计学意义。结论：本研究通过临床研究发现，应用六气针法以及口服对乙酰氨基酚片及对患者静脉滴注密固达后的体温下降具有更好的效应，更能够较应用普通针刺方法能够缩短腋温开始下降时间及腋温复常时间。另外，也能够缩短腋温复常时间，使得静滴密固达后发热不良反应的持续时间更短，更好地达到改善静滴密固达后发热不良反应的目的。三组之间的经济效应指标无差异，而应用开阖六气针法及普通针刺治疗较口服对乙酰氨基酚片的依从性更好，安全等级更高。

Abstract: Objective: This study aims to observe the clinical efficacy and safety of Kaihe Liuqi acupuncture in treating fever symptoms after intravenous infusion of zoledronic acid (Zometa) in patients with senile osteoporosis, further promote the clinical application of Kaihe Liuqi acupuncture, and seek a safe and effective method to improve fever symptoms after intravenous infusion of zoledronic acid in such patients. Methods: A total of 110 subjects were finally included in this study, divided into three groups: the Kaihe Liuqi acupuncture group (37 cases), the conventional acupuncture group (37 cases), and the control group (36 cases). General data, efficacy indicators, compliance, economic effects, C-reactive protein (CRP) levels before and after treatment, and safety were observed and compared among the three groups. Results: There were no significant differences in general data among the three groups (P > 0.05). Before treatment, there was no significant difference in CRP levels among the three groups (P > 0.05). After treatment, CRP levels showed significant differences (P < 0.05). Significant differences were observed among the three groups in the time to start axillary temperature decline, time to axillary temperature normalization, and time to recurrence after normalization (P < 0.05). Significant differences were found in immediate efficacy, sustained effect, overall efficacy, compliance, and safety among the three groups (P < 0.05). There was no significant difference in economic effects among the three groups after treatment (P > 0.05). Conclusion: This clinical study found that Kaihe Liuqi acupuncture, combined with oral acetaminophen tablets, demonstrates a better effect in reducing body temperature after intravenous infusion of zoledronic acid compared to conventional acupuncture. It can shorten the time to start axillary temperature decline and the time to axillary temperature normalization, reduce the duration of fever adverse reactions after zoledronic acid infusion, and more effectively improve fever symptoms. There were no differences in economic indicators among the three groups, while Kaihe Liuqi acupuncture and conventional acupuncture showed better compliance and higher safety levels than oral acetaminophen tablets.