生物可降解高分子材料在长效注射剂中的研究进展及应用
Research Progress and Application of Biodegradable Polymer Materials in Long-Acting Injections
DOI: 10.12677/hjbm.2025.154078, PDF,   
作者: 朱承莉*:重庆医科大学药学院,重庆;福安药业集团重庆礼邦药物开发有限公司,重庆;张 涛:福安药业集团重庆礼邦药物开发有限公司,重庆;冯 涛#:重庆医科大学药学院,重庆
关键词: 生物可降解高分子材料长效注射剂特性应用Biodegradable Polymer Materials Long-Acting Injection Characteristic Apply
摘要: 当前,在国内外长效注射剂(Long-acting injection, LAI)的研究过程中,基于生物可降解高分子材料的LAI递送系统是近年来研究最多的。生物可降解高分子材料可分为天然产物与人工合成两大类。其中,人工合成生物可降解的高分子材料是通过化学合成的手段制备的聚合物材料,其物理化学性质可根据人们的需求进行调控,其主链中通常含有不稳定的化学键从而来实现生物可降解的功能。本综述总结了目前常见的几种用于长效注射给药系统的生物可降解高分子材料的应用现状,并对其各种性能以及优缺点进行分析。
Abstract: At present, in the research process of Long-acting injection (LAI) at home and abroad, LAI delivery system based on biodegradable polymer materials is the most studied in recent years. Biodegradable polymer materials can be divided into natural and synthetic materials. Among them, synthetic biodegradable polymer materials are polymer materials prepared by means of chemical synthesis, and their physical and chemical properties can be regulated according to people's needs, and their main chain usually contains unstable chemical bonds to achieve biodegradable functions. This review summarizes the current application status of several biodegradable polymer materials for long-acting injection drug delivery systems, and analyzes their various properties, advantages and disadvantages.
文章引用:朱承莉, 张涛, 冯涛. 生物可降解高分子材料在长效注射剂中的研究进展及应用[J]. 生物医学, 2025, 15(4): 715-724. https://doi.org/10.12677/hjbm.2025.154078

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