PGC-1α在中枢神经胶质细胞中的作用研究进展
Research Progress on the Role of PGC-1α in Central Nervous System Glial Cells
DOI: 10.12677/acm.2025.1582192, PDF,   
作者: 王姜琦：青岛大学医学部，山东 青岛；宋玉强*：青岛大学附属医院神经内科，山东 青岛
关键词: PGC-1α；神经胶质细胞；小胶质细胞；星形胶质细胞；少突胶质细胞；PGC-1α； Nervous System Glial Cells； Microglia； Astrocytes； Oligodendrocytes
摘要: 过氧化物酶体增殖物激活受体γ共激活因子-1α (PGC-1α)作为一种关键的转录共激活因子，在中枢神经系统神经胶质细胞中发挥着不可或缺的作用，和诸多神经疾病发生发展进程紧密相连。本文全面阐述了PGC-1α在小胶质细胞、星形胶质细胞、少突胶质细胞等中枢神经胶质细胞中的表达、功能、调控机制以及其与中枢神经系统疾病关联的研究进展，旨在为神经系统疾病新的治疗方向带来启发。
Abstract: The peroxisome proliferator-activated receptor gamma co-activator-1α (PGC-1α), as a crucial transcriptional co-activator, plays an indispensable role in the central nervous system glial cells and is closely associated with the occurrence and development of various neurological diseases. This article comprehensively reviews the expression, function, and regulatory mechanisms of PGC-1α in central nervous system glial cells such as microglia, astrocytes, and oligodendrocytes, as well as the research progress on its association with various central nervous system diseases. The aim is to provide insights into new treatment directions for neurological diseases.
文章引用：王姜琦, 宋玉强. PGC-1α在中枢神经胶质细胞中的作用研究进展[J]. 临床医学进展, 2025, 15(8): 13-18. https://doi.org/10.12677/acm.2025.1582192

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