补中益气汤治疗自身免疫性甲状腺炎的研究进展
Research Progress of Buzhong Yiqi Decoction in the Treatment of Autoimmune Thyroiditis
DOI: 10.12677/acm.2025.1582277, PDF,   
作者: 柴智强*：黑龙江中医药大学研究生院，黑龙江 哈尔滨；叶 婷#：黑龙江中医药大学附属第二医院内分泌科，黑龙江 哈尔滨
关键词: 补中益气汤；自身免疫性甲状腺炎；综述；研究进展；Buzhong Yiqi Decoction； Autoimmune Thyroiditis； Review； Research Progress
摘要: 自身免疫性甲状腺炎(Autoimmune Thyroiditis, AIT)是最常见的甲状腺疾病，是世界上碘充足地区甲状腺功能减退的主要原因。其原因被认为是遗传易感性和环境因素的结合，导致免疫耐受性丧失，从而导致甲状腺组织的自身免疫攻击和疾病的出现。补中益气汤(Buzhong Yiqi Decoction, BZYQD)是著名的中草药配方，具有“补气、升阳、健脾”的功效。研究表明，补中益气汤中的有效成分可以通过调控不同的信号通路，进而影响AIT疾病的发生发展。此文结合自身免疫性甲状腺炎的相关通路，以及补中益气汤的最新研究情况，对其治疗自身免疫性甲状腺炎的作用机制进行综述，以期为该方的临床应用和后续深入研究提供参考。
Abstract: Autoimmune Thyroiditis (AIT) is the most common thyroid disease and the main cause of hypothyroidism in iodine-abundant regions around the world. The cause is believed to be a combination of genetic susceptibility and environmental factors, resulting in loss of immune tolerance, which leads to autoimmune attack of thyroid tissue and the emergence of diseases. Buzhong Yiqi Decoction (BZYQD) is a famous Chinese herbal formula with the effects of “nourishing qi, raising yang and strengthening the spleen”. Studies have shown that the active ingredients in Buzhong Yiqi Decoction can affect the occurrence and development of AIT diseases by regulating different signaling pathways. Combining the relevant pathways of autoimmune thyroiditis and the latest research situation of Buzhong Yiqi Decoction, this paper reviews the mechanism of its treatment of autoimmune thyroiditis, in order to provide a reference for the clinical application and follow-up in-depth research of this prescription.
文章引用：柴智强, 叶婷. 补中益气汤治疗自身免疫性甲状腺炎的研究进展[J]. 临床医学进展, 2025, 15(8): 642-647. https://doi.org/10.12677/acm.2025.1582277

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