柚皮素对多囊卵巢综合征的作用机制研究进展
Progress in the Study of the Mechanisms of Naringenin in Polycystic Ovary Syndrome
摘要: 多囊卵巢综合征(polycystic ovary syndrome, PCOS)是一种常见的生殖内分泌疾病，临床以高雄激素血症、排卵障碍等为特征，发病率达8%~13%。由于PCOS的发病机制尚不明确，因此临床仍以对症激素治疗为主，而长期使用激素不仅会增加患心血管疾病等疾病的风险，还严重影响女性的心理健康。柚皮素(naringenin, 5,7,4’-trihydroxyflavanone)是一种天然黄酮类化合物，具有调节糖脂代谢、抗炎、抗氧化及抑制血管生成等药理活性。研究发现，柚皮素可以通过调节性激素水平、改善胰岛素抵抗、抗炎、降低氧化应激水平恢复排卵等途径改善PCOS，笔者通过对近年来国内外文献进行综述，以期为临床开发新兴药物提供思路及参考。
Abstract: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, characterized by hyperandrogenemia and ovulatory dysfunction, with an incidence rate of 8% to 13%. As the pathogenesis of PCOS is still unclear, clinical treatment mainly focuses on symptomatic hormone therapy. However, long-term use of hormones not only increases the risk of cardiovascular diseases but also severely affects women’s psychological health. Naringenin (5,7,4’-trihydroxyflavanone) is a natural flavonoid compound possessing pharmacological activities such as regulating glucose and lipid metabolism, anti-inflammation, anti-oxidation, and inhibiting angiogenesis. Studies have found that naringenin can improve PCOS by regulating sex hormone levels, improving insulin resistance, anti-inflammation, reducing oxidative stress levels, and restoring ovulation. This article reviews the domestic and international literature in recent years, with the expectation of providing ideas and references for the development of new drugs in clinical practice.
文章引用：赵彬, 沈文娟. 柚皮素对多囊卵巢综合征的作用机制研究进展[J]. 临床医学进展, 2025, 15(10): 994-999. https://doi.org/10.12677/acm.2025.15102847

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