基于网络药理学的桃仁–红花药对治疗深静脉血栓形成机制研究

The Mechanism of the Herb Pair Persicae Semen-Carthami Flos in the Treatment of Deep Vein Thrombosis Based on Network Pharmacology

摘要: 目的：运用网络药理学方法探讨桃仁–红花药对治疗深静脉血栓形成的作用机制。方法：通过TCMSP数据库筛选出桃仁–红花药对的有效成分并对其进行靶点预测；通过OMIM数据库、GeneCards数据库和TTD数据库收集深静脉血栓形成的靶点；运用Cytoscape3.8.0软件构建药物–成分–靶点–疾病网络图；ClueGO插件进行桃仁–红花药对治疗深静脉血栓形成调控生物过程和通路富集分析。结果：获得桃仁–红花药对44个有效成分，217个潜在靶点，深静脉血栓形成261个靶点，GO分析得到1935条功能条目，KEGG分析共得到128条信号通路。结论：桃仁–红花药对的有效成分可能通过参与部分炎性反应通路、AGE-RAGE信号通路等，发挥抗凝、抗炎、保护血管等功能，起到治疗深静脉血栓形成的作用。

Abstract: Objective: To investigate the mechanism of action of the herb pair Persicae Semen-Carthami Flos in the treatment of deep vein thrombosis using network pharmacology. Methods: Active components of the Persicae Semen-Carthami Flos herb pair were screened and their targets predicted via the TCMSP database. Targets related to deep vein thrombosis were collected from the OMIM, GeneCards, and TTD databases. A drug-component-target-disease network diagram was constructed using Cytoscape3.8.0 software. The ClueGO plugin was employed for enrichment analysis of the biological processes and pathways regulated by the Persicae Semen-Carthami Flos herb pair in the treatment of deep vein thrombosis. Results: A total of 44 active components and 217 potential targets of the Persicae Semen-Carthami Flos herb pair were identified, along with 261 targets associated with deep vein thrombosis. GO analysis yielded 1935 functional entries, and KEGG analysis revealed 128 signaling pathways. Conclusion: The active components of the Persicae Semen-Carthami Flos herb pair may exert anticoagulant, anti-inflammatory, and vascular protective effects by participating in certain inflammatory response pathways, the AGE-RAGE signaling pathway, and others, thereby playing a therapeutic role in deep vein thrombosis.