晚期乙状结肠癌伴肝肺转移多学科协作诊疗模式下获长期生存病例报告
Long-Term Survival Case Report of Advanced Sigmoid Carcinoma of Colon with Liver and Lung Metastases under Multidisciplinary Collaborative Diagnosis and Treatment Mode
DOI: 10.12677/acm.2025.15102874, PDF,    科研立项经费支持
作者: 欧阳明莲, 李佳聪, 刘骐源, 曾祥福, 赵书锋*:赣南医科大学第一附属医院胃肠外科,江西 赣州;刘欣欣:赣南医科大学第一临床医学院,江西 赣州;叶建明*:赣南医科大学第一附属医院肿瘤科,江西 赣州
关键词: 结直肠癌肝转移肺转移多学科团队转化治疗长期生存Colorectal Cancer Liver Metastasis Lung Metastasis Multidisciplinary Team Conversion Therapy Long-Term Survival
摘要: 本文报告1例初诊为IV期乙状结肠癌伴同时性肝、肺转移的患者,通过多学科团队(MDT)协作模式制定个体化诊疗策略,包括精准的转化治疗、序贯性局部根治性手术及转移灶消融/切除、系统治疗方案的动态调整与维持治疗,最终获得超过9年的长期无复发生存。本案例充分体现了MDT模式在晚期结直肠癌综合治疗中的核心价值,为类似患者提供了可借鉴的诊疗思路。
Abstract: This article reports a case of a patient initially diagnosed with stage IV sigmoid carcinoma of colon accompanied by synchronous liver and lung metastases. Through the multidisciplinary team MDT collaborative model, an individualized diagnosis and treatment strategy was formulated, including precise conversion therapy, sequential local radical surgery, ablation/resection of metastatic lesions, dynamic adjustment of systemic treatment regimens, and maintenance therapy. Ultimately, the patient achieved long-term recurrence-free survival exceeding 9 years. This case fully demonstrates the core value of the MDT model in the comprehensive treatment of advanced colorectal cancer, providing a reference for the diagnosis and treatment of similar patients.
文章引用:欧阳明莲, 李佳聪, 刘骐源, 刘欣欣, 曾祥福, 叶建明, 赵书锋. 晚期乙状结肠癌伴肝肺转移多学科协作诊疗模式下获长期生存病例报告[J]. 临床医学进展, 2025, 15(10): 1209-1214. https://doi.org/10.12677/acm.2025.15102874

参考文献

[1] Siegel, R.L., Wagle, N.S., Cercek, A., Smith, R.A. and Jemal, A. (2023) Colorectal Cancer Statistics, 2023. CA: A Cancer Journal for Clinicians, 73, 233-254. [Google Scholar] [CrossRef] [PubMed]
[2] Dekker, E., Tanis, P.J., Vleugels, J.L.A., Kasi, P.M. and Wallace, M.B. (2019) Colorectal Cancer. The Lancet, 394, 1467-1480. [Google Scholar] [CrossRef] [PubMed]
[3] Douillard, J., Oliner, K.S., Siena, S., Tabernero, J., Burkes, R., Barugel, M., et al. (2013) Panitumumab-FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer. New England Journal of Medicine, 369, 1023-1034. [Google Scholar] [CrossRef] [PubMed]
[4] Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., et al. (2004) Bevacizumab Plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer. New England Journal of Medicine, 350, 2335-2342. [Google Scholar] [CrossRef] [PubMed]
[5] 重庆市医学会肿瘤学分会化疗学组, 重庆大学附属肿瘤医院结直肠癌MDT专家组. 结直肠癌化疗合理用药原则专家共识[J/OL]. 中国医院用药评价与分析, 2023: 1-16. 2025-08-21.[CrossRef
[6] 李波, 何欣, 罗宏涛, 等. 探讨CK7CK20和TTF-1在判断转移性腺癌原发病灶中的应用价值[J]. 中国肿瘤临床, 2012, 39(10): 683-686.
[7] 王玉坤, 孙适然, 张津铖, 等. 调脾安肠方对裸鼠结肠癌肝转移灶miR-34a-5p、Notch1/NF-κB表达的影响[J]. 环球中医药, 2024, 17(3): 407-413.
[8] 李易津, 李俊. 肠癌肝转移外科治疗的国际进展[J]. 肝胆外科杂志, 2024, 32(3): 230-236.
[9] 张钧则. 结直肠癌肺转移的预后因素及原发灶手术联合多模式治疗的生存获益分析[D]: [硕士学位论文]. 广州: 南方医科大学, 2023.
[10] 陈威, 赵红, 王娜, 等. 医疗机构推广多学科诊疗案例分析[J]. 中华医院管理杂志, 2019, 35(4): 302-306.
[11] 樊嘉, 吕超. 复旦大学附属中山医院: 多学科协作为患者保驾护航[J]. 中国卫生, 2023(8): 28-29.
[12] 张小燕, 侯晓春. 参芪扶正注射液联合XELOX化疗对老年结直肠癌患者T淋巴细胞亚群, CEA, CA125和CA724及生存质量的影响[J]. 中国老年学杂志, 2021, 41(23): 5201-5203.
[13] 刘振方. 结肠癌根治切除术联合局部或全身化疗预防肝转移前瞻对照临床研究[Z]. 石家庄: 石家庄市中医院, 2023-08-03.
[14] Kopetz, S., Chang, G.J., Overman, M.J., Eng, C., Sargent, D.J., Larson, D.W., et al. (2009) Improved Survival in Metastatic Colorectal Cancer Is Associated with Adoption of Hepatic Resection and Improved Chemotherapy. Journal of Clinical Oncology, 27, 3677-3683. [Google Scholar] [CrossRef] [PubMed]
[15] Yaeger, R., Chatila, W.K., Lipsyc, M.D., Hechtman, J.F., Cercek, A., Sanchez-Vega, F., et al. (2018) Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. Cancer Cell, 33, 125-136.e3. [Google Scholar] [CrossRef] [PubMed]
[16] Pastorino, U., Buyse, M., Friedel, G., Ginsberg, R.J., Girard, P., Goldstraw, P., et al. (1997) Long-Term Results of Lung Metastasectomy: Prognostic Analyses Based on 5206 Cases. The Journal of Thoracic and Cardiovascular Surgery, 113, 37-49. [Google Scholar] [CrossRef] [PubMed]
[17] Lipsyc, M. and Yaeger, R. (2015) Impact of Somatic Mutations on Patterns of Metastasis in Colorectal Cancer. Journal of Gastrointestinal Oncology, 6, 645-649.