猪链球菌致脑膜炎并发双耳全聋1例报告
A Case Report of Meningitis Caused by Streptococcus suis Complicated with Total Deafness in Both Ears
DOI: 10.12677/acm.2025.15102875, PDF,    科研立项经费支持
作者: 李思忆, 施志强, 王 艺:云南中医药大学第一临床医学院,云南 昆明
关键词: 猪链球菌脑膜炎双耳全聋人工耳蜗Streptococcus suis Meningitis Total Deafness in Both Ears Cochlear Implant
摘要: 目的:本研究报道一例猪链球菌感染导致的化脓性脑膜炎合并双侧极重度混合性聋的临床病例,旨在为该疾病的诊断和治疗提供临床参考依据。方法:通过对该病例的系统分析,并结合文献复习,探讨其临床特征及干预治疗策略。结果:病例分析显示,该患者为中年男性,急性起病,主要表现为发热、头痛、头晕及快速进展的双侧听力下降,经病原学检测确诊为猪链球菌性脑膜炎。经过规范的抗感染治疗(包括敏感抗生素和糖皮质激素的应用),患者感染得到有效控制,但双侧仍遗留严重的永久性听力损失。结论:本案例提示,猪链球菌感染起病急骤,病情进展迅速,听力障碍并发症发生率高。对于此类患者,在感染控制后可尽早行听力康复评估,当传统治疗无效时,可考虑早期人工耳蜗植入等干预措施以改善预后。
Abstract: Objective: This study reports a clinical case of purulent meningitis caused by Streptococcus suis infection complicated with bilateral extremely severe mixed deafness, aiming to provide clinical reference for the diagnosis and treatment of this disease. Methods: Through systematic analysis of the case and literature review, the clinical characteristics and intervention treatment strategies were explored. Results: The case analysis showed that the patient was a middle-aged male with acute onset mainly presenting with fever, headache, dizziness and rapidly progressing bilateral hearing loss. The diagnosis of Streptococcus suis meningitis was confirmed by pathogen detection. After standardized anti-infection treatment (including the application of sensitive antibiotics and glucocorticoids), the infection was effectively controlled, but severe permanent bilateral hearing loss remained. Conclusion: This case suggests that Streptococcus suis infection has an acute onset, rapid disease progression, and a high incidence of hearing impairment complications. For such patients, hearing rehabilitation assessment should be conducted as early as possible after infection control. When traditional treatment is ineffective, early cochlear implantation and other intervention measures can be considered to improve prognosis.
文章引用:李思忆, 施志强, 王艺. 猪链球菌致脑膜炎并发双耳全聋1例报告[J]. 临床医学进展, 2025, 15(10): 1215-1221. https://doi.org/10.12677/acm.2025.15102875

参考文献

[1] 吕强, 吴建林, 袁珩, 等. 四川省人感染猪链球菌病流行病学调查分析[J]. 预防医学情报杂志, 2005(4): 379-383.
[2] Huong, V.T.L., Ha, N., Huy, N.T., Horby, P., Nghia, H.D.T., Thiem, V.D., et al. (2014) Epidemiology, Clinical Manifestations, and Outcomes of Streptococcus suis infection in Humans. Emerging Infectious Diseases, 20, 1105-1114. [Google Scholar] [CrossRef] [PubMed]
[3] 卫生部关于印发《人感染猪链球菌病诊疗方案》的通知[J]. 中华人民共和国卫生部公报, 2007(1): 3-12.
[4] Manzin, A., Palmieri, C., Serra, C., Saddi, B., Princivalli, M.S., Loi, G., et al. (2008) Streptococcus suis Meningitis without History of Animal Contact, Italy. Emerging Infectious Diseases, 14, 1946-1949. [Google Scholar] [CrossRef] [PubMed]
[5] Zhu, Y., Zhu, F., Bo, L., Fang, Y. and Shan, X. (2021) A Rare Case of Meningitis and Septicemia Caused by Streptococcus suis in a Woman without a History of Live Pig Contact or Eating Raw Pork. Brazilian Journal of Microbiology, 52, 2007-2012. [Google Scholar] [CrossRef] [PubMed]
[6] Brizuela, J., Korsten, K., van Rossen, T.M. and Schultsz, C. (2025) First Case of Streptococcus suis Bacteremia Caused by a Serotype 14 Strain without Pig or Pork Contact in the Netherlands: A Case Report. Diagnostic Microbiology and Infectious Disease, 111, Article ID: 116669. [Google Scholar] [CrossRef] [PubMed]
[7] Nhung, N.T., Yen, N.T.P., Cuong, N., Kiet, B.T., Hien, V.B., Campbell, J., et al. (2020) Carriage of the Zoonotic Organism Streptococcus suis in Chicken Flocks in Vietnam. Zoonoses and Public Health, 67, 843-848. [Google Scholar] [CrossRef] [PubMed]
[8] 杨维中, 余宏杰, 景怀琦, 等. 四川省一起伴中毒性休克综合征的人感染猪链球菌2型暴发[J]. 中华流行病学杂志, 2006(3): 185-191.
[9] 萧松建, 周奕. 2018-2023年广东省珠海市人感染猪链球菌病流行病学和临床特征分析[J]. 现代疾病预防控制, 2024, 35(12): 927-930.
[10] 何孔旺, 陆承平. 猪链球菌2型的致病特性与毒力因子[J]. 中国兽医科技, 2000(9): 17-20.
[11] Feng, Y., Zhang, H., Ma, Y. and Gao, G.F. (2010) Uncovering Newly Emerging Variants of Streptococcus suis, an Important Zoonotic Agent. Trends in Microbiology, 18, 124-131. [Google Scholar] [CrossRef] [PubMed]
[12] Zhu, J., Wang, J., Kang, W., Zhang, X., Kerdsin, A., Yao, H., et al. (2024) Streptococcus suis Serotype 4: A Population with the Potential Pathogenicity in Humans and Pigs. Emerging Microbes & Infections, 13, Article ID: 2352435. [Google Scholar] [CrossRef] [PubMed]
[13] Wei, Z., Li, R., Zhang, A., He, H., Hua, Y., Xia, J., et al. (2009) Characterization of Streptococcus suis Isolates from the Diseased Pigs in China between 2003 and 2007. Veterinary Microbiology, 137, 196-201. [Google Scholar] [CrossRef] [PubMed]
[14] 李建华, 薛花, 熊衍峰, 等. 2019-2021年赣州市人感染猪链球菌病流行病学及病原学特征[J]. 赣南医学院学报, 2022, 42(7): 717-719.
[15] 王楷宬. 猪链球菌病的流行病学[J]. 中国动物检疫, 2013, 30(10): 29-33.
[16] Benea, S.N., Moroti, R., Deaconu, T., Ciont, C., Benea, M.A. and Savulescu Fiedler, I. (2025) Streptococcus suis: A Possible Emerging Zoonotic Pathogen in Romania. Microorganisms, 13, Article 335. [Google Scholar] [CrossRef] [PubMed]
[17] Panpaeng, C., Kamolvit, W., Karaketklang, K. and Jitmuang, A. (2025) Clinical Characteristics and Trends in the Antimicrobial Susceptibility Profile of Streptococcus suis Infections in a Large Tertiary Hospital, Thailand, 2007-2023. PLOS Neglected Tropical Diseases, 19, e0013110. [Google Scholar] [CrossRef] [PubMed]
[18] Kay, R. (1991) The Site of the Lesion Causing Hearing Loss in Bacterial Meningitis: A Study of Experimental Streptococcal Meningitis in Guinea‐Pigs. Neuropathology and Applied Neurobiology, 17, 485-493. [Google Scholar] [CrossRef] [PubMed]
[19] Tenenbaum, T., Matalon, D., Adam, R., Seibt, A., Wewer, C., Schwerk, C., et al. (2008) Dexamethasone Prevents Alteration of Tight Junction-Associated Proteins and Barrier Function in Porcine Choroid Plexus Epithelial Cells after Infection with Streptococcus suis in Vitro. Brain Research, 1229, 1-17. [Google Scholar] [CrossRef] [PubMed]
[20] 张兆刚. 人工耳蜗及相关技术的研究进展[J]. 医疗装备, 2022, 35(11): 187-189.
[21] Chen, Z., Gao, M., Huang, X., Li, X., Huang, X., OU, Y., et al. (2024) Cochlear Implantation in Patients with Streptococcus suis Meningitis: Clinical Characteristics and Postoperative Evaluation. Acta Oto-Laryngologica, 144, 136-141. [Google Scholar] [CrossRef] [PubMed]
[22] 孔雨, 张婧, 王琳. 猪链球菌脑膜炎患者行人工耳蜗植入术一例[J]. 华西医学, 2022, 37(6): 959-960.