中药配合针灸治疗中风作用机制的研究进展

Advances in Research on the Mechanism of Action of Traditional Chinese Medicine Combined with Acupuncture in the Treatment of Stroke

摘要: 中风因其发病频率高、致残致死概率大的特点，严重危害着人们的健康。中药与针灸合用作为常规治疗方法，在中风治疗中发挥着不可替代的作用。本文从改善中风发病后的主要病理生理改变出发，说明中药与针灸发挥治疗中风协同作用的机制：中药抑制神经炎症和氧化应激、针灸疏通经络可抑制NF-κB/Nrf2通路从而发挥协同作用；活血化瘀中药和针灸疏通经络可改善脑内血循环；中药增强神经可塑性、针灸促进神经发生可通过调节神经递质的水平、增加神经营养因子的表达和神经干细胞增殖发挥协同作用。通过整理近年来的研究热点探讨了当前不足与未来发展趋势，为改善中风病治疗提供了帮助与指导。

Abstract: Stroke is marked by a high occurrence, a significant rate of disability, and a high death rate, posing a serious threat to human health. Traditional Chinese medicine (TCM) combined with acupuncture, as a traditional therapy, has shown unique advantages in stroke treatment. This article, starting from improving the main pathophysiological changes after stroke onset, elucidates the mechanism by which traditional Chinese medicine (TCM) and acupuncture exert synergistic effects in stroke treatment: TCM inhibits neuroinflammation and oxidative stress, while acupuncture unblocks meridians and inhibits the NF-κB/Nrf2 pathway, thus exerting a synergistic effect; TCM that promotes blood circulation and removes blood stasis, along with acupuncture that unblocks meridians, improves cerebral blood circulation; TCM enhances neural plasticity, and acupuncture promotes neurogenesis by regulating neurotransmitter levels, increasing the expression of neurotrophic factors, and promoting neural stem cell proliferation, thus exerting a synergistic effect. By summarizing recent research hotspots, the article discusses current shortcomings and future development trends, providing assistance and guidance for improving stroke treatment.