慢性阻塞性肺疾病急性加重期血液生物标志物的研究进展
Research Progress on Blood Biomarkers in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
DOI: 10.12677/jcpm.2026.51011, PDF,   
作者: 孙晶雨：济宁医学院临床医学院(附属医院)，山东 济宁；韩丽萍*：济宁市第一人民医院呼吸与危重症医学科，山东 济宁
关键词: 慢性阻塞性肺疾病；血液标记物；病情严重程度；预后；Chronic Obstructive Pulmonary Disease； Blood Biomarkers； Disease Severity； Prognosis
摘要: 慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease, COPD)简称慢阻肺，是一种进行性疾病，其主要特征是持续的气流受限、气道炎症以及全身效应或合并症。据统计，全世界约有5.45亿人患有COPD，是全球发病率和死亡率的第三大原因。慢性阻塞性肺疾病急性加重(Acute Exacerbation of Chronic Obstructive Pulmonary Disease, AECOPD)不仅并带来沉重的医疗保健费用负担，还会加速患者肺功能的丧失，显著增加其住院和死亡的风险。慢性阻塞性肺疾病发病机制复杂，近年来，有研究发现不同发病机制中血液生物学标志物在评估COPD严重程度及预后方面的存在潜在作用，因其客观、易获取的特性，在评估病情严重程度和预测预后方面展现出重要价值，本文将从血液生物学标志物对AECOPD严重程度的评估及预后影响进行综述。
Abstract: Chronic Obstructive Pulmonary Disease (COPD), often referred to as chronic obstructive lung disease, is a progressive condition characterized primarily by persistent airflow limitation, airway inflammation, and systemic effects or comorbidities. According to statistics, approximately 545 million people worldwide suffer from COPD, making it the third leading cause of morbidity and mortality globally. Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) not only imposes a heavy burden on healthcare costs but also accelerates the loss of patients’ lung function, significantly increasing their risk of hospitalization and death. The pathogenesis of COPD is complex. In recent years, studies have revealed the potential role of blood biomarkers in evaluating the severity and prognosis of COPD across different pathogenic mechanisms. Due to their objective and easily accessible nature, these biomarkers demonstrate significant value in assessing disease severity and predicting outcomes. This review will summarize the impact of blood biomarkers on the evaluation of AECOPD severity and prognosis.
文章引用：孙晶雨, 韩丽萍. 慢性阻塞性肺疾病急性加重期血液生物标志物的研究进展[J]. 临床个性化医学, 2026, 5(1): 67-73. https://doi.org/10.12677/jcpm.2026.51011

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