线粒体稳态失衡在血管内皮损伤中的研究进展
Advances in the Study of Mitochondrial Homeostasis Imbalance in Vascular Endothelial Injury
DOI: 10.12677/acm.2026.1631193, PDF,    科研立项经费支持
作者: 刘铠瑞, 赵璠瑜, 毕文杰, 石秀娟*, 韩利文*：山东第一医科大学(山东省医学科学院)药学院(药物研究所)，山东 济南；任 进：山东中医药大学药物研究院，山东，济南
关键词: 血管内皮；线粒体稳态；能量代谢；氧化应激；自噬；Vascular Endothelium； Mitochondrial Homeostasis； Energy Metabolism； Oxidative Stress； Autophagy
摘要: 血管内皮损伤与动脉粥样硬化、高血压、糖尿病、肺动脉高压等重大心血管疾病密切相关。线粒体作为细胞内能量供应的单元，其结构和功能稳态系统也广泛参与血管内皮的氧化应激、自噬等过程。本文立足于血管内皮类疾病的生理病理机制，重点探讨线粒体功能稳态介导的血管内皮损伤发生发展过程中的作用，以期为该类疾病的防治提供新的思路。
Abstract: Endothelial injury is closely linked to major cardiovascular diseases, including atherosclerosis, hypertension, diabetes mellitus, and pulmonary arterial hypertension. Mitochondria, as the energy-supplying units of the cell, have homeostatic systems that broadly participate in endothelial oxidative stress, autophagy, and related processes. This article, grounded in the physiological and pathological mechanisms of endothelial-related diseases, focuses on exploring the role of mitochondrial functional homeostasis in the onset and progression of endothelial injury, with the aim of providing new ideas for the prevention and treatment of these diseases.
文章引用：刘铠瑞, 赵璠瑜, 毕文杰, 任进, 石秀娟, 韩利文. 线粒体稳态失衡在血管内皮损伤中的研究进展[J]. 临床医学进展, 2026, 16(3): 3843-3849. https://doi.org/10.12677/acm.2026.1631193

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