2型糖尿病合并中枢性尿崩症1例
A Case Report of Type 2 Diabetes Mellitus Complicated with Central Diabetes Insipidus
DOI: 10.12677/jcpm.2026.52106, PDF,    科研立项经费支持
作者: 陈小婷：遂宁市第一人民医院内分泌科，四川 遂宁
关键词: 糖尿病；尿崩症；多尿；抗利尿激素；Diabetes； Diabetes Insipidus； Polyuria； Antidiuretic Hormone
摘要: 多饮、口干、多尿作为内分泌病人常见的主诉症状，最常见于因高血糖导致渗透性利尿的糖尿病。而尿崩症患者由于抗利尿激素(ADH)分泌不足或肾脏对ADH感应缺陷也可出现多尿等症状。临床上，糖尿病合并尿崩症病例报道较少，二者症状类似，易导致漏诊或误诊，需引起重视。本文通过1例2型糖尿病合并中枢性尿崩症(CDI)的临床病例学习及复习相关知识，旨在提升临床医生对这类罕见共病的认知及对此类病例的管理水平。
Abstract: Polydipsia, dry mouth, and polyuria as common presenting complaints in endocrine patients. They are most frequently seen in diabetes caused by osmotic diuresis due to high blood sugar. In patients with diabetes insipidus, symptoms such as polyuria can also occur due to deficient secretion of antidiuretic hormone (ADH) or a defect in the kidney’s response to ADH. Clinically, concurrent cases of diabetes mellitus and diabetes insipidus are rarely reported. Due to the similarity in their symptoms, such cases are prone to missed diagnosis or misdiagnosis, which warrants increased clinical attention. This article aims to enhance clinicians’ understanding of this rare comorbidity and improve their management of such cases by studying a clinical case of type 2 diabetes mellitus complicated by central diabetes insipidus (CDI) and reviewing the relevant literature.
文章引用：陈小婷. 2型糖尿病合并中枢性尿崩症1例[J]. 临床个性化医学, 2026, 5(2): 103-106. https://doi.org/10.12677/jcpm.2026.52106

参考文献

[1] Wolfram, D.J. (1938) Diabetes Mellitus and Simple Optic Atrophy among Siblings: Report of Four Cases. Mayo Clinic Proceedings, 13, 715-718. [Google Scholar] [CrossRef] 
[2] Rigoli, L., Caruso, V., Salzano, G. and Lombardo, F. (2022) Wolfram Syndrome 1: From Genetics to Therapy. International Journal of Environmental Research and Public Health, 19, Article 3225. [Google Scholar] [CrossRef] [PubMed]
[3] Caruso, V., Raia, A. and Rigoli, L. (2024) Wolfram Syndrome 1: A Neuropsychiatric Perspective on a Rare Disease. Genes, 15, Article 984. [Google Scholar] [CrossRef] [PubMed]
[4] Frasca, F., Piticchio, T., Le Moli, R., Malaguarnera, R., Campennì, A., Cannavò, S., et al. (2021) Recent Insights into the Pathogenesis of Autoimmune Hypophysitis. Expert Review of Clinical Immunology, 17, 1175-1185. [Google Scholar] [CrossRef] [PubMed]
[5] Sahoo, D.P., Rout, B.R. and War, G. (2025) Autoimmune Hypophysitis: A Cause of Central Diabetes Insipidus. Cureus, 17, e80369. [Google Scholar] [CrossRef] [PubMed]
[6] Tomkins, M., Lawless, S., Martin-Grace, J., Sherlock, M. and Thompson, C.J. (2022) Diagnosis and Management of Central Diabetes Insipidus in Adults. The Journal of Clinical Endocrinology & Metabolism, 107, 2701-2715. [Google Scholar] [CrossRef] [PubMed]
[7] Lu, Y., Wang, W., Liu, J., Xie, M., Liu, Q. and Li, S. (2023) Vascular Complications of Diabetes: A Narrative Review. Medicine, 102, e35285. [Google Scholar] [CrossRef] [PubMed]
[8] Mazumdar, D. and Singh, S. (2022) Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes. Indian Journal of Clinical Biochemistry, 39, 3-17. [Google Scholar] [CrossRef] [PubMed]
[9] Xu, Y., Lu, J., Li, M., Wang, T., Wang, K., Cao, Q., et al. (2024) Diabetes in China Part 1: Epidemiology and Risk Factors. The Lancet Public Health, 9, e1089-e1097. [Google Scholar] [CrossRef] [PubMed]
[10] Palumbo, C,. Nicolaci, N., La Manna, A.A., et al. (2018) Association between Central Diabetes Insipidus and Type 2 Diabetes Mellitus. Medicina, 78, 127-130.
[11] Ohara, N., Takada, T., Seki, Y., Akiyama, K. and Yoneoka, Y. (2022) A 75-Year-Old Woman with a 5-Year History of Controlled Type 2 Diabetes Mellitus Presenting with Polydipsia and Polyuria and a Diagnosis of Central Diabetes Insipidus. American Journal of Case Reports, 24, e938482. [Google Scholar] [CrossRef] [PubMed]