外泌体治疗皮肤光老化的机制与研究进展
Mechanisms and Research Progress of Exosomes in the Treatment of Skin Photoaging
DOI: 10.12677/md.2026.162028, PDF,   
作者: 和卓怡：昆明医科大学药学院，云南 昆明
关键词: 紫外线；皮肤光老化；外泌体；Ultraviolet Radiation； Skin Photoaging； Exosomes
摘要: 皮肤是人体抵御外界刺激的首要生理屏障，易受各类环境因素的影响而发生老化，其中紫外线辐射是诱发皮肤光老化的关键核心因素。皮肤光老化是紫外线致皮肤慢性退行性损伤，较自然老化更显著且累及更深，其核心发病机制包括氧化应激失衡、慢性炎症反应持续激活、细胞衰老进程加速以及细胞外基质降解异常，该病变不仅损害皮肤健康与外观形态，还可能显著增加皮肤癌的发病风险。外泌体作为细胞分泌的纳米级膜性囊泡，可携带蛋白质、核酸、脂质等多种生物活性成分，参与细胞间信号通讯并精准调控靶细胞功能。近年来外泌体已成为皮肤光老化治疗与干预领域的研究热点。本文结合近年来国内外相关研究进展，阐述皮肤光老化发病机制、外泌体生物学特性及其逆转皮肤光老化的分子机制，总结外泌体相关基础与临床研究进展，探讨其挑战与前景，为外泌体在皮肤光老化治疗中的进一步应用提供理论与实践参考。
Abstract: The skin serves as the primary physiological barrier of the human body against external stimuli and is susceptible to aging under the influence of various environmental factors, among which ultraviolet (UV) radiation is the key factor inducing skin photoaging. Skin photoaging refers to chronic degenerative skin damage caused by UV radiation, which is more prominent and involves deeper skin layers compared with natural aging. Its core pathogenesis includes oxidative stress imbalance, persistent activation of chronic inflammatory responses, accelerated cellular senescence, and abnormal degradation of the extracellular matrix. This pathological change not only impairs skin health and morphological appearance but also may significantly increase the risk of skin cancer. As nanoscale membranous vesicles secreted by cells, exosomes can carry a variety of bioactive components such as proteins, nucleic acids and lipids, participate in intercellular signal communication and precisely regulate the functions of target cells. In recent years, exosomes have become a research hotspot in the field of treatment and intervention for skin photoaging. Based on the relevant research progress at home and abroad in recent years, this paper elaborates on the pathogenesis of skin photoaging, the biological characteristics of exosomes and their molecular mechanisms in reversing skin photoaging, summarizes the progress of basic and clinical research related to exosomes, and discusses the challenges and prospects of exosome application, aiming to provide theoretical and practical references for the further application of exosomes in the treatment of skin photoaging.
文章引用：和卓怡. 外泌体治疗皮肤光老化的机制与研究进展[J]. 医学诊断, 2026, 16(2): 206-213. https://doi.org/10.12677/md.2026.162028

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