中药配方颗粒猫爪草提取液喷雾干燥工艺的研究

Research on Spray Drying Technology of Radix Ranunculi Ternati Formula Granules Extract Solution

摘要: 目的：研究不同辅料对解决中药配方颗粒猫爪草提取液喷雾干燥粘壁的效果。方法：采用L₉(3⁴)正交设计试验方法，以收粉率、含水量为考察指标，考察倍他环糊精、氧化钙、进风温度对猫爪草喷雾干燥的影响，优化喷雾干燥技术。结果：氧化钙添加量对喷雾干粉得率的影响具有显著性(P < 0.025)，进风温度对喷雾干粉含水量具有显著性(P < 0.05)。结论：优选喷雾干燥工艺为：14.8%可溶性淀粉、12%倍他环糊精、0.2%氧化钙、进风温度185℃。该工艺合理、可行，为工业化生产提供了实验性基础依据。

Abstract: Objective: To study the effect of different excipients on wall sticking by spray drying of radix ra-nunculi ternati formula granules extract solution. Method: Using the L₉(3⁴) orthogonal design method, powder collecting ratio and moisture content as the indicators, to investigate the influ-ence of β-cyclodextrin, calcium oxide and inlet air temperature on radix ranunculi ternati spray drying, optimize the spray drying technology. Results: The amount of calcium oxide has a signifi-cant effect on powder collecting ratio (P < 0.025), and the inlet air temperature has a significant effect on moisture content (P < 0.05). Conclusions: The best spray drying technology is 14.8% soluble starch, 12% β-cyclodextrin, 0.2% calcium oxide and inlet air temperature is 185˚C. This technology is reasonable and feasible, which can offer the experimental basis for industrialized production.