食管癌中MARCH2和DLG1的表达及其临床意义

Expression of MARCH2 and DLG1 in Esophagus Cancer and Their Clinical Significance

摘要: 目的：检测食管癌组织中膜相关环指蛋白2 (MARCH2)和肿瘤抑制蛋白(DLG1)的蛋白表达水平并分析其与临床病理参数的关系及两者的相关性。方法：用免疫组织化学方法检测50例食管癌及20例正常食管组织中MARCH2和DLG1的蛋白表达水平。结果：MARCH2和DLG1在50例食管癌组织中的阳性表达率分别为84%和18%，而MARCH2和DLG1在非肿瘤肠组织中的阳性表达率分别为25%和85%。MARCH2的阳性表达与更大肿瘤直径、不良分化、深度浸润、淋巴结转移和更高的TNM分期密切相关。DLG1表达的缺失与不良分化、深度浸润、淋巴结转移和更高的TNM分期密切相关。而且，MARCH2和DLG1的表达呈显著负相关。结论：MARCH2的高表达和DLG1表达的缺失可能促进食管癌的发生发展，并且与低分化和预后不良有关。MARCH2拮抗DLG1以促进食管癌的侵袭和转移。

Abstract: Aims: This study aimed to investigate whether the expressions of MARCH2 and DLG1 in esophagus carcinomas were associated with clinicopathological parameters. Methods: The expressions of MARCH2 and DLG1 were examined in 50 cases of esophagus carcinomas and 20 normal esophagus tissues using immunohistochemical staining. Results: The positive rates of MARCH2 and DLG1 ex-pressions in 50 cases of esophagus carcinoma were 84% and 18% respectively, whereas the posi-tive expression rates of MARCH2 and DLG1 in non-tumor intestinal tissues were 25% and 85% respectively. The positive expressions of MARCH2 were closely related to larger tumor, poor dif-ferentiation, deeper invasion, lymphnode metastasis and advanced TNM stage. In addition, loss of expression of DLG1 was significantly associated with poor differentiation, deeper invasion, lymphnode metastasis and advanced TNM stage. Furthermore, there were significant negative correlations between MARCH2 and DLG1 expression. Conclusions: The overexpression of MARCH2 and loss of expression of DLG1 were possibly involved in the development of esophagus carcinomas, and had correlations with low differentiation degree and bad prognosis. MARCH2 antagonized DLG1 to promote invasion and metastasis of esophagus cancer.