自身免疫性疾病相关的指标
Indicators Related to Autoimmune Diseases
DOI: 10.12677/MD.2019.92011, PDF,   
作者: 武凯丽*：内蒙古医科大学，内蒙古 呼和浩特
关键词: 单体CRP；MIF；S1P；Monomer CRP； MIF； S1P
摘要: 自身免疫性疾病由于抗原抗体复合物广泛沉积于血管壁等原因导致全身多器官损害，称系统性自身免疫病。习惯上又称之为胶原病或结缔组织病，这是由于免疫损伤导致血管壁及间质的纤维素样坏死性炎症及随后产生多器官的胶原纤维增生所致。CRP的单体在病变早期具有促炎效果，巨噬细胞移动抑制因子(MIF)在炎症过程中使炎症反应加剧，自身免疫性疾病中1磷酸鞘氨醇(S1P)的水平增加；因此我们可以推测单体CRP、MIF是否与S1P具有相关关系。
Abstract: Autoimmune diseases are called systemic autoimmune diseases because of the extensive deposi-tion of antigen-antibody complexes in the vascular wall and other reasons leading to systemic multiple organ damage. It is also known as collagen disease or connective tissue disease, which is caused by cellulose-like necrotizing inflammation of vascular wall and interstitium and subsequent proliferation of collagen fibers in multiple organs caused by immune injury. CRP monomer CRP has pro-inflammatory effect in the early stage of lesion, macrophage migration inhibitory factor (MIF) aggravates inflammation in the process of inflammation, and sphingosine 1 phosphate (S1P) level increases in autoimmune diseases; therefore, we can speculate whether CRP and MIF monomer are related to S1P.
文章引用：武凯丽. 自身免疫性疾病相关的指标[J]. 医学诊断, 2019, 9(2): 57-60. https://doi.org/10.12677/MD.2019.92011

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