FOXF2基因在肿瘤中的研究进展
Research Progress on FOXF2 Gene in Tumors
DOI: 10.12677/ACM.2021.112109, PDF,   
作者: 陈 勍:复旦大学附属中山医院骨科,上海;曹炎焱:复旦大学附属中山医院核医学科,上海
关键词: FOXF2转录因子转移肿瘤FOXF2 Transcription Factor Metastasis Tumor
摘要: 叉头盒蛋白F2 (FOXF2)是叉头/有翼螺旋家族的转录因子,参与正常的胚胎发育并调节多器官的发育和功能。最近的研究揭示了FOXF2在肿瘤中的发展和转移中起着抑制肿瘤增殖、迁移和侵袭的作用,但对其确切的潜在作用机制知之甚少。本文对FOXF2在肿瘤发生和发展中的功能和调控机制进行综述。
Abstract: Forkhead box protein F2 (FOXF2), a transcription factor of the forkhead/winged-helix family, is required for mesenchymal lineage specification and organ development during normal embryogenesis. Recent studies have revealed that FOXF2 plays a novel role in the development and metastasis of tumors, but very little is known about its exact potential mechanisms. This review summarizes the function and regulatory mechanisms of FOXF2 in tumorigenesis and progression.
文章引用:陈勍, 曹炎焱. FOXF2基因在肿瘤中的研究进展[J]. 临床医学进展, 2021, 11(2): 763-772. https://doi.org/10.12677/ACM.2021.112109

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