细胞自噬在雷公藤肝毒性中的研究进展
Research Progress of Hepatotoxicity Induced by Tripterygium wilfordii through Autophagy
DOI: 10.12677/PI.2021.106041, PDF,    国家自然科学基金支持
作者: 周 捷, 周学平*：南京中医药大学，江苏 南京
关键词: 自噬；雷公藤；肝毒性；Autophagy； Tripterygium wilfordii； Hepatotoxicity
摘要: 雷公藤是治疗风湿免疫病的常用药，疗效显著，但其毒副作用明显，尤以肝毒性多见。因此雷公藤肝毒性的相关研究对临床安全用药意义重大，已成为目前研究的热点与难点。细胞自噬是研究雷公藤肝毒性的新方向，备受相关领域学者的关注。本文通过文献查阅，从自噬的发生与调控机制、雷公藤肝毒性特点及物质基础、自噬与雷公藤肝毒性的关系等方面进行总结与归纳，旨在明确目前细胞自噬在雷公藤肝毒性研究中的现状和不足，为雷公藤肝毒性研究提供新的思路，并为临床合理用药提供参考。
Abstract: Tripterygium wilfordii (TW) has been widely used in the treatment of rheumatic immune diseases with curative effect. However, it has severe toxicity and adverse reactions, especially the hepatotoxicity. Therefore, the related research on the hepatotoxicity of TW is of great significance to clinical safe drug use, and has become the focal and difficult point in the current research. Autophagy is a new direction in the research of the hepatotoxicity of TW and has attracted the attention of scholars in related fields. Through literature review, this paper summarized the occurrence and regulation mechanism of autophagy, the characteristics and material basis of hepatotoxicity of TW, and the relationship between autophagy and the hepatotoxicity of TW. This paper clarified the current situation and deficiencies of autophagy in the research of hepatotoxicity of TW, so as to propose new research strategies and provide ideas for clinical rational drug use of TW.
文章引用：周捷, 周学平. 细胞自噬在雷公藤肝毒性中的研究进展[J]. 药物资讯, 2021, 10(6): 333-338. https://doi.org/10.12677/PI.2021.106041

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