带蒂组织瓣对比颞肌筋膜用于鼻中隔穿孔修补术的Meta分析

Meta Analysis of Nasal Septum Perforation with Pedicled Flaps Compared with Temporalis Fascia

摘要: 目的：系统评价使用带蒂组织瓣对比使用颞肌筋膜修补鼻中隔穿孔的疗效与安全性。方法：使用计算机检索中国学术期刊全文数据库(CNKI)、万方数据库、中国生物医学文献光盘数据库(CBM)、维普信息资源系统、中国科学引文数据库(CSCD)、Pubmed、EMbase、Cochrane Library数据库中有关带蒂组织瓣或颞肌筋膜修补鼻中隔穿孔临床试验的相关文献，检索时间从2002年1月至2022年2月，采用Review manager 5.4软件对符合条件的文献进行荟萃分析。结果：共纳入6个随机对照实验，合计274例患者。Meta分析结果显示：在鼻中隔穿孔修补术中，使用带蒂组织瓣相比颞肌筋膜，具有更少的复发率和更少的并发症，两者之间的差异有统计学意义[复发率OR = 0.14，95%CI (0.04, 0.47)，P = 0.002；并发症OR = 0.25，95%CI (0.09, 0.66)，P = 0.005]。结论：使用带蒂组织瓣在鼻中隔穿孔修补术中较使用颞肌筋膜效果明确，并发症少，临床治疗时可优先使用。

Abstract: Objective: Systematic evaluation of the efficacy and safety of pedicled flaps compared with tem-poralis fascia in repairing nasal septum perforation. Methods: The randomized controlled trials about Chinese academic Journal full-text Database (CNKI), Wanfang Database, Chinese Biomedical Literature CD-ROM Database (CBM), VIP Information Resource system, China Science Citation Data-base (CSCD), Pubmed, EMbase, Cochrane Library Database were searched for relevant literatures about clinical trials of repairing nasal septum perforation with pedicled flaps or temporalis fascia from January 2002 to February 2022. The meta-analyses were conducted by using Revman 5.4 software. Results: A total of 6 RTCs were included, and 274 patients were involved. In the repair of nasal septum perforation, compared with temporalis fascia, the use of pedicled tissue flap has less recurrence rate and fewer complications, and the difference between them is statistically significant [recurrence rate OR = 0.14, 95%CI (0.04, 0.47), P = 0.002; complications OR = 0.25, 95%CI (0.09, 0.66), P = 0.005]. Conclusions: The effect of using pedicled flaps in the repair of nasal septum perfo-ration is better than that of temporalis fascia, and it can be given priority in clinical treatment.