工艺热安全风险评估实践——氯硝柳胺制备过程酰胺化反应

Process Thermal Safety Risk Assessment Practice—Niclosamide Preparation Process Amidation Reaction

摘要: 药物氯硝柳胺的老药新用，使得其生产扩大规模。企业的精细化工生产工艺，各国政府对其热安全风险进行评估，以便安全管理。氯硝柳胺制备过程中，酰胺化反应是放热过程，站在企业生产安全的角度对原料、中间体和产品中的危险化学品进行分类，对酰胺化反应的工艺热安全进行风险评估。

Abstract: The new use of the drug chloronitrosamide has led to an expansion of its production. The fine chemical production process of enterprises, the governments assess their thermal safety risks for safe management. In the preparation process of niclosamide, the amidation reaction is an exothermic process, which classifies the hazardous chemicals in raw materials, intermediates and products from the perspective of enterprise production safety, and evaluates the process heat safety risk assessment of the amidation reaction.