岩白菜素作用及作用机制的研究进展
Research Progress on the Effect and Mechanism of Bergenin
DOI: 10.12677/PI.2022.113026, PDF,   
作者: 蔚晓晓, 夏玉凤*, 戴 岳*:中国药科大学,江苏 南京
关键词: 岩白菜素药理活性疾病Bergenin Pharmacological Activity Disease
摘要: 岩白菜素属于异香豆素类化合物,植物来源十分丰富。研究发现,岩白菜素具有多种药理活性,如抗炎、抗氧化、免疫调节、神经保护等。目前,已有相关药物复方岩白菜素片上市,临床上用于治疗慢性支气管炎。本文就岩白菜素的作用和作用机制做一简要综述。
Abstract: Bergenin belongs to isocoumarins, which are abundant in plant sources. Studies have found that bergenin has various pharmacological activities, such as anti-inflammatory, antioxidant, immune regulation, neuroprotection, etc. At present, there are related drugs compound bergenin tablets on the market, which are clinically used for the treatment of chronic bronchitis. In this article, a brief review of the effect and mechanism of bergenin is made.
文章引用:蔚晓晓, 夏玉凤, 戴岳. 岩白菜素作用及作用机制的研究进展[J]. 药物资讯, 2022, 11(3): 210-215. https://doi.org/10.12677/PI.2022.113026

参考文献

[1] 王刚, 麻兵继. 岩白菜素的研究概况[J]. 安徽中医学院学报, 2002, 21(6): 59-62.
[2] 董成梅, 杨丽川, 邹澄, 赵沛基, 蒲洪, 张滢. 岩白菜素的研究进展[J]. 昆明医学院学报, 2012, 33(1): 150-154.
[3] 田憬若, 谭秀山, 吴婷婷, 孙惜时, 谈甜甜, 任娇. 岩白菜素的生物活性的研究进展[J]. 食品研究与开发, 2014, 35(5): 128-132.
[4] 刘斌, 谭成玉, 池晓会, 陈宇婷, 韩梦迪, 波拉提•马卡比力. 岩白菜素的研究进展[J]. 西北药学杂志, 2015, 30(5): 660-662.
[5] 高辉, 黎云祥, 权秋梅, 王辉. 药用植物中岩白菜素提取工艺的研究进展[J]. 光谱实验室, 2013, 30(1): 93-97.
[6] Yang, S., Yu, Z., Wang, L., et al. (2017) The Natural Product Bergenin Ameliorates Lipopolysaccha-ride-Induced Acute Lung Injury by Inhibiting NF-κBactivition. Journal of Ethnopharmacology, 200, 147-155. [Google Scholar] [CrossRef] [PubMed]
[7] Chen, M., Chen, C., Gao, Y., et al. (2020) Bergenin-Activated SIRT1 Inhibits TNF-α-Induced Proinflammatory Response by Blocking the NF-κB Signaling Pathway. Pulmonary Pharmacology & Therapeutics, 62, Article ID: 101921. [Google Scholar] [CrossRef] [PubMed]
[8] Jing, L., Su, S., Zhang, D., et al. (2019) SroloBzhtang, a Tradi-tional Tibetan Medicine Formula, Inhibits Cigarette Smoke Induced Airway Inflammation and muc5ac Hypersecretion via Suppressing IL-13/STAT6 Signaling Pathway in Rats. Journal of Ethnopharmacology, 235, 424-434. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, K., Li, Y.F., Lv, Q., et al. (2017) Bergenin, Acting as an Agonist of PPARγ, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-κB-Mediated Macrophage Activation. Frontiers in Pharmacology, 8, Article No. 981. [Google Scholar] [CrossRef] [PubMed]
[10] Lopes De Oliveira, G.A., Alarcón De La Lastra, C., Rosillo, M., et al. (2019) Preventive Effect of Bergenin against the Development of TNBS-Induced Acute Colitis in Rats Is Associated with Inflammatory Mediators Inhibition and NLRP3/ASC Inflammasome Signaling Pathways. Chemico-Biological In-teraction, 297, 25-33. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, Y.H., Fang, L.H., Lee, M.K., et al. (2003) In Vitro Inhibitory Effects of Bergenin and Norbergenin on Bovine Adrenal Tyrosine Hydroxylase. Phytotherapy Research, 17, 967-969. [Google Scholar] [CrossRef] [PubMed]
[12] Yang, J., Kan, M. and Wu, G.Y. (2016) Bergenin Ameliorates Diabetic Nephropathy in Rats via Suppressing Renal Inflammation and TGF-β1-Smads Pathway. Immunopharmacology and Immunotoxicology, 38, 145-152. [Google Scholar] [CrossRef] [PubMed]
[13] Rajput, S.A., Mirza, M.R. and Choudhary, M.I. (2020) Ber-genin Protects Pancreatic Beta Cells against Cytokine-Induced Apoptosis in INS-1E Cells. PLoS ONE, 15, Article ID: e0241349. [Google Scholar] [CrossRef] [PubMed]
[14] Qiao, S., Liu, R., Lv, C., et al. (2019) Bergenin Impedes the Generation of Extracellular Matrix in Glomerular Mesangial Cells and Ameliorates Diabetic Nephropathy in Mice by In-hibiting Oxidative Stress via the mTOR/β-TrcP/Nrf2 Pathway. Free Radical Biology & Medicine, 145, 118-135. [Google Scholar] [CrossRef] [PubMed]
[15] Suh, K.S., Chon, S., Jung, W.W., et al. (2019) Effect of Bergenin on RANKL-Induced Osteoclast Differentiation in the Presence of Methylglyoxal. Toxicology in Vitro, 61, Arti-cle ID: 104613. [Google Scholar] [CrossRef] [PubMed]
[16] Lee, K.H. and Choi, E.M. (2018) Effects of Ber-genin on Methylglyoxal-Induced Damage in Osteoblastic MC3T3-E1 cells. Journal of Applied Toxicology, 38, 585-593. [Google Scholar] [CrossRef] [PubMed]
[17] Villarreal, C.F., Santos, D.S., Lauria, P.S.S., et al. (2020) Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System. Inter-national Journal of Molecular Sciences, 21, Article No. 4850. [Google Scholar] [CrossRef] [PubMed]
[18] Kumar, R., Patel, D.K., Prasad, S.K., et al. (2012) Type 2 Antidiabetic Activity of Bergenin from the Roots of Caesalpinia digyna Rottler. Fitoterapia, 83, 395-401. [Google Scholar] [CrossRef] [PubMed]
[19] Prabhakar, P.K., Singh, K., Kabra, D., et al. (2020) Natural SIRT1 Modifiers as Promising Therapeutic Agents for Improving Diabetic Wound Healing. Phytomedicine, 76, Article ID: 153252. [Google Scholar] [CrossRef] [PubMed]
[20] Rao, K., Roome, T., Aziz, S., et al. (2018) Bergenin Loaded Gum Xanthan Stabilized Silver Nanoparticles Suppress Synovial Inflammation through Modulation of the Immune Re-sponse and Oxidative Stress in Adjuvant Induced Arthritic Rats. Journal of Materials Chemistry B, 6, 4486-4501. [Google Scholar] [CrossRef
[21] El-Hawary, S.S., Mohammed, R., Abouzid, S., et al. (2016) An-ti-Arthritic Activity of 11-O-(4’-O-methyl galloyl)-Bergenin and Crassula capitella Extract in Rats. Journal of Pharmacy and Pharmacology, 68, 834-844. [Google Scholar] [CrossRef] [PubMed]
[22] Barai, P., Raval, N., Acharya, S., et al. (2019) Neuroprotective Effects of Bergenin in Alzheimer’s Disease: Investigation through Molecular Docking, in Vitro and in Vivo Studies. Behavioural Brain Research, 356, 18-40. [Google Scholar] [CrossRef] [PubMed]
[23] Ji, Y., Wang, D., Zhang, B., et al. (2019) Bergenin Ameliorates MPTP-Induced Parkinson’s Disease by Activating PI3K/Akt Signaling Pathway. Journal of Alzheimer’s Disease, 72, 823-833. [Google Scholar] [CrossRef
[24] Yun, J., Lee, Y., Yun, K., et al. (2015) Bergenin Decreases the Morphine-Induced Physical Dependence via Antioxidative Activity in Mice. Archives of Pharmacal Research, 38, 1248-1254. [Google Scholar] [CrossRef] [PubMed]
[25] Xiang, S., Chen, K., Xu, L., et al. (2020) Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Design, Development and Therapy, 14, 129-143. [Google Scholar] [CrossRef
[26] Xia, Y., Li, J., Chen, K., et al. (2020) Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway. PPAR Research, 2020, Article ID: 6694214. [Google Scholar] [CrossRef] [PubMed]
[27] Aggarwal, D., Gautam, D., Sharma, M., et al. (2016) Ber-genin Attenuates Renal Injury by Reversing Mitochondrial Dysfunction in Ethylene Glycol Induced Hyperoxaluric Rat Model. European Journal of Pharmacology, 791, 611-621. [Google Scholar] [CrossRef] [PubMed]
[28] Chen, M., Ye, C., Zhu, J., et al. (2020) Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia. Frontiers in Cell and Developmental Biology, 8, Article No. 703. [Google Scholar] [CrossRef] [PubMed]
[29] Qi, Q., Dong, Z., Sun, Y., et al. (2018) Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice. Molecules, 23, Article No. 2668. [Google Scholar] [CrossRef] [PubMed]
[30] Kumar, S., Sharma, C., Kaushik, S.R., et al. (2019) The Phyto-chemical Bergenin as an Adjunct Immunotherapy for Tuberculosis in Mice. Journal of Biological Chemistry, 294, 8555-8563. [Google Scholar] [CrossRef
[31] Liu, J., Zhang, Y., Yu, C., et al. (2021) Bergenin In-hibits Bladder Cancer Progression via Activating the PPARγ/PTEN/Akt Signal Pathway. Drug Development Research, 82, 278-286. [Google Scholar] [CrossRef] [PubMed]
[32] Shi, X., Xu, M., Luo, K., et al. (2019) Anticancer Activity of Bergenin against Cervical Cancer Cells Involves Apoptosis, Cell Cycle Arrest, Inhibition of Cell Migration and the STAT3 Signalling Pathway. Experimental and Therapeutic Medicine, 17, 3525-3529. [Google Scholar] [CrossRef] [PubMed]
[33] Jayakody, R.S., Wijewardhane, P., Herath, C., et al. (2018) Bergenin: A Computationally Proven Promising Scaffold for Novel Galectin-3 Inhibitors. Journal of Molecular Modeling, 24, Ar-ticle No. 302. [Google Scholar] [CrossRef] [PubMed]