基于CiteSpace分析、GC-MS和网络药理学探讨地瓜藤抗氧化的成分及其作用机制

The Antioxidant Components and Mechanism of Ficus tikoua Bur. Were Discussed Based on CiteSpace Analysis, GC-MS and Network Pharmacology

摘要: 目的：基于CiteSpace分析、GC-MS和网络药理学探讨地瓜藤抗氧化的成分及其作用机制。方法：以中国知网数据库(CNKI)中收录的地瓜藤相关文献为依据，运用CiteSpace软件对作者、机构、关键词进行可视化分析。进一步，将GC-MS技术分析鉴定出的地瓜藤成分和文献报道成分纳入研究，并借助TCMSP和Swiss Target Prediction数据库收集成分对应靶点，使用Cytoscape软件对其进行可视化分析和筛选，再进行KEGG通路分析。结果：共纳入文献112篇，研究团队以刘燕团队和叶林团队等为核心，研究机构主要以云南中医学院和贵州中医药大学等为核心。关键词聚类分析显示，研究热点主要集中在抗氧化、扦插和质地等方面。经GC-MS鉴别和文献整理，筛选得到地瓜藤抗氧化活性成分43个，包括槲皮素、柚皮素、芹菜素和木犀草素等，涉及52个靶点，可能是通过Pathways in cancer、Lipid and atherosclerosis等信号通路来发挥抗氧化作用。结论：通过可视化分析，直观地展现出地瓜藤的研究团队、机构和研究热点。在此基础上，利用网络药理学发现地瓜藤可能通过多成分、多靶点和多通路来发挥抗氧化的作用，研究结果可为阐明地瓜藤抗氧化的物质基础和作用机制提供依据。

Abstract: Objective: Based on CiteSpace analysis, GC-MS and network pharmacology, to explore the antioxidant components and mechanism of Ficus tikoua Bur. Methods: Based on the relevant literature of Ficus tikoua Bur. collected in CNKI database, the author, organization and keywords were visually analyzed by CiteSpace software. Further, the components of Ficus tikoua Bur. and literature reported components identified by GC-MS technology were included in the study, and the corresponding targets of components were collected with the help of TCMSP and Swiss target prediction database, which were visually analyzed and screened by Cytoscape software, and then analyzed by KEGG pathway. Results: A total of 112 literatures were included. The research team took Liu Yan’s team and Ye Lin’s team as the core, and the research institutions mainly took Yunnan University of traditional Chinese medicine and Guizhou University of traditional Chinese medicine as the core. Keyword cluster analysis showed that the research hotspots mainly focused on antioxidant, cutting and texture. After GC-MS identification and literature sorting, 43 antioxidant active components of Ficus tikoua Bur. were screened, including quercetin, naringin, apigenin and luteolin, involving 52 targets, which may play an antioxidant role through pathways in cancer, lipid and atherosclerosis. Conclusion: Through visual analysis, the research team, institutions and research hotspots of Ficus tikoua Bur. are intuitively displayed. On this basis, using network pharmacology, it is found that Ficus tikoua Bur. may play an antioxidant role through multi-component, multi-target and multi-channel. The research results can provide a basis for clarifying the material basis and action mechanism of anti-oxidation of Ficus tikoua Bur.