中、藏药对阿尔兹海默病干预的研究进展
Research Progress of Chinese and Tibetan Medicine on Alzheimer’s Disease Intervention
DOI: 10.12677/ACM.2022.1281058, PDF,    国家科技经费支持
作者: 刘文增：青海大学研究生院，青海 西宁；朱爱琴*：青海省人民医院老年医学研究所，青海 西宁
关键词: 痴呆；阿尔茨海默病；传统中药；藏药；β-淀粉样蛋白；Dementia； Alzheimer’s Disease； Traditional Chinese Medicine； Tibetan Medicine； β-Amyloid
摘要: 阿尔茨海默病(AD)是一种不可逆转的神经退行性疾病，是老年人痴呆最常见的病因，约占所有痴呆比例的80%，临床表现为两个或多个认知领域(记忆力、语言、执行力和视觉空间功能、人格和行为)的进行性下降。当下尚无可以根治AD的药物。而传统中、藏药在防治AD上具有显著的优势。近年来，越来越多的国内外中、藏药干预AD发病机制的研究显示其主要通过抑制β-淀粉样蛋白聚集及Tau蛋白过度磷酸化、抑制氧化应激反应及清除自由基、改善胆碱能系统学说等方面，来保护神经元，可以有效地延缓和抑制AD的发生发展。本文将传统中、藏药及复方制剂干预AD的研究进展做一综述。
Abstract: Alzheimer’s disease (AD), an irreversible neurodegenerative disease, is the most common cause of dementia in the elderly, accounting for about 80% of all dementias, with clinical manifestations in two or more cognitive domains (memory, language, executive and visuospatial function, personality and behavior) progressive decline. There are currently no drugs that can cure AD. Traditional Chi-nese and Tibetan medicines have significant advantages in the prevention and treatment of AD. In recent years, more and more domestic and foreign studies on the intervention of Chinese and Ti-betan medicine on the pathogenesis of AD have shown that it mainly inhibits β-amyloid protein ag-gregation and Tau protein hyperphosphorylation, inhibits oxidative stress response, scavenges free radicals, improves biliary Alkaline system theory and other aspects, to protect neurons, can effec-tively delay and inhibit the occurrence and development of AD. This article reviews the research progress of traditional Chinese and Tibetan medicines and compound preparations in AD interven-tion.
文章引用：刘文增, 朱爱琴. 中、藏药对阿尔兹海默病干预的研究进展[J]. 临床医学进展, 2022, 12(8): 7326-7331. https://doi.org/10.12677/ACM.2022.1281058

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