恶性肿瘤相关性静脉血栓的形成及评估现状
Current Status of Formation and Evaluation of Malignant Tumor Related Venous Throm-bosis
DOI: 10.12677/ACM.2023.1351032, PDF,   
作者: 陈 婷:青海大学研究生院,青海 西宁;李 燕*:青海大学附属医院肿瘤内科,青海 西宁
关键词: 恶性肿瘤相关性静脉血栓评估模型Malignant Tumor Associated Venous Thrombosis Evaluation Model
摘要: 癌症患者比非癌症患者更易发生静脉血栓,总结现有文献,以准确地确定癌症患者静脉血栓栓塞症(Venous thromboembolism, VTE)发生的相关危险因素,对当前普适性VTE评估模型进行简单阐述,结合现有的评估模型,按恶性肿瘤部位和VTE的背景风险进行分层,对未来构建出适合我国恶性肿瘤患者VTE的防治奠定基础。
Abstract: Cancer patients are more likely to develop venous thrombosis than non cancer patients. Summarize the existing literature to accurately identify the relevant risk factors for venous thromboembolism in cancer patients, briefly describe the current universal VTE evaluation model, and combine the existing evaluation model to stratify according to the location of malignant tumors and the back-ground risk of VTE, laying the foundation for the future construction of VTE prevention and treat-ment suitable for malignant tumor patients in China.
文章引用:陈婷, 李燕. 恶性肿瘤相关性静脉血栓的形成及评估现状[J]. 临床医学进展, 2023, 13(5): 7393-7401. https://doi.org/10.12677/ACM.2023.1351032

参考文献

[1] Faiz, A.S., Khan, I., Beckman, M.G., et al. (2015) Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism. Thrombosis Research, 136, 535-541. [Google Scholar] [CrossRef] [PubMed]
[2] Blom, J.W., Doggen, C.J.M., Osanto, S. and Rosendaal, F.R. (2005) Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis. JAMA, 293, 715-722. [Google Scholar] [CrossRef] [PubMed]
[3] Lyman, G.H., Culakova, E., Poniewierski, M.S. and Kuderer, N.M. (2018) Morbidity, Mortality and Costs Associated with Venous Thromboembolism in Hospitalized Patients with Cancer. Thrombosis Research, 164, S112-S118. [Google Scholar] [CrossRef] [PubMed]
[4] Reitsma, P.H., Versteeg, H.H. and Middeldorp, S. (2012) Mechanistic View of Risk Factors for Venous Thromboembolism. Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 563-568. [Google Scholar] [CrossRef
[5] 张尤磊, 王道荣, 汤东. 胃癌围手术期静脉血栓形成机制的研究进展[J]. 中华普外科手术学杂志(电子版), 2019, 13(5): 534-536.
[6] Nasser, N.J., Fox, J. and Agbarya, A. (2020) Potential Mechanisms of Cancer-Related Hypercoagulability. Cancers, 12, Article No. 566. [Google Scholar] [CrossRef] [PubMed]
[7] Horsted, F., West, J. and Grainge, M.J. (2012) Risk of Venous Thromboembolism in Patients with Cancer: A Systematic Review and Meta-Analysis. PLOS Medicine, 9, e1001275. [Google Scholar] [CrossRef] [PubMed]
[8] Mahajan, A., Brunson, A., White, R. and Wun, T. (2019) The Epidemiology of Cancer-Associated Venous Thromboembolism: An Update. Seminars in Thrombosis and Hemostasis, 45, 321-325. [Google Scholar] [CrossRef] [PubMed]
[9] Blom, J.W., Osanto, S. and Rosendaal, F.R. (2004) The Risk of a Venous Thrombotic Event in Lung Cancer Patients: Higher Risk for Adenocarcinoma Than Squamous Cell Carcinoma. Journal of Thrombosis and Haemostasis: JTH, 2, 1760-1765. [Google Scholar] [CrossRef] [PubMed]
[10] Cohen, A.T., Katholing, A., Rietbrock, S., Bamber, L. and Martinez, C. (2017) Epidemiology of First and Recurrent Venous Thromboembolism in Patients with Active Cancer: A Population-Based Cohort Study. Thrombosis and Haemostasis, 117, 57-65. [Google Scholar] [CrossRef
[11] Martinez, C., Cohen, A.T., Bamber, L. and Rietbrock, S. (2014) Epi-demiology of First and Recurrent Venous Thromboembolism: A Population-Based Cohort Study in Patients without Ac-tive Cancer. Thrombosis and Haemostasis, 112, 255-263. [Google Scholar] [CrossRef
[12] Overvad, T.F., Ording, A.G., Nielsen, P.B., et al. (2022) Validation of the Khorana Score for Predicting Venous Thromboembo-lism in 40 218 Patients with Cancer Initiating Chemotherapy. Blood Advances, 6, 2967-2976. [Google Scholar] [CrossRef] [PubMed]
[13] Blom, J.W., Vanderschoot, J.P.M., Oostindiër, M.J., et al. (2006) Incidence of Venous Thrombosis in a Large Cohort of 66,329 Cancer Patients: Results of a Record Linkage Study. Journal of Thrombosis and Haemostasis: JTH, 4, 529-535. [Google Scholar] [CrossRef] [PubMed]
[14] Fotopoulou, C., DuBois, A., Karavas, A.N., et al. (2008) Incidence of Venous Thromboembolism in Patients with Ovarian Cancer Undergoing Platinum/Paclitaxel–Containing First-Line Chemotherapy: An Exploratory Analysis by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group. Journal of Clinical Oncology, 26, 2683-2689. [Google Scholar] [CrossRef
[15] Chavan, D.M., Huang, Z., Song, K., et al. (2017) Incidence of Venous Thromboembolism Following the Neoadjuvant Chemotherapy Regimen for Epithelial Type of Ovarian Cancer. Medicine, 96, e7935. [Google Scholar] [CrossRef
[16] Fotopoulou, C., Karavas, A., Trappe, R., et al. (2009) Ve-nous Thromboembolism in Recurrent Ovarian Cancer-Patients: A Systematic Evaluation of the North-Eastern German Society of Gynaecologic Oncology Ovarian Cancer Study Group (NOGGO). Thrombosis Research, 124, 531-535. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, Y., Gao, Y., Wei, L., et al. (2015) Peripherally Inserted Central Catheter Thrombosis Incidence and Risk Factors in Cancer Patients: A Double-Center Prospective Investigation. Therapeutics and Clinical Risk Management, 11, 153-160. [Google Scholar] [CrossRef
[18] Kang, J.R., Long, L.H., Yan, S.W., et al. (2017) Peripherally Inserted Central Catheter-Related Vein Thrombosis in Patients with Lung Cancer. Clinical and Applied Thrombosis/Hemostasis, 23, 181-186. [Google Scholar] [CrossRef] [PubMed]
[19] Bistervels, I.M., Scheres, L.J.J., Hamulyák, E.N. and Middeldorp, S. (2019) Sex Matters: Practice 5P’s When Treating Young Women with Venous Thromboembolism. Journal of Thrombosis and Haemostasis: JTH, 17, 1417-1429. [Google Scholar] [CrossRef] [PubMed]
[20] Palareti, G., Legnani, C., Antonucci, E., et al. (2020) D-Dimer Testing, with Gender-Specific Cutoff Levels, Is of Value to Assess the Individual Risk of Venous Thromboembolic Recurrence in Non-Elderly Patients of Both Genders: A Post Hoc Analysis of the DULCIS Study. Internal and Emergency Medicine, 15, 453-462. [Google Scholar] [CrossRef] [PubMed]
[21] Hotoleanu, C. (2020) Association between Obesity and Venous Thromboembolism. Medicine and Pharmacy Reports, 93, 162-168. [Google Scholar] [CrossRef] [PubMed]
[22] White, R.H. (2003) The Epidemiology of Venous Thromboembolism. Circulation, 107, I-4-I-8. [Google Scholar] [CrossRef
[23] Zöller, B., Li, X., Ohlsson, H., et al. (2015) Family History of Venous Thromboembolism as a Risk Factor and Genetic Research Tool. Thrombosis and Haemostasis, 114, 890-900. [Google Scholar] [CrossRef
[24] Zöller, B., Li, X., Sundquist, J. and Sundquist, K. (2011) Age- and Gender-Specific Familial Risks for Venous Thromboembolism: A Nationwide Epidemiological Study Based on Hospitalizations in Sweden. Circulation, 124, 1012-1020. [Google Scholar] [CrossRef
[25] Entezari-Maleki, T., Hajhossein Talasaz, A., Salarifar, M., et al. (2014) Plasma Vitamin D Status and Its Correlation with Risk Factors of Thrombosis, P-Selectin and hs-CRP Level in Patients with Venous Thromboembolism; The First Study of Iranian Population. Iranian Journal of Pharmaceutical Research: IJPR, 13, 319-327.
[26] 曲洪雪, 刘云鹏. 骨科深静脉血栓形成危险因素及发病机制的研究进展[J]. 中国矫形外科杂志, 2009, 17(2): 110-112.
[27] 姚杰, 孟尽海, 王文娟, 等. 骨科手术病人术后下肢深静脉血栓形成的危险因素[J]. 中华麻醉学杂志, 2013, 33(4): 413-416.
[28] Kearon, C., Spencer, F.A., O’Keeffe, D., et al. (2015) D-Dimer Testing to Select Patients with a First Unprovoked Venous Thromboembolism Who Can Stop Anticoagulant Therapy. Annals of Internal Medicine, 162, 27-34. [Google Scholar] [CrossRef
[29] Wang, J., Tacey, M. and Ho, P. (2020) Retrospective Review of D-Dimer Testing for Venous Thrombosis Recurrence Risk Stratification: Is This a Useful Test in the Real World? Journal of Thrombosis and Thrombolysis, 49, 562-571. [Google Scholar] [CrossRef] [PubMed]
[30] Antonopoulos, C.N., Sfyroeras, G.S., Kakisis, J.D., Moulakakis, K.G. and Liapis, C.D. (2014) The Role of Soluble P Selectin in the Diagnosis of Venous Thromboembolism. Throm-bosis Research, 133, 17-24. [Google Scholar] [CrossRef] [PubMed]
[31] Kollias, A., Kyriakoulis, K.G., Lagou, S., et al. (2021) Venous Thromboembolism in COVID-19: A Systematic Review and Meta-Analysis. Vascular Medicine, 26, 415-425. [Google Scholar] [CrossRef
[32] Liu, Y., Cai, J., Wang, C., Jin, J. and Qu, L. (2021) A Systematic Review and Meta-Analysis of Incidence, Prognosis, and Laboratory Indicators of Venous Thromboembolism in Hospi-talized Patients with Coronavirus Disease 2019. Journal of Vascular Surgery. Venous and Lymphatic Disorders, 9, 1099-1111. [Google Scholar] [CrossRef] [PubMed]
[33] Caprini, J.A. (2010) Risk Assessment as a Guide to Thrombosis Prophylaxis. Current Opinion in Pulmonary Medicine, 16, 448-452. [Google Scholar] [CrossRef
[34] Cronin, M., Dengler, N., Krauss, E.S., et al. (2019) Com-pletion of the Updated Caprini Risk Assessment Model (2013 version). Clinical and Applied Thrombosis/Hemostasis, 25, Article ID: 1076029619838052. [Google Scholar] [CrossRef] [PubMed]
[35] Spyropoulos, A.C., Anderson, F.A., FitzGerald, G., et al. (2011) Predictive and Associative Models to Identify Hospitalized Medical Patients at Risk for VTE. CHEST, 140, 706-714. [Google Scholar] [CrossRef] [PubMed]
[36] Al-Ogaili, A., Fuentes, H.E., Tafur, A.J. and Caprini, J. (2018) Risk Assessment as a Guide for the Prevention of Cancer-Associated Thromboembolism. International Angiology, 37, 269-276.
[37] 徐留海, 曾勇, 黄卫, 等. 基于Caprini血栓风险模型评估膝关节镜手术患者深静脉血栓形成的风险性[J]. 中国组织工程研究, 2016, 20(17): 2474-2480.
[38] Kahn, S.R., Lim, W., Dunn, A.S., et al. (2012) Preven-tion of VTE in Nonsurgical Patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST, 141, e195S-e226S. https://pubmed.ncbi.nlm.nih.gov/22315261/ [Google Scholar] [CrossRef] [PubMed]
[39] Khorana, A.A., Kuderer, N.M., Culakova, E., Lyman, G.H. and Francis, C.W. (2008) Development and Validation of a Predictive Model for Chemotherapy-Associated Thrombosis. Blood, 111, 4902-4907. [Google Scholar] [CrossRef] [PubMed]
[40] Frere, C., Wahl, C., Rueda-Camino, J.A., et al. (2022) A Re-view of Latest Clinical Practice Guidelines for the Management of Cancer-Associated Thrombosis. Best Practice & Re-search Clinical Haematology, 35, Article ID: 101348. [Google Scholar] [CrossRef] [PubMed]
[41] Streiff, M. B., Holmstrom, B., Angelini, D., et al. (2021) Can-cer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 19, 1181-1201.
[42] Key, N.S., Khorana, A.A., Kuderer, N.M., et al. (2020) Venous Thromboembolism Prophylaxis and Treatment in Patients with Cancer: ASCO Clinical Prac-tice Guideline Update. Journal of Clinical Oncology, 38, 496-520. [Google Scholar] [CrossRef
[43] Mulder, F.I., Candeloro, M., Kamphuisen, P.W., et al. (2019) The Khorana Score for Prediction of Venous Thromboembolism in Cancer Patients: A Systematic Review and Meta-Analysis. Haematologica, 104, 1277-1287. [Google Scholar] [CrossRef] [PubMed]
[44] Dapkevičiūtė, A., Daškevičiūtė, A., Zablockis, R., et al. (2020) Association between the Khorana Score and Pulmonary Embolism Risk in Patients with Advanced Stage Lung Cancer. The Clinical Respiratory Journal, 14, 3-8. [Google Scholar] [CrossRef] [PubMed]
[45] Barbar, S., Noventa, F., Rossetto, V., et al. (2010) A Risk Assessment Model for the Identification of Hospitalized Medical Patients at Risk for Venous Thromboembolism: The Padua Predic-tion Score. Journal of Thrombosis and Haemostasis: JTH, 8, 2450-2457. [Google Scholar] [CrossRef] [PubMed]