系统性红斑狼疮患者宫颈HPV感染特点及疫苗安全性研究进展
Research Progress on Cervical HPV Infection Characteristics and Vaccine Safety in Patients with Systemic Lupus Erythematosus
DOI: 10.12677/ACM.2023.13122799, PDF,   
作者: 倪 智, 熊正爱*:重庆医科大学附属第二医院妇产科,重庆
关键词: SLEHPV感染宫颈病变HPV疫苗SLE HPV Infection Cervical Lesions HPV Vaccine
摘要: 高危型HPV持续感染与宫颈癌和宫颈癌前病变密切相关,HPV的清除与机体的免疫功能有关。SLE患者由于自身免疫系统紊乱,发生HPV感染及宫颈病变的风险增加。HPV疫苗极大降低HPV感染的风险,对于SLE患者应积极接种HPV疫苗。本文综述系统性红斑狼疮患者宫颈HPV感染特点及疫苗安全性相关研究进展,为SLE患者宫颈癌筛查及HPV疫苗相关接种及研发提供参考。
Abstract: The persistent infection of high-risk HPV is closely related to cervical cancer and cervical precan-cerous lesions, and the clearance of HPV is related to the immune function of the body. Patients with SLE are at increased risk of HPV infection and cervical lesions due to autoimmune disorders. HPV vaccine greatly reduces the risk of HPV infection and should be actively vaccinated in SLE patients. This article reviewed the characteristics of cervical HPV infection in patients with systemic lupus erythematosus and the relevant research progress of vaccine safety, so as to provide references for cervical cancer screening and HPV vaccine related vaccination and research and development in SLE patients.
文章引用:倪智, 熊正爱. 系统性红斑狼疮患者宫颈HPV感染特点及疫苗安全性研究进展[J]. 临床医学进展, 2023, 13(12): 19870-19877. https://doi.org/10.12677/ACM.2023.13122799

参考文献

[1] Torres-Poveda, K., Ruiz-Fraga, I., Madrid-Marina, V., et al. (2019) High Risk HPV Infection Prevalence and Associated Cofactors: A Population-Based Study in Female ISSSTE Beneficiaries Attending the HPV Screening and Early Detection of Cervical Cancer Program. BMC Cancer, 19, Article No. 1205. [Google Scholar] [CrossRef] [PubMed]
[2] 俞佳敏, 邢燕. 系统免疫性疾病与宫颈病变[J]. 现代妇产科进展, 2021, 30(11): 863-865.
[3] García-Carrasco, M., Mendoza-Pinto, C., Rojas-Villarraga, A., et al. (2019) Prevalence of Cervical HPV Infection in Women with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis. Autoimmunity Reviews, 18, 184-191. [Google Scholar] [CrossRef] [PubMed]
[4] Zard, E., Arnaud, L., Mathian, A., et al. (2014) Increased Risk of High Grade Cervical Squamous Intraepithelial Lesions in Systemic Lupus Erythematosus: A Meta-Analysis of the Liter-ature. Autoimmunity Reviews, 13, 730-735. [Google Scholar] [CrossRef] [PubMed]
[5] Santana, I.U., Gomes Ado, N., Lyrio, L.D., et al. (2011) Sys-temic Lupus Erythematosus, Human Papillomavirus Infection, Cervical Pre-Malignant and Malignant Lesions: A Sys-tematic Review. Clinical Rheumatology, 30, 665-672. [Google Scholar] [CrossRef] [PubMed]
[6] Rojo-Contreras, W., Olivas-Flores, E.M., Gamez-Nava, J.I., et al. (2012) Cervical Human Papillomavirus Infection in Mexican Women with Systemic Lupus Erythematosus or Rheuma-toid Arthritis. Lupus, 21, 365-372. [Google Scholar] [CrossRef] [PubMed]
[7] 王银浩, 谢通, 刘栩, 等. 女性系统性红斑狼疮患者HPV感染特点及疫苗安全性的研究现状[J]. 现代妇产科进展, 2018, 27(6): 462-464.
[8] Bruni, L., Diaz, M., Castellsagué, X., et al. (2010) Cervical Human Papillomavirus Prevalence in 5 Continents: Meta- Analysis of 1 Million Women with Normal Cytological Findings. The Journal of Infectious Diseases, 202, 1789-1799. [Google Scholar] [CrossRef] [PubMed]
[9] 陈琦, 富诗岚, 徐慧芳, 等. 中国大陆女性HPV感染危险因素的Meta分析[J]. 中国微生态学杂志, 2022, 34(6): 657-664.
[10] Amaral, J.L., Araújo, M.V., Dias, G.A., et al. (2017) Clinical and Epidemiological Study of Human Papillomavirus Infection in Women with Systemic Lupus Erythematosus in Eastern Brazilian Amazon. Acta Reumatologica Portuguesa, 42, 47-54.
[11] Tam, L.S., Chan, A.Y., Chan, P.K., et al. (2004) Increased Prevalence of Squamous Intraepithelial Lesions in Systemic Lupus Erythematosus: Association with Human Papillomavirus Infection. Arthritis and Rheumatism, 50, 3619-3625. [Google Scholar] [CrossRef] [PubMed]
[12] Tam, L.S., Chan, P.K., Ho, S.C., et al. (2010) Natural History of Cervical Papilloma Virus Infection in Systemic Lupus Erythematosus—A Prospective Cohort Study. The Journal of Rheumatol-ogy, 37, 330-340. [Google Scholar] [CrossRef] [PubMed]
[13] Mendoza-Pinto, C., García-Carrasco, M., Vallejo-Ruiz, V., et al. (2017) Incidence of Cervical Human Papillomavirus Infection in Systemic Lupus Erythematosus Women. Lupus, 26, 944-951. [Google Scholar] [CrossRef] [PubMed]
[14] 李双, 孔北华. 人乳头瘤病毒疫苗临床应用中国专家共识(2021年版)解读[J]. 实用妇产科杂志, 2022, 38(11): 827-831.
[15] Foster, E., Malloy, M.J., Jokubaitis, V.G., et al. (2020) Increased Risk of Cervical Dysplasia in Females with Autoimmune Conditions—Results from an Australia Data-base Linkage Study. PLOS ONE, 15, e0234813. [Google Scholar] [CrossRef] [PubMed]
[16] 张延玲, 高燕云. 系统免疫性疾病女性患者宫颈癌及癌前病变的风险研究[J]. 中国性科学, 2017, 26(6): 38-41.
[17] Rees, F., Doherty, M., Grainge, M.J., et al. (2017) The Worldwide Incidence and Prevalence of Systemic Lupus Erythematosus: A Systematic Review of Epidemiological Stud-ies. Rheumatology (Oxford, England), 56, 1945-1961. [Google Scholar] [CrossRef] [PubMed]
[18] Feldman, C.H., Liu, J., Feldman, S., et al. (2017) Risk of High-Grade Cervical Dysplasia and Cervical Cancer in Women with Systemic Lupus Erythematosus Receiving Immu-nosuppressive Drugs. Lupus, 26, 682-689. [Google Scholar] [CrossRef] [PubMed]
[19] Dreyer, L., Faurschou, M., Mogensen, M., et al. (2011) High In-cidence of Potentially Virus-Induced Malignancies in Systemic Lupus Erythematosus: A Long-Term Follow-Up Study in a Danish Cohort. Arthritis and Rheumatism, 63, 3032-3037. [Google Scholar] [CrossRef] [PubMed]
[20] Cocchio, S., Bertoncello, C., Baldovin, T., et al. (2020) Awareness of HPV and Drivers of HPV Vaccine Uptake among University Students: A Quantitative, Cross-Sectional Study. Health & Social Care in the Community, 28, 1514-1524. [Google Scholar] [CrossRef] [PubMed]
[21] 狄娜, 刘应南, 张建欣, 等. HPV知晓度和HPV疫苗接受度问卷调查情况研究进展[J]. 中国全科医学, 2020, 23(13): 1675-1679.
[22] David, E., Roy, P., Belot, A., et al. (2022) Human Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Driv-ers of Vaccination. Journal of Clinical Medicine, 11, Article No. 4137. [Google Scholar] [CrossRef] [PubMed]
[23] Dhar, J.P., Essenmacher, L., Dhar, R., et al. (2019) Lack of Uptake of Prophylactic Human Papilloma Virus Vaccine among Women with Systemic Lupus Erythematosus Seen at a Regional Medical Center. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, 25, 348-350. [Google Scholar] [CrossRef
[24] Chehab, G., Richter, J.G., Brinks, R., et al. (2018) Vaccina-tion Coverage in Systemic Lupus Erythematosus—A Cross- Sectional Analysis of the German Long-Term Study (LuLa Cohort). Rheumatology (Oxford, England), 57, 1439-1447. [Google Scholar] [CrossRef] [PubMed]
[25] Andreoli, L., Bertsias, G.K., Agmon-Levin, N., et al. (2017) EULAR Recommendations for Women’s Health and the Management of Family Planning, Assisted Reproduction, Preg-nancy and Menopause in Patients with Systemic Lupus Erythematosus and/or Antiphospholipid Syndrome. Annals of the Rheumatic Diseases, 76, 476-485. [Google Scholar] [CrossRef] [PubMed]
[26] Furer, V., Rondaan, C., Heijstek, M.W., et al. (2020) 2019 Update of EULAR Recommendations for Vaccination in Adult Patients with Autoimmune Inflammatory Rheumatic Dis-eases. Annals of the Rheumatic Diseases, 79, 39-52. [Google Scholar] [CrossRef] [PubMed]
[27] Setiawan, D., Luttjeboer, J., Pouwels, K.B., et al. (2017) Immunogenicity and Safety of Human Papillomavirus (HPV) Vaccination in Asian Populations from Six Countries: A Meta-Analysis. Japanese Journal of Clinical Oncology, 47, 265-276. [Google Scholar] [CrossRef] [PubMed]
[28] Grein, I.H., Groot, N., Lacerda, M.I., et al. (2016) HPV Infection and Vaccination in Systemic Lupus Erythematosus Patients: What We Really Should Know. Pediatric Rheumatology Online Journal, 14, Article No. 12. [Google Scholar] [CrossRef] [PubMed]
[29] Johnson, C.A., James, D., Marzan, A., et al. (2019) Cervical Cancer: An Overview of Pathophysiology and Management. Seminars in Oncology Nursing, 35, 166-174. [Google Scholar] [CrossRef] [PubMed]
[30] Moscicki, A.B., Flowers, L., Huchko, M.J., et al. (2019) Guide-lines for Cervical Cancer Screening in Immunosuppressed Women without HIV Infection. Journal of Lower Genital Tract Disease, 23, 87-101. [Google Scholar] [CrossRef
[31] Mok, C.C., Ho, L.Y., Fong, L.S., et al. (2013) Immunogen-icity and Safety of a Quadrivalent Human Papillomavirus Vaccine in Patients with Systemic Lupus Erythematosus: A Case-Control Study. Annals of the Rheumatic Diseases, 72, 659-664. [Google Scholar] [CrossRef] [PubMed]
[32] Mok, C.C., Ho, L.Y., Fong, L.S., et al. (2013) Immuno-genicity and Safety of a Quadrivalent Human Papillomavirus Vaccine in Patients with Systemic Lupus Erythematosus: A Case-Control Study. Annals of the Rheumatic Diseases, 72, 659-664. [Google Scholar] [CrossRef] [PubMed]
[33] Infante, V., Miyaji, K.T., Soarez, P.C., et al. (2021) Sys-tematic Review and Meta-Analysis of HPV Vaccination in Women with Systemic Lupus Erythematosus (SLE). Expert Review of Vaccines, 20, 309-318. [Google Scholar] [CrossRef] [PubMed]
[34] Lu, B., Kumar, A., Castellsagué, X., et al. (2011) Efficacy and Safety of Prophylactic Vaccines against Cervical HPV Infection and Diseases among Women: A Systematic Review & Meta-Analysis. BMC Infectious Diseases, 11, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[35] Slade, B.A., Leidel, L., Vellozzi, C., et al. (2009) Postlicensure Safety Surveillance for Quadrivalent Human Papillomavirus Recombinant Vaccine. JAMA, 302, 750-757. [Google Scholar] [CrossRef] [PubMed]
[36] Rotstein Grein, I.H., Pinto, N.F., Lobo, A., et al. (2020) Safety and Immunogenicity of the Quadrivalent Human Papillomavirus Vaccine in Patients with Childhood Systemic Lupus Ery-thematosus: A Real-World Interventional Multi-Centre Study. Lupus, 29, 934-942. [Google Scholar] [CrossRef] [PubMed]
[37] Agmon-Levin, N., Paz, Z., Israeli, E., et al. (2009) Vaccines and Autoimmunity. Nature Reviews Rheumatology, 5, 648-652. [Google Scholar] [CrossRef] [PubMed]
[38] Israeli, E., Agmon-Levin, N., Blank, M., et al. (2011) Macrophagic Myofaciitis a Vaccine (Alum) Autoimmune-Related Disease. Clinical Reviews in Allergy & Immunology, 41, 163-168. [Google Scholar] [CrossRef] [PubMed]
[39] Guo, Y., Shi, L., Hong, H., et al. (2013) Studies on Abacavir-Induced Hypersensitivity Reaction: A Successful Example of Translation of Pharmacogenetics to Personalized Medicine. Science China Life Sciences, 56, 119-124. [Google Scholar] [CrossRef] [PubMed]
[40] Bragazzi, N.L., Bridgewood, C., Sharif, K., et al. (2019) HPV Vaccines and Lupus: Current Approaches towards Preventing Adverse Immune Cross-Reactivity. Expert Review of Vac-cines, 18, 31-42. [Google Scholar] [CrossRef] [PubMed]
[41] Curry, S.J., Krist, A.H., Owens, D.K., et al. (2018) Screen-ing for Cervical Cancer: US Preventive Services Task Force Recommendation Statement. JAMA, 320, 674-686. [Google Scholar] [CrossRef] [PubMed]
[42] (2016) Practice Bulletin No. 167: Gynecologic Care for Women and Adolescents with Human Immunodeficiency Virus. Obstetrics and Gynecology, 128, e89-e110.