罕见嗜酸性肾细胞肿瘤的研究进展
Advances in Studying Rare Eosinophilic Renal Cell Tumors
DOI: 10.12677/acm.2024.143950, PDF,   
作者: 王 鹏, 李巧新*:新疆医科大学第一附属医院病理科,新疆 乌鲁木齐
关键词: 肾肿瘤嗜酸性胞浆免疫组织化学染色体靶向治疗Renal Tumor Eosinophilic Cytoplasm Immunohistochemistry Chromosomal Targeted Therapy
摘要: 常见的嗜酸性细胞浆可以出现在不同的肾肿瘤亚型之中,精确的诊断、熟悉掌握嗜酸性肾肿瘤亚型至关重要,然而日常工作中对遇到的嗜酸性肾肿瘤认识尚存争议。本文就不同的嗜酸性肾肿瘤亚型的临床病理学及分子病理学等方面的研究进展作一综述,以期对临床病理工作起帮助。
Abstract: Common eosinophilic cytoplasm can appear in different renal tumor subtypes, and it is crucial to accurately diagnose and be familiar with eosinophilic renal tumor subtypes. However, the understanding of eosinophilic renal tumors encountered in daily work is still controversial. This paper summarizes the progress of the clinical pathology and molecular pathology of different eosinophilic renal tumor subtypes, in order to help the clinical pathology.
文章引用:王鹏, 李巧新. 罕见嗜酸性肾细胞肿瘤的研究进展[J]. 临床医学进展, 2024, 14(3): 2105-2112. https://doi.org/10.12677/acm.2024.143950

参考文献

[1] Siegel, R.L., Miller, K.D., Fuchs, H.E., et al. (2022) Cancer Statistics, 2022. CA: A Cancer Journal for Clinicians, 72, 7-33. [Google Scholar] [CrossRef] [PubMed]
[2] Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020, GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[3] Zheng, R.S., Zhang, S.W., Zeng, H.M., Wang, S.M., et al. (2016) Cancer Incidence and Mortality in China. Journal of the National Cancer Center, 2, 1-9. [Google Scholar] [CrossRef] [PubMed]
[4] 周晓军, 余英豪, 等. 肾脏肿瘤[J]. 临床病理诊断与鉴别诊断-泌尿及男性生殖系统疾病, 2020, 8(1): 112-163.
[5] Williamson, S.R., Gill, A.J., Argani, P., et al. (2020) Report from the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: III: Molecular Pathology of Kidney Cancer. The American Journal of Surgical Pathology, 44, E47-E65. [Google Scholar] [CrossRef
[6] 宋雪雪, 许周毅, 丁晓琴, 等. 伴有极向反转的乳头状肾肿瘤一例[J]. 中华病理学杂志, 2020(4): 358-360.
[7] Michalova, K., Steiner, P., Alaghehbandan, R., et al. (2018) Papillary Renal Cell Carcinoma with Cytologic and Molecular Genetic Features Overlapping with Renal Oncocytoma: Analysis of 10 Cases. Annals of Diagnostic Pathology, 35, 1-6. [Google Scholar] [CrossRef] [PubMed]
[8] Kim, S.S., Cho, Y.M., Kim, G.H., et al. (2020) Recurrent KRAS Mutations Identified in Papillary Renal Neoplasm with Reverse Polarity—A Comparative Study with Papillary Renal Cell Carcinoma. Modern Pathology, 33, 690-699. [Google Scholar] [CrossRef] [PubMed]
[9] He, H., Xu, C., Cheng, Z., et al. (2019) Drug Combinatorial Therapies for the Treatment of KRAS Mutated Lung Cancers. Current Topics in Medicinal Chemistry, 19, 2128-2142. [Google Scholar] [CrossRef] [PubMed]
[10] Al-Obaidy, K.I., Eble, J.N., Cheng, L., et al. (2019) Papillary Renal Neoplasm with Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study. The American Journal of Surgical Pathology, 43, 1099-1111. [Google Scholar] [CrossRef
[11] Trpkov, K., Hes, O., Williamson, S.R., et al. (2021) New Developments in Existing WHO Entities and Evolving Molecular Concepts: The Genitourinary Pathology Society (GUPS) Update on Renal Neoplasia. Modern Pathology, 34, 1392-1424. [Google Scholar] [CrossRef] [PubMed]
[12] 王彦, 种道臣, 信方杰, 等. 肾脏杂合性嗜酸细胞/嫌色细胞肿瘤的临床病理学特征[J]. 中华病理学杂志, 2021, 50(2): 97-102.
[13] Ruiz-Cordero, R., Rao, P., Li, L.R., et al. (2019) Hybrid Oncocytic/Chromophobe Renal Tumors Are Molecularly Distinct from Oncocytoma and Chromophobe Renal Cell Carcinoma. Modern Pathology, 32, 1698-1707. [Google Scholar] [CrossRef] [PubMed]
[14] Idoate, M.A., Trigo, I., Saenz De Zaitigui, J., et al. (2021) Morphological and Molecular Study of Hybrid Oncocytic/Chromophobe Tumor of the Kidney Associated with Sporadic Renal Oncocytosis and Chronic B-Cell Lymphocytic Leukemia: The Possible Contribution of Lymphoma to Renal Oncocytosis. Pathobiology, 88, 313-322. [Google Scholar] [CrossRef] [PubMed]
[15] Trpkov, K. and Hes, O. (2019) New and Emerging Renal Entities: A Perspective Post WHO 2016 Classification. Histopathology, 74, 31-59. [Google Scholar] [CrossRef] [PubMed]
[16] Trpkov, K., Williamson, S.R., Gao, Y., et al. (2019) Low-Grade Oncocytic Tumour of Kidney (CD117-Negative, Cytokeratin 7-Positive): A Distinct Entity? Histopathology, 75, 174-184. [Google Scholar] [CrossRef] [PubMed]
[17] Kravtsov, O., Gupta, S., Cheville, J.C., et al. (2021) Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a Single Institutional Experience with Clinicopathological and Molecular Characteristics. Human Pathology, 114, 9-18. [Google Scholar] [CrossRef] [PubMed]
[18] Webster, B.R., Rompre-Brodeur, A., Daneshvar, M., et al. (2021) Kidney Cancer: From Genes to Therapy. Current Problems in Cancer, 45, Article ID: 100773. [Google Scholar] [CrossRef] [PubMed]
[19] Linehan, W.M., Schmidt, L.S., Crooks, D.R., et al. (2019) The Metabolic Basis of Kidney Cancer. Cancer Discovery, 9, 1006-1021. [Google Scholar] [CrossRef
[20] Yang, B., Duan, H.Q., Cao, W.F., et al. (2019) Xp11 Translocation Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma with TFE3 Strong Positive Immunostaining: Morphology, Immunohistochemistry, and FISH Analysis. Modern Pathology, 32, 1521-1535. [Google Scholar] [CrossRef] [PubMed]
[21] Pei, J.M., Cooper, H., Flieder, D.B., et al. (2019) NEAT1-TFE3 and KAT6A-TFE3 Renal Cell Carcinomas, New Members of MiT Family Translocation Renal Cell Carcinoma. Modern Pathology, 32, 710-716. [Google Scholar] [CrossRef] [PubMed]
[22] Caliò, A., Brunelli, M., Segala, D., et al. (2020) Comprehensive Analysis of 34 MiT Family Translocation Renal Cell Carcinomas and Review of the Literature: Investigating Prognostic Markers and Therapy Targets. Pathology, 52, 297-309. [Google Scholar] [CrossRef] [PubMed]
[23] Harada, S., Caliò, A., Janowski, K.M., et al. (2021) Diagnostic Utility of One-Stop Fusion Gene Panel to Detect TFE3/TFEB Gene Rearrangement and Amplification in Renal Cell Carcinomas. Modern Pathology, 34, 2055-2063. [Google Scholar] [CrossRef] [PubMed]
[24] Zhan, H.-Q., Qin, R., Li, Y.-L., et al. (2021) TFEB Promotes BCL-2 Expression by Upregulating Its Promoter Activity in the T(6;11) Translocation Renal Cell Carcinomas. American Journal of Translational Research, 13, 8804-8818.
[25] Zyla, R.E. and Hodgson, A. (2021) Gene of the Month: FH. Journal of Clinical Pathology, 74, 615-619. [Google Scholar] [CrossRef] [PubMed]
[26] Crooks, D.R., Maio, N., Lang, M., et al. (2021) Mitochondrial DNA Alterations Underlie an Irreversible Shift to Aerobic Glycolysis in Fumarate Hydratase-Deficient Renal Cancer. Science Signaling, 14, eabc4436. [Google Scholar] [CrossRef] [PubMed]
[27] Lau, H.D., Chan, E., Fan, A.C., et al. (2020) A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-Deficient Renal Cell Carcinoma in 32 Patients. The American Journal of Surgical Pathology, 44, 98-110. [Google Scholar] [CrossRef
[28] Gleeson, J.P., Nikolovski, I., Dinatale, R., et al. (2021) Comprehensive Molecular Characterization and Response to Therapy in Fumarate Hydratase-Deficient Renal Cell Carcinoma. Clinical Cancer Research, 27, 2910-2919. [Google Scholar] [CrossRef
[29] Szymanski, M., Rusetska, N., Jancewicz, I., et al. (2021) Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1, 6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report. Oncologist, 26, E1652-E1655. [Google Scholar] [CrossRef] [PubMed]
[30] Sturrock, B.R.H., Macnamara, E.F., McGuire, P., et al. (2021) Progressive Cerebellar Atrophy in a Patient with Complex II and III Deficiency and a Novel Deleterious Variant in SDHA: A Counseling Conundrum. Molecular Genetics & Genomic Medicine, 9, E1692. [Google Scholar] [CrossRef] [PubMed]
[31] Tsai, T.-H. and Lee, W.-Y. (2019) Succinate Dehydrogenase-Deficient Renal Cell Carcinoma. Archives of Pathology & Laboratory Medicine, 143, 643-647. [Google Scholar] [CrossRef
[32] Trpkov, K. and Siadat, F. (2019) Immunohistochemical Screening for the Diagnosis of Succinate Dehydrogenase-Deficient Renal Cell Carcinoma and Fumarate Hydratase-Deficient Renal Cell Carcinoma. Annals of Translational Medicine, 7, S324. [Google Scholar] [CrossRef] [PubMed]
[33] Varchetta, V., Campanella, C., Rossi, M., et al. (2021) Identification of Anaplastic Lymphoma Kinase Fusion in Clear Cell Renal Carcinoma (ALK-TRCC): A Precision Oncology Medicine Case Report. Recenti Progressi in Medicina, 112, 14e-15e.
[34] Siadat, F. and Trpkov, K. (2020) ESC, ALK, HOT and LOT: Three Letter Acronyms of Emerging Renal Entities Knocking on the Door of the WHO Classification. Cancers (Basel), 12, Article No. 168. [Google Scholar] [CrossRef] [PubMed]
[35] Kuroda, N., Trpkov, K., Gao, Y., et al. (2020) ALK Rearranged Renal Cell Carcinoma (ALK-RCC): A Multi-Institutional Study of Twelve Cases with Identification of Novel Partner Genes CLIP1, KIF5B and KIAA1217. Modern Pathology, 33, 2564-2579. [Google Scholar] [CrossRef] [PubMed]
[36] 周露婷, 杨晓群, 许建昆, 等. 嗜酸性实性囊性肾细胞癌7例临床及分子病理特征分析[J]. 临床与实验病理学杂志, 2020, 36(12): 1407-1411.
[37] Hes, O. and Trpkov, K. (2022) Do We Need an Updated Classification of Oncocytic Renal Tumors? Emergence of Low-Grade Oncocytic Tumor (LOT) and Eosinophilic Vacuolated Tumor (EVT) as Novel Renal Entities. Modern Pathology, 35, 1140-1150. [Google Scholar] [CrossRef] [PubMed]
[38] Kapur, P., Gao, M., Zhong, H., et al. (2021) Eosinophilic Vacuolated Tumor of the Kidney: A Review of Evolving Concepts in This Novel Subtype with Additional Insights from a Case with MTOR Mutation and Concomitant Chromosome 1 Loss. Advances in Anatomic Pathology, 28, 251-257. [Google Scholar] [CrossRef
[39] Farcaş, M., Gatalica, Z., Trpkov, K., et al. (2022) Eosinophilic Vacuolated Tumor (EVT) of Kidney Demonstrates Sporadic TSC/MTOR Mutations: Next-Generation Sequencing Multi-Institutional Study of 19 Cases. Modern Pathology, 35, 344-351. [Google Scholar] [CrossRef] [PubMed]