活性氧在皮肤衰老中的作用
The Role of Reactive Oxygen Species in Skin Aging
DOI: 10.12677/acm.2024.1441153, PDF,  被引量   
作者: 陈柳廷, 刘晏伊*：重庆医科大学附属口腔医院，口腔疾病与生物医学重庆市重点实验室，重庆市高校市级口腔生物医学工程重点实验室，重庆
关键词: 皮肤衰老；成纤维细胞；ROS；Skin Aging； Fibroblasts； ROS
摘要: 皮肤作为人体最大的器官，能够直观地反映机体整体的衰老水平。皮肤衰老可分为内源性衰老和外源性衰老，其细胞水平的主要表现是真皮层内成纤维细胞的老化，而其中ROS发挥着关键作用。ROS引起细胞老化的主要机制包括DNA损伤、线粒体氧化损伤、促炎细胞因子水平升高以及ECM的降解。在本综述中，将重点探讨皮肤衰老的特征、ROS的生成以及ROS导致皮肤老化的详细机制。
Abstract: As the body’s largest organ, the skin provides a visual reflection of the overall aging status of the organism. Skin aging can be categorized into intrinsic aging and extrinsic aging, with the primary cellular manifestation occurring in the aging of dermal fibroblasts. In this process, ROS play a crucial role. The major mechanisms through which ROS induces cellular aging include DNA damage, mitochondrial oxidative stress, elevated levels of pro-inflammatory cytokines, and degradation of the ECM. This review focuses on elucidating the characteristics of skin aging, the generation of ROS, and the detailed mechanisms by which ROS contributes to skin aging.
文章引用：陈柳廷, 刘晏伊. 活性氧在皮肤衰老中的作用[J]. 临床医学进展, 2024, 14(4): 1258-1262. https://doi.org/10.12677/acm.2024.1441153

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