颈动脉支架植入术后再狭窄的研究进展
Research Progress on Restenosis after Carotid Artery Stent Implantation
DOI: 10.12677/acm.2024.1441326, PDF,   
作者: 孙 慧:宁夏医科大学临床医学院,宁夏 银川;成 江*:宁夏医科大学总医院心脑血管病医院神经内科,宁夏 银川
关键词: 颈动脉支架植入术支架内再狭窄影响因素影像学检测再狭窄的治疗Carotid Artery Stent Implantation In Stent Restenosis Influencing Factors Imaging Detection Treatment of Restenosis
摘要: 血运重建是颈动脉狭窄患者预防缺血性卒中的有效策略。颈动脉支架植入术是颈动脉内膜切除术的一种安全替代方法,尤其对于手术高危患者。然而,支架内再狭窄增加了复发性缺血性卒中的风险,限制了介入治疗的益处,并对患者构成了显著威胁。颈部血管超声、CT血管造影、数字减影血管造影可用于检测支架植入术后再狭窄,各有优缺点。再狭窄患者需要再干预治疗时,可提供不同的治疗方案,如球囊成形术、重复支架植入等,但最佳治疗策略尚未明确。因此,研究颈动脉支架植入术术后再狭窄,对提高颈动脉支架植入术的长期疗效至关重要。
Abstract: Revascularization is an effective strategy for preventing ischemic stroke in patients with carotid artery stenosis. Carotid artery stent implantation is a safe alternative to carotid endarterectomy, especially for high-risk patients undergoing surgery. However, stent restenosis increases the risk of recurrent ischemic stroke, limits the benefits of interventional treatment, and poses a significant threat to patients. Cervical vascular ultrasound, CT angiography, and digital subtraction angiography can be used to detect restenosis after stent implantation, each with its own advantages and disadvantages. When patients with restenosis need further intervention treatment, different treatment options can be provided, such as balloon angioplasty, repeated stent implantation, etc., but the optimal treatment strategy is not yet clear. Therefore, studying restenosis after carotid artery stent implantation is crucial for improving the long-term efficacy of carotid artery stent implantation.
文章引用:孙慧, 成江. 颈动脉支架植入术后再狭窄的研究进展[J]. 临床医学进展, 2024, 14(4): 2540-2548. https://doi.org/10.12677/acm.2024.1441326

参考文献

[1] 《中国脑卒中防治报告2021》概要[J]. 中国脑血管病杂志, 2023, 20(11): 783-793.
[2] 中华医学会外科学分会血管外科学组. 颈动脉狭窄诊治指南[J]. 中华血管外科杂志, 2017, 2(2): 78-84.
[3] Bonati, L.H., Jansen, O., De Borst, G.J., et al. (2022) Management of Atherosclerotic Extracranial Carotid Artery Stenosis. The Lancet Neurology, 21, 273-283. [Google Scholar] [CrossRef
[4] Brott, T.G., Howard, G., Roubin, G.S., et al. (2016) Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis. The New England Journal of Medicine, 374, 1021-1031. [Google Scholar] [CrossRef
[5] Bonati, L., Dobson, J., Featherstone, R., et al. (2015) Long-Term Outcomes after Stenting versus Endarterectomy for Treatment of Symptomatic Carotid Stenosis: The International Carotid Stenting Study (ICSS) Randomised Trial. Lancet, 385, 529-538. [Google Scholar] [CrossRef
[6] Lal, B., Beach, K., Roubin, G., et al. (2012) Restenosis after Carotid Artery Stenting and Endarterectomy: A Secondary Analysis of CREST, a Randomised Controlled Trial. The Lancet Neurology, 11, 755-763. [Google Scholar] [CrossRef
[7] Hunter, G.C. (1997) The Clinical and Pathological Spectrum of Recurrent Carotid Stenosis. American Journal of Surgery, 174, 583-588. [Google Scholar] [CrossRef
[8] De Borst, G. and Moll, F. (2012) Biology and Treatment of Recurrent Carotid Stenosis. The Journal of Cardiovascular Surgery, 53, 27-34.
[9] Bonati, L., Gregson, J., Dobson, J., et al. (2018) Restenosis and Risk of Stroke after Stenting or Endarterectomy for Symptomatic Carotid Stenosis in the International Carotid Stenting Study (ICSS): Secondary Analysis of a Randomised Trial. The Lancet Neurology, 17, 587-596. [Google Scholar] [CrossRef
[10] Bajeu, I.I., Niculescu A.G., Scafa-Udriste, A., et al. (2024) Intrastent Restenosis: A Comprehensive Review. International Journal of Molecular Sciences, 25, Article 1715. [Google Scholar] [CrossRef] [PubMed]
[11] Stilo, F., Montelione, N., Calandrelli, R., et al. (2020) The Management of Carotid Restenosis: A Comprehensive Review. Annals of Translational Medicine, 8, Article 1272. [Google Scholar] [CrossRef] [PubMed]
[12] Willfort-Ehringer, A., Ahmadi, R., Gessl, A., et al. (2004) Neointimal Proliferation within Carotid Stents Is More Pronounced in Diabetic Patients with Initial Poor Glycaemic State. Diabetologia, 47, 400-406. [Google Scholar] [CrossRef] [PubMed]
[13] Ma, X., Jiang, C., Li, Y., et al. (2017) Inhibition Effect of Tacrolimus and Platelet-Derived Growth Factor-BB on Restenosis after Vascular Intimal Injury. Biomedicine & Pharmacotherapy, 93, 180-189. [Google Scholar] [CrossRef] [PubMed]
[14] Goel, S.A., Guo, L.W., Liu, B. and Kent, K.C. (2012) Mechanisms of Post-Intervention Arterial Remodelling. Cardiovascular Research, 96, 363-371. [Google Scholar] [CrossRef] [PubMed]
[15] Aoki, J. AND Tanabe, K. (2021) Mechanisms of Drug-Eluting Stent Restenosis. Cardiovascular Intervention and Therapeutics, 36, 23-29. [Google Scholar] [CrossRef] [PubMed]
[16] Byrne, R.A., Joner, M. and Kastrati, A. (2015) Stent Thrombosis and Restenosis: What Have We Learned and Where Are We Going? The Andreas Grüntzig Lecture ESC 2014. European Heart Journal, 36, 3320-3331. [Google Scholar] [CrossRef] [PubMed]
[17] Forte, A., Rinaldi, B., Berrino, L., et al. (2014) Novel Potential Targets for Prevention of Arterial Restenosis: Insights from the Pre-Clinical Research. Clinical Science, 127, 615-634. [Google Scholar] [CrossRef
[18] Eckstein, H.H., Ringleb, P., Allenberg, J.R., et al. (2008) Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) Study to Treat Symptomatic Stenoses at 2 Years: A Multinational, Prospective, Randomised Trial. The Lancet Neurology, 7, 893-902. [Google Scholar] [CrossRef
[19] Bonati, L.H., Ederle, J., McCabe, D.J., et al. (2009) Long-Term Risk of Carotid Restenosis in Patients Randomly Assigned to Endovascular Treatment or Endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): Long-Term Follow-Up of a Randomised Trial. The Lancet Neurology, 8, 908-917. [Google Scholar] [CrossRef
[20] Arquizan, C., Trinquart, L., Touboul, P.J., et al. (2011) Restenosis Is More Frequent after Carotid Stenting than after Endarterectomy: The EVA-3S Study. Stroke, 42, 1015-1020. [Google Scholar] [CrossRef
[21] Mas, J.L., Arquizan, C., Calvet, D., et al. (2014) Long-Term Follow-Up Study of Endarterectomy versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis Trial. Stroke, 45, 2750-2756. [Google Scholar] [CrossRef
[22] Aleksic, N., Tanaskovic, S., Radak, S., et al. (2011) Color Duplex Sonography in the Detection of Internal Carotid Artery Restenosis after Carotid Endarterectomy: Comparison with Computed Tomographic Angiography. Journal of Ultrasound in Medicine, 30, 1677-1682. [Google Scholar] [CrossRef] [PubMed]
[23] Lal, B.K., Hobson, R.W., Goldstein, J., et al. (2004) Carotid Artery Stenting: Is There a Need to Revise Ultrasound Velocity Criteria? Journal of Vascular Surgery, 39, 58-66. [Google Scholar] [CrossRef] [PubMed]
[24] Setacci, C., Chisci, E., Setacci, F., et al. (2008) Grading Carotid Intrastent Restenosis: A 6-Year Follow-Up Study. Stroke, 39, 1189-1196. [Google Scholar] [CrossRef
[25] Lal, B.K., Hobson, R.W., Tofighi, B., et al. (2008) Duplex Ultrasound Velocity Criteria for the Stented Carotid Artery. Journal of Vascular Surgery, 47, 63-73. [Google Scholar] [CrossRef] [PubMed]
[26] Bosch, F.T., Hendrikse, J., Davagnanam, I., et al. (2017) Optimal Cut-Off Criteria for Duplex Ultrasound Compared with Computed Tomography Angiography for the Diagnosis of Restenosis in Stented Carotid Arteries in the International Carotid Stenting Study. European Stroke Journal, 2, 37-45. [Google Scholar] [CrossRef] [PubMed]
[27] Lettau, M., Kotter, E., Bendszus, M., et al. (2014) Carotid Artery Stents on CT Angiography: In Vitro Comparison of Different Stent Designs and Sizes Using 16-, 64-and 320-Row CT Scanners. Journal of Neuroradiology, 41, 259-268. [Google Scholar] [CrossRef] [PubMed]
[28] Mousa, A.Y., AbuRahma, A.F., Bozzay, J., et al. (2015) Long-Term Comparative Outcomes of Carotid Artery Stenting Following Previous Carotid Endarterectomy vs De Novo Lesions. Journal of Endovascular Therapy, 22, 449-456. [Google Scholar] [CrossRef] [PubMed]
[29] Takao, N., Hagiwara, Y., Shimizu, T., et al. (2020) Preprocedural Carotid Plaque Echolucency as a Predictor of In-Stent Intimal Restenosis after Carotid Artery Stenting. Journal of Stroke and Cerebrovascular Diseases, 29, Article ID: 105339. [Google Scholar] [CrossRef] [PubMed]
[30] Hagiwara, Y., Takao, N., Takada, T., et al. (2019) Contrast-Enhanced Carotid Ultrasonography and MRI Plaque Imaging to Identify Patients Developing In-Stent Intimal Hyperplasia after Carotid Artery Stenting. Medical Ultrasonography, 21, 170-174. [Google Scholar] [CrossRef] [PubMed]
[31] 胡利刚, 唐景峰, 张洁, 等. 颈动脉重度狭窄患者斑块最大厚度对颈动脉支架成形术后再狭窄预测价值研究[J]. 中国实用神经疾病杂志, 2020, 23(14): 1241-1245.
[32] Shankar, J.J., Zhang, J., Dos Santos, M., et al. (2012) Factors Affecting Long-Term Restenosis after Carotid Stenting for Carotid Atherosclerotic Disease. Neuroradiology, 54, 1347-1353. [Google Scholar] [CrossRef] [PubMed]
[33] Grafmuller, L.E., Lehane, D.J., Dohring, C.L., et al. (2023) Impact of Calcified Plaque Volume on Technical and 3-Year Outcomes after Transcarotid Artery Revascularization. Journal of Vascular Surgery, 78, 150-157. [Google Scholar] [CrossRef] [PubMed]
[34] Zapata-Arriaza, E., Moniche, F., González, A., et al. (2016) Predictors of Restenosis Following Carotid Angioplasty and Stenting. Stroke, 47, 2144-2147. [Google Scholar] [CrossRef
[35] Megaly, M., Alani, F., Cheng, C.I., et al. (2021) Risk Factors for the Development of Carotid Artery In-Stent Restenosis: Multivariable Analysis. Cardiovascular Revascularization Medicine, 24, 65-69. [Google Scholar] [CrossRef] [PubMed]
[36] Ma, W., Liang, Y., Zhu, J., et al. (2016) Relationship of Paraoxonase-1 Q192R Genotypes and In-Stent Restenosis and Re-Stenting in Chinese Patients after Coronary Stenting. Atherosclerosis, 251, 305-310. [Google Scholar] [CrossRef] [PubMed]
[37] Mazighi, M., Saint Maurice, J.P., Bresson, D., et al. (2010) Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis. American Journal of Neuroradiology, 31, 496-497. [Google Scholar] [CrossRef
[38] Mihály, Z., Vértes, M., Entz, L. and Dósa, E. (2021) Treatment and Predictors of Recurrent Internal Carotid Artery In-Stent Restenosis. Vascular and Endovascular Surgery, 55, 374-381. [Google Scholar] [CrossRef] [PubMed]
[39] Dai, Z., Li, R., Zhao, N., et al. (2019) Neutrophil to Lymphocyte Ratio as a Predictor of Restenosis after Angioplasty and Stenting for Asymptomatic Carotid Stenosis. Angiology, 70, 160-165. [Google Scholar] [CrossRef] [PubMed]
[40] Bao, X., Zhou, G., Xu, W., et al. (2020) Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for the Diagnosis and Prognosis in Patients with Restenosis Following CAS. Biomarkers in Medicine, 14, 271-282. [Google Scholar] [CrossRef] [PubMed]
[41] Shen, H., Dai, Z., Wang, M., et al. (2019) Preprocedural Neutrophil to Albumin Ratio Predicts In-Stent Restenosis Following Carotid Angioplasty and Stenting. Journal of Stroke and Cerebrovascular Diseases, 28, 2442-2447. [Google Scholar] [CrossRef] [PubMed]
[42] Dai, Z., Gao, J., Li, S., et al. (2018) Mean Platelet Volume as a Predictor for Restenosis after Carotid Angioplasty and Stenting. Stroke, 49, 872-876. [Google Scholar] [CrossRef
[43] Miura, Y., Kanamaru, H., Yasuda, R., et al. (2021) Nonfasting Triglyceride as an Independent Predictor of Carotid Restenosis after Carotid Endarterectomy or Carotid Artery Stenting. World Neurosurgery, 156, e415-e425. [Google Scholar] [CrossRef] [PubMed]
[44] Topakian, R., Sonnberger, M., Nussbaumer, K., et al. (2008) Postprocedural High-Density Lipoprotein Cholesterol Predicts Carotid Stent Patency at 1 Year. European Journal of Neurology, 15, 179-184. [Google Scholar] [CrossRef] [PubMed]
[45] Qu, X.P., Wu, Y.L., Shen, L.L., et al. (2024) Utility of the Triglyceride-Glucose Index for Predicting Restenosis Following Revascularization Surgery for Extracranial Carotid Artery Stenosis: A Retrospective Cohort Study. Journal of Stroke and Cerebrovascular Diseases, 33, Article ID: 107563. [Google Scholar] [CrossRef] [PubMed]
[46] Hu, J., Hu, N., Hu, T., et al. (2023) Associations between Preprocedural Carotid Artery Perivascular Fat Density and Early In-Stent Restenosis after Carotid Artery Stenting. Heliyon, 9, e16220. [Google Scholar] [CrossRef] [PubMed]
[47] Kumar, R., Batchelder, A., Saratzis, A., et al. (2017) Restenosis after Carotid Interventions and Its Relationship with Recurrent Ipsilateral Stroke: A Systematic Review and Meta-Analysis. European Journal of Vascular and Endovascular Surgery, 53, 766-775. [Google Scholar] [CrossRef] [PubMed]
[48] Naylor, R., Rantner, B., Ancetti, S., et al. (2023) Editor’s Choice—European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease. European Journal of Vascular and Endovascular Surgery, 65, 7-111. [Google Scholar] [CrossRef] [PubMed]
[49] Friedland, S.N., Eisenberg, M.J. and Shimony, A. (2012) Meta-Analysis of Randomized Controlled Trials on Effect of Cilostazol on Restenosis Rates and Outcomes after Percutaneous Coronary Intervention. American Journal of Cardiology, 109, 1397-1404. [Google Scholar] [CrossRef] [PubMed]
[50] Soga, Y., Iida, O., Hirano, K., et al. (2012) Restenosis after Stent Implantation for Superficial Femoral Artery Disease in Patients Treated with Cilostazol. Catheterization and Cardiovascular Interventions, 79, 541-548. [Google Scholar] [CrossRef] [PubMed]
[51] Miyazaki, Y., Mori, T., Iwata, T., et al. (2016) Continuous Daily Use of Cilostazol Prevents In-Stent Restenosis Following Carotid Artery Stenting: Serial Angiographic Investigation of 229 Lesions. Journal of Neurointerventional Surgery, 8, 471-475. [Google Scholar] [CrossRef] [PubMed]
[52] 刘建峰, 侯凯, 张峰, 等. 他汀类药物对颈内动脉狭窄支架成形术后支架内再狭窄的影响[J]. 脑与神经疾病杂志, 2014, 22(1): 43-46.
[53] Jing, L., Wang, W., Zhang, S., et al. (2015) Targeted Inhibitory Effect of Lenti-SM22α-P27-EGFP Recombinant Lentiviral Vectors on Proliferation of Vascular Smooth Muscle Cells without Compromising Re-Endothelialization in a Rat Carotid Artery Balloon Injury Model. PLOS ONE, 10, e0118826. [Google Scholar] [CrossRef] [PubMed]