氢吗啡酮应用于骨科患者术后镇痛的研究进展

Research Progress in the Application of Hydromorphone to Postoperative Analgesia in Orthopaedic Patients

摘要: 镇痛是骨科患者术后康复中不可或缺的一环，不仅仅是减轻疼痛的关键，也是术后加速康复(ERAS)的重要环节。目前，在骨科手术术后有多种镇痛模式可供选择，包括连续硬膜外镇痛、连续外周神经阻滞镇痛以及患者自控镇痛等。镇痛药物类别丰富，应用最广的当属阿片类药物，氢吗啡酮作为吗啡的半合成衍生物，相比吗啡，能更快缓解疼痛，镇痛强度更高，副作用更少等特点。在骨科患者术后逐渐显示出它独特的镇痛优势，本文旨在综述氢吗啡酮在不同类型镇痛模式下的有效性，并促进其应用于骨科患者镇痛，加速骨科患者术后康复，提高患者镇痛满意度。

Abstract: Analgesia is an indispensable part of postoperative recovery of orthopaedic patients, which is not only the key to reduce pain, but also an important part of enhance recovery after surgery (ERAS). At present, there are a variety of analgesia modes to choose after orthopedic surgery, including continuous epidural analgesia, continuous peripheral nerve block analgesia, and patient-controlled analgesia. There are various types of analgesic drugs, and the most widely used ones are opioids. Hydromorphone, as a semi-synthetic derivative of morphine, has the characteristics of faster onset, stronger analgesic effject and fewer adverse reactions. It gradually shows its unique analgesic advantages in orthopaedic patients after surgery. This paper aims to review the effectiveness of hydromorphone in different types of analgesic modes, and promote its application in orthopaedic patients, enhance postoperative recovery of orthopaedic patients, and improve patients’ satisfaction with analgesia.