朝藿定A药理学研究进展
Study Advances in Pharmacology of Epimedin A
DOI: 10.12677/acm.2024.14112907, PDF,    科研立项经费支持
作者: 王 蓉*, 冯 芸, 乔 雯:延安大学医学院内科学,陕西 延安;高宇勤#:西安市第九医院心内科,陕西 西安
关键词: 淫羊藿朝藿定A药理学Epimedium Epimedin A Pharmacology
摘要: 淫羊藿为我国传统常用中药,朝藿定A是淫羊藿的主要成分之一。目前研究显示具有抗骨质疏松、抗炎、抗氧化、抗菌、抗阿尔茨海默病、神经保护等药理活性。本文结合文献对朝藿定A的药理学活性作用进行综述,为该化合物的基础研究及临床应用提供借鉴。
Abstract: Epimedium is a traditional Chinese medicine commonly used in China, and Epimedin A is one of the main components of Epimedium. Current studies have shown that it has pharmacological activities such as anti-osteoporosis, anti-inflammatory, antioxidant, antibacterial, anti-Alzheimer’s and neuroprotection. This article reviews the pharmacological activity of Epimedin A based on the literature, and provides a reference for the basic research and clinical application of Epimedin A.
文章引用:王蓉, 冯芸, 乔雯, 高宇勤. 朝藿定A药理学研究进展[J]. 临床医学进展, 2024, 14(11): 499-504. https://doi.org/10.12677/acm.2024.14112907

参考文献

[1] 李莉, 王嘉瑞, 王晶, 等. 淫羊藿的主要化学成分、药理作用研究进展及质量标志物的预测分析[J]. 中华中医药学刊, 2023, 41(11): 143-151.
[2] 史阔豪, 张光财, 武康雄, 等. 4种淫羊藿黄酮苷类主要成分体外药理活性比较[J]. 陕西科技大学学报, 2021, 39(2): 56-61.
[3] 贾晓斌, 钱浅, 孙娥, 等. 淫羊藿黄酮药代动力学研究进展[J]. 中成药, 2012, 34(11): 2193-2197.
[4] Liu, Y., Bi, Y., Chai, L., Song, L., Huang, J., Wang, Q., et al. (2021) Development of Epimedin a Complex Drugs for Treating the Osteoporosis. Journal of Materials Science: Materials in Medicine, 32, Article No. 17. [Google Scholar] [CrossRef] [PubMed]
[5] Xi, H., Ma, H., Yang, F., Gao, Y., Zhou, J., Wang, Y., et al. (2018) Total Flavonoid Extract of Epimedium Herb Increases the Peak Bone Mass of Young Rats Involving Enhanced Activation of the AC10/cAMP/PKA/CREB Pathway. Journal of Ethnopharmacology, 223, 76-87. [Google Scholar] [CrossRef] [PubMed]
[6] Wang, Y., Pu, Y., Shi, G., et al. (2019) Pulsed Electromagnetic Fields Promote Bone Formation by Activating the sAC-cAMP-PKA-CREB Signaling Pathway. Journal of Cellular Physiology, 234, 2807-2821.
[7] Grässel, S. and Muschter, D. (2017) Peripheral Nerve Fibers and Their Neurotransmitters in Osteoarthritis Pathology. International Journal of Molecular Sciences, 18, Article No. 931. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, H., Xiong, Y., Wang, H., Yang, L., Wang, C., Liu, X., et al. (2018) Effects of Water Extract from Epimedium on Neuropeptide Signaling in an Ovariectomized Osteoporosis Rat Model. Journal of Ethnopharmacology, 221, 126-136. [Google Scholar] [CrossRef] [PubMed]
[9] 刘颖, 柴丽娟, 黄菊阳, 等. 朝藿定A对破骨细胞及骨质疏松雄性小鼠的作用[J]. 中国兽医学报, 2021, 41(7): 1359-1364.
[10] 刘颖, 柴丽娟, 黄菊阳, 等. 朝藿定A对原代骨髓间充质干细胞向成骨细胞分化的作用[J]. 中国兽医学报, 2021, 41(5): 980-984, 991.
[11] Balaha, M.F., Ahmed, N.J., Almalki, Z.S., Alahmari, A.K., Alshehri, A.M., Soliman, G.A., et al. (2022) Epimedin a Ameliorates DNFB-Induced Allergic Contact Dermatitis in Mice: Role of NF-κB/NLRP3-Driven Pyroptosis, Nrf2/HO-1 Pathway, and Inflammation Modulation. Life Sciences, 302, Article ID: 120653. [Google Scholar] [CrossRef] [PubMed]
[12] Zhao, J., Liu, H., Hong, Z., et al. (2023) Tanshinone I Specifically Suppresses NLRP3 Inflammasome Activation by Disrupting the Association of NLRP3 and ASC. Molecular Medicine, 29, Article No. 84.
[13] Li, J., Chen, W., Wang, Y. and Yin, H. (2021) An LC‐MS/MS Method for Simultaneous Quantification of 11 Components of Xian‐Xiong‐Gu‐Kang in the Plasma of Osteoarthritic Rats and Pharmacokinetic Analysis. Journal of Separation Science, 44, 3386-3397. [Google Scholar] [CrossRef] [PubMed]
[14] Ziadlou, R., Barbero, A., Stoddart, M.J., Wirth, M., Li, Z., Martin, I., et al. (2019) Regulation of Inflammatory Response in Human Osteoarthritic Chondrocytes by Novel Herbal Small Molecules. International Journal of Molecular Sciences, 20, Article No. 5745. [Google Scholar] [CrossRef] [PubMed]
[15] Xia, J., Hu, J., Wang, Z., Cai, E., Ren, S., Wang, Y., et al. (2022) Based on Network Pharmacology and Molecular Docking to Explore the Protective Effect of Epimedii Folium Extract on Cisplatin-Induced Intestinal Injury in Mice. Frontiers in Pharmacology, 13, Article ID: 1040504. [Google Scholar] [CrossRef] [PubMed]
[16] Li, L., Chen, B., An, T., Zhang, H., Xia, B., Li, R., et al. (2021) Bazibushen Alleviates Altered Testicular Morphology and Spermatogenesis and Modulates Sirt6/p53 and Sirt6/NF-κB Pathways in Aging Mice Induced by D-Galactose and NaNO2. Journal of Ethnopharmacology, 271, Article ID: 113810. [Google Scholar] [CrossRef] [PubMed]
[17] Zhao, H., Sun, J., Fan, M., Fan, L., Zhou, L., Li, Z., et al. (2008) Analysis of Phenolic Compounds in Epimedium Plants Using Liquid Chromatography Coupled with Electrospray Ionization Mass Spectrometry. Journal of Chromatography A, 1190, 157-181. [Google Scholar] [CrossRef] [PubMed]
[18] Zhang, J., Zhao, Q., Qin, Y., Si, W., Zhang, H. and Zhang, J. (2023) The Effect of Epimedium Isopentenyl Flavonoids on the Broiler Gut Health Using Microbiomic and Metabolomic Analyses. International Journal of Molecular Sciences, 24, Article No. 7646. [Google Scholar] [CrossRef] [PubMed]
[19] 宋剑, 王超, 李知遥, 等. 淫羊藿总黄酮抗老年痴呆化学成分研究[J]. 中国现代中药, 2009, 11(8): 23-26.
[20] 叶喜阳, 蔡如玉. 淫羊藿黄酮对药物卵巢去势引起的更年期综合征的临床疗效及安全性[J]. 中国临床药理学杂志, 2015, 31(22): 2217-2219.
[21] 李英, 王俨如, 张小强, 吴云, 丁岗. 淫羊藿中不同部位及单体化合物对Aβ_(25-35)诱导的SH-SY5Y细胞损伤的影响[J]. 中草药, 2017, 48(24): 5206-5210.
[22] Zhong, R., Chen, Y., Ling, J., Xia, Z., Zhan, Y., Sun, E., et al. (2019) The Toxicity and Metabolism Properties of Herba epimedii Flavonoids on Laval and Adult Zebrafish. Evidence-Based Complementary and Alternative Medicine, 2019, Article ID: 3745051. [Google Scholar] [CrossRef] [PubMed]