阴道微生态、HR-HPV、白介素-6与宫颈病变相关性的研究进展
Research Progress on the Correlation between Vaginal Microbiota, HR-HPV, Interleukin-6 and Cervical Lesions
DOI: 10.12677/jcpm.2024.34195, PDF,   
作者: 兰天宇, 李寅雁*：内蒙古民族大学第二临床医学院，内蒙古 通辽
关键词: 宫颈病变；HR-HPV；阴道微生态；白介素-6；Cervical Lesions； HR-HPV； Vaginal Microbiota； Interleukin-6
摘要: 有许多女性对宫颈病变早期变化不重视，以至于最后发生恶变。选择敏感可靠的检测指标，对于宫颈病变的早诊断、早治疗和改善预后有重要意义。本文通过分析宫颈病变患者中阴道微生态、HR-HPV的检出情况以及炎症因子白介素-6的表达情况，对阴道微生态改变、HR-HPV感染和宫颈病变的关系和相关性，以及炎症因子白介素-6的表达与宫颈病变的关系做一综述。为宫颈癌早期筛查、干预及诊断工作提供科学依据。
Abstract: Many women do not pay attention to the early changes of cervical lesions, resulting in malignant transformation in the end. Choosing sensitive and reliable detection indicators is of great significance for the early diagnosis, treatment, and improvement of prognosis of cervical lesions. This article provides a review of the relationship and correlation between changes in vaginal microbiota, HR-HPV infection, and cervical lesions, as well as the relationship between the expression of inflammatory cytokine interleukin-6 and cervical lesions, by analyzing the detection of vaginal microbiota, HR-HPV, and the expression of inflammatory cytokine interleukin-6 in patients with cervical lesions, in order to provide scientific basis for early screening, intervention, and diagnosis of cervical cancer.
文章引用：兰天宇, 李寅雁. 阴道微生态、HR-HPV、白介素-6与宫颈病变相关性的研究进展[J]. 临床个性化医学, 2024, 3(4): 1377-1383. https://doi.org/10.12677/jcpm.2024.34195

参考文献

[1] Anderson, B.L., Cu-Uvin, S., Raker, C.A., Fitzsimmons, C. and Hillier, S.L. (2011) Subtle Perturbations of Genital Microflora Alter Mucosal Immunity among Low-Risk Pregnant Women. Acta Obstetricia et Gynecologica Scandinavica, 90, 510-515. [Google Scholar] [CrossRef] [PubMed]
[2] Su, X., Liu, P., Zhao, H., Sun, L., Wang, W., Jin, S., et al. (2023) Impact of HR-HPV Infection on Oncological Outcomes in Early Cervical Cancer. Frontiers in Oncology, 13, Article 1264114. [Google Scholar] [CrossRef] [PubMed]
[3] Perkins, R.B., Wentzensen, N., Guido, R.S. and Schiffman, M. (2023) Cervical Cancer Screening: A Review. JAMA, 330, 547-558. [Google Scholar] [CrossRef] [PubMed]
[4] Smola, S. (2017) Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy. Viruses, 9, Article 254. [Google Scholar] [CrossRef] [PubMed]
[5] Moody, C.A. and Laimins, L.A. (2010) Human Papillomavirus Oncoproteins: Pathways to Transformation. Nature Reviews Cancer, 10, 550-560. [Google Scholar] [CrossRef] [PubMed]
[6] Wang, W., Liu, Y., Yang, Y., Ren, J. and Zhou, H. (2023) Changes in Vaginal Microbiome after Focused Ultrasound Treatment of High-Risk Human Papillomavirus Infection-Related Low-Grade Cervical Lesions. BMC Infectious Diseases, 23, Article No. 3. [Google Scholar] [CrossRef] [PubMed]
[7] Zheng, J., Song, J., Yu, C., Wang, F., Wang, P. and Meng, J. (2019) Difference in Vaginal Microecology, Local Immunity and HPV Infection among Childbearing-Age Women with Different Degrees of Cervical Lesions in Inner Mongolia. BMC Women’s Health, 19, Article No. 109. [Google Scholar] [CrossRef] [PubMed]
[8] Ye, J. and Qi, X. (2023) Vaginal Microecology and Its Role in Human Papillomavirus Infection and Human Papillomavirus Associated Cervical Lesions. APMIS, 132, 928-947. [Google Scholar] [CrossRef] [PubMed]
[9] Clarke, M.A., Rodriguez, A.C., Gage, J.C., Herrero, R., Hildesheim, A., Wacholder, S., et al. (2012) A Large, Population-Based Study of Age-Related Associations between Vaginal Ph and Human Papillomavirus Infection. BMC Infectious Diseases, 12, Article No. 33. [Google Scholar] [CrossRef] [PubMed]
[10] 吕熙赢. 常见阴道病原体、阴道微生态、IL-6与宫颈病变相关性的研究[D]: [硕士学位论文]. 大连: 大连医科大学, 2023.
[11] 夏依旦∙罗合曼江, 杜蓉. 不同级别宫颈病变与人乳头瘤病毒感染及阴道微环境的关系研究[J]. 中国全科医学, 2022, 25(23): 2881-2884.
[12] Shen, L., Zhang, W., Yuan, Y., Zhu, W. and Shang, A. (2022) Vaginal Microecological Characteristics of Women in Different Physiological and Pathological Period. Frontiers in Cellular and Infection Microbiology, 12, Article 959793. [Google Scholar] [CrossRef] [PubMed]
[13] Brotman, R.M., Shardell, M.D., Gajer, P., Tracy, J.K., Zenilman, J.M., Ravel, J., et al. (2014) Interplay between the Temporal Dynamics of the Vaginal Microbiota and Human Papillomavirus Detection. Journal of Infectious Diseases, 210, 1723-1733. [Google Scholar] [CrossRef] [PubMed]
[14] Gao, W., Weng, J., Gao, Y. and Chen, X. (2013) Comparison of the Vaginal Microbiota Diversity of Women with and without Human Papillomavirus Infection: A Cross-Sectional Study. BMC Infectious Diseases, 13, Article No. 271. [Google Scholar] [CrossRef] [PubMed]
[15] Xiao, B.B., Liu, Z.H. and Liao, Q.P. (2009) Microecological Investigation of Vaginal Microflora in Women with Varying Degree Gynecologic Symptoms in Clinics. Chinese Journal of Obstetrics and Gynecology, 44, 6-8. (In Chinese)
[16] Golijow, C.D., Abba, M.C., Mourón, S.A., Laguens, R.M., Dulout, F.N. and Smith, J.S. (2005) Chlamydia Trachomatis and Human Papillomavirus Infections in Cervical Disease in Argentine Women. Gynecologic Oncology, 96, 181-186. [Google Scholar] [CrossRef] [PubMed]
[17] Ravel, J., Gajer, P., Abdo, Z., Schneider, G.M., Koenig, S.S.K., McCulle, S.L., et al. (2010) Vaginal Microbiome of Reproductive-Age Women. Proceedings of the National Academy of Sciences of the United States of America, 108, 4680-4687. [Google Scholar] [CrossRef] [PubMed]
[18] Onderdonk, A.B., Delaney, M.L. and Fichorova, R.N. (2016) The Human Microbiome during Bacterial Vaginosis. Clinical Microbiology Reviews, 29, 223-238. [Google Scholar] [CrossRef] [PubMed]
[19] Gillet, E., Meys, J.F., Verstraelen, H., Bosire, C., De Sutter, P., Temmerman, M., et al. (2011) Bacterial Vaginosis Is Associated with Uterine Cervical Human Papillomavirus Infection: A Meta-Analysis. BMC Infectious Diseases, 11, Article No. 10. [Google Scholar] [CrossRef] [PubMed]
[20] Donders, G.G.G., Prenen, H., Verbeke, G. and Reybrouck, R. (2002) Impaired Tolerance for Glucose in Women with Recurrent Vaginal Candidiasis. American Journal of Obstetrics and Gynecology, 187, 989-993. [Google Scholar] [CrossRef] [PubMed]
[21] Donders, G.G.G., Ruban, K., Depuydt, C., Bellen, G., Vanden Broeck, D., Jonckheere, J., et al. (2018) Treatment Attitudes for Belgian Women with Persistent Trichomonas Vaginalis Infection in the Vlarest Study. Clinical Infectious Diseases, 68, 1575-1580. [Google Scholar] [CrossRef] [PubMed]
[22] Engberts, M.K., Vermeulen, C.F.W., Verbruggen, B.S.M., van Haaften, M., Boon, M.E. and Heintz, A.P.M. (2006) Candida and Squamous (pre)neoplasia of Immigrants and Dutch Women as Established in Population-Based Cervical Screening. International Journal of Gynecological Cancer, 16, 1596-1600. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, X., Coleman, H.N., Nagarajan, U., Spencer, H.J. and Nakagawa, M. (2013) Candida Skin Test Reagent as a Novel Adjuvant for a Human Papillomavirus Peptide-Based Therapeutic Vaccine. Vaccine, 31, 5806-5813. [Google Scholar] [CrossRef] [PubMed]
[24] Lukic, A., Canzio, C., Patella, A., et al. (2006) Determination of Cervicovaginal Microorganisms in Women with Abnormal Cervical Cytology: The Role of Ureaplasma Urealyticum. Anticancer Research, 26, 4843-4849.
[25] Biernat-Sudolska, M., Szostek, S., Rojek-Zakrzewska, D., Klimek, M. and Kosz-Vnenchak, M. (2011) Concomitant Infections with Human Papillomavirus and Various Mycoplasma and Ureaplsasma Species in Women with Abnormal Cervical Cytology. Advances in Medical Sciences, 56, 299-303. [Google Scholar] [CrossRef] [PubMed]
[26] Magaña-Contreras, M., Contreras-Paredes, A., Chavez-Blanco, A., Lizano, M., Cruz-Hernandez, Y.D.L. and Cruz-Hernandez, E.D.L. (2015) Prevalence of Sexually Transmitted Pathogens Associated with HPV Infection in Cervical Samples in a Mexican Population. Journal of Medical Virology, 87, 2098-2105. [Google Scholar] [CrossRef] [PubMed]
[27] Castle, P.E. and Giuliano, A.R. (2003) Chapter 4: Genital Tract Infections, Cervical Inflammation, and Antioxidant Nutrients—Assessing Their Roles as Human Papillomavirus Cofactors. JNCI Monographs, 2003, 29-34. [Google Scholar] [CrossRef] [PubMed]
[28] Tanaka, T., Narazaki, M. and Kishimoto, T. (2014) IL-6 in Inflammation, Immunity, and Disease. Cold Spring Harbor Perspectives in Biology, 6, a016295. [Google Scholar] [CrossRef] [PubMed]
[29] Hodge, D.R., Hurt, E.M. and Farrar, W.L. (2005) The Role of IL-6 and STAT3 in Inflammation and Cancer. European Journal of Cancer, 41, 2502-2512. [Google Scholar] [CrossRef] [PubMed]
[30] Wei, L., Kuo, M., Chen, C., Cheng, W., Cheng, S., Hsieh, F., et al. (2001) Interleukin-6 in Cervical Cancer: The Relationship with Vascular Endothelial Growth Factor. Gynecologic Oncology, 82, 49-56. [Google Scholar] [CrossRef] [PubMed]
[31] Song, Z., Lin, Y., Ye, X., Feng, C., Lu, Y., Yang, G., et al. (2016) Expression of IL-1α and IL-6 Is Associated with Progression and Prognosis of Human Cervical Cancer. Medical Science Monitor, 22, 4475-4481. [Google Scholar] [CrossRef] [PubMed]
[32] Jee, S., Shen, S., Chiu, H., Tsai, W. and Kuo, M. (2001) Overexpression of Interleukin-6 in Human Basal Cell Carcinoma Cell Lines Increases Anti-Apoptotic Activity and Tumorigenic Potency. Oncogene, 20, 198-208. [Google Scholar] [CrossRef] [PubMed]
[33] Dell’Oste, V., Azzimonti, B., Mondini, M., De Andrea, M., Borgogna, C., Mesturini, R., et al. (2008) Altered Expression of UVB-Induced Cytokines in Human Papillomavirus-Immortalized Epithelial Cells. Journal of General Virology, 89, 2461-2466. [Google Scholar] [CrossRef] [PubMed]
[34] Romanczuk, H., Thierry, F. and Howley, P.M. (1990) Mutational Analysis of Cis Elements Involved in E2 Modulation of Human Papillomavirus Type 16 P97 and Type 18 P105 Promoters. Journal of Virology, 64, 2849-2859. [Google Scholar] [CrossRef] [PubMed]
[35] Taniguchi, K. and Karin, M. (2014) IL-6 and Related Cytokines as the Critical Lynchpins between Inflammation and Cancer. Seminars in Immunology, 26, 54-74. [Google Scholar] [CrossRef] [PubMed]
[36] Chang, Q., Daly, L. and Bromberg, J. (2014) The IL-6 Feed-Forward Loop: A Driver of Tumorigenesis. Seminars in Immunology, 26, 48-53. [Google Scholar] [CrossRef] [PubMed]
[37] Luan, S., An, Z., Bi ,S., et al. (2018) Interleukin 6 Receptor (IL-6R) Was an Independent Prognostic Factor in Cervical Cancer. Histology and Histopathology, 33, 269-276.