MR-proANP、BNP及NT-proBNP在诊断慢性阻塞肺疾病急性加重合并急性心力衰竭时的研究进展
Research Progress of MR-proANP, BNP and NT-proBNP in the Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Combined with Acute Heart Failure
摘要: 急性心力衰竭(AHF)是慢性阻塞性肺疾病急性加重(AECOPD)患者最重要的合并症之一，与无AHF的患者相比，住院率和死亡率更高。AECOPD时其他急性事件(如AHF)的风险增加，需要优先对AECOPD并发AHF患者进行全面病情评估，因此对于AECOPD患者并发AHF的诊断尤为重要。由于AECOPD和AHF的症状和体征可出现部分重叠，AECOPD时是否伴有AHF的诊断具有较大难度。本综述将探究MR-proANP、BNP及NT-proBNP对AECOPD患者并发AHF的诊断价值的研究进展。
Abstract: Acute heart failure (AHF) is one of the most important comorbidities in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with higher rates of hospitalization and mortality compared to patients without AHF. The increased risk of other acute events (e.g., AHF) in the presence of AECOPD necessitates prioritization of patients with AECOPD complicated by AHF for a thorough evaluation of their condition. Therefore, it is particularly important for the diagnosis of AHF in patients with AECOPD. Since the signs and symptoms of AECOPD and AHF may partially overlap, the diagnosis of AHF in AECOPD can be difficult. In this review, we will investigate the progress of MR-proANP, BNP and NT-proBNP in the diagnosis of AHF in patients with AECOPD.
文章引用：王锐, 李元军, 陈卓, 刘常川, 王震. MR-proANP、BNP及NT-proBNP在诊断慢性阻塞肺疾病急性加重合并急性心力衰竭时的研究进展[J]. 临床个性化医学, 2024, 3(4): 1422-1427. https://doi.org/10.12677/jcpm.2024.34202

参考文献

[1] Holm, J., Cederholm, I., Alehagen, U., Lindahl, T.L. and Szabó, Z. (2020) Biomarker Dynamics in Cardiac Surgery: A Prospective Observational Study on MR-proADM, MR-proANP, hs-CRP and sP-Selectin Plasma Levels in the Perioperative Period. Biomarkers, 25, 296-304. [Google Scholar] [CrossRef] [PubMed]
[2] Ponikowski, P., Voors, A.A., Anker, S.D., Bueno, H., Cleland, J.G.F., Coats, A.J.S., et al. (2016) 2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure. European Journal of Heart Failure, 18, 891-975. [Google Scholar] [CrossRef] [PubMed]
[3] Cao, Z., Jia, Y. and Zhu, B. (2019) BNP and NT-ProBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine. International Journal of Molecular Sciences, 20, Article 1820. [Google Scholar] [CrossRef] [PubMed]
[4] Potocki, M., Breidthardt, T., Reichlin, T., Hartwiger, S., Morgenthaler, N.G., Bergmann, A., et al. (2009) Comparison of Midregional Pro‐Atrial Natriuretic Peptide with N‐Terminal Pro‐B‐Type Natriuretic Peptide in the Diagnosis of Heart Failure. Journal of Internal Medicine, 267, 119-129. [Google Scholar] [CrossRef] [PubMed]
[5] Tzikas, S., Keller, T., Wild, P.S., Schulz, A., Zwiener, I., Zeller, T., et al. (2013) Midregional Pro-Atrial Natriuretic Peptide in the General Population/insights from the Gutenberg Health Study. Clinical Chemistry and Laboratory Medicine, 51, 1125-1133. [Google Scholar] [CrossRef] [PubMed]
[6] Gegenhuber, A., Struck, J., Dieplinger, B., Poelz, W., Pacher, R., Morgenthaler, N.G., et al. (2007) Comparative Evaluation of B-Type Natriuretic Peptide, Mid-Regional Pro-A-Type Natriuretic Peptide, Mid-Regional Pro-Adrenomedullin, and Copeptin to Predict 1-Year Mortality in Patients with Acute Destabilized Heart Failure. Journal of Cardiac Failure, 13, 42-49. [Google Scholar] [CrossRef] [PubMed]
[7] Chenevier-Gobeaux, C., Guerin, S., André, S., Ray, P., Cynober, L., Gestin, S., et al. (2010) Midregional Pro-Atrial Natriuretic Peptide for the Diagnosis of Cardiac-Related Dyspnea According to Renal Function in the Emergency Department: A Comparison with B-Type Natriuretic Peptide (BNP) and N-Terminal ProBNP. Clinical Chemistry, 56, 1708-1717. [Google Scholar] [CrossRef] [PubMed]
[8] Maisel, A., Neath, S., Landsberg, J., Mueller, C., Nowak, R.M., Peacock, W.F., et al. (2012) Use of Procalcitonin for the Diagnosis of Pneumonia in Patients Presenting with a Chief Complaint of Dyspnoea: Results from the BACH (biomarkers in Acute Heart Failure) Trial. European Journal of Heart Failure, 14, 278-286. [Google Scholar] [CrossRef] [PubMed]
[9] Seronde, M., Gayat, E., Logeart, D., Lassus, J., Laribi, S., Boukef, R., et al. (2013) Comparison of the Diagnostic and Prognostic Values of B-Type and Atrial-Type Natriuretic Peptides in Acute Heart Failure. International Journal of Cardiology, 168, 3404-3411. [Google Scholar] [CrossRef] [PubMed]
[10] Aggarwal, P., Nayer, J. and Galwankar, S. (2014) Utility of Point-Of-Care Testing of Natriuretic Peptides (Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide) in the Emergency Department. International Journal of Critical Illness and Injury Science, 4, 209-215. [Google Scholar] [CrossRef] [PubMed]
[11] Tsai, S., Lin, Y., Chu, S., Hsu, C. and Cheng, S. (2010) Interpretation and Use of Natriuretic Peptides in Non-Congestive Heart Failure Settings. Yonsei Medical Journal, 51, 151-163. [Google Scholar] [CrossRef] [PubMed]
[12] Arrigo, M., Jessup, M., Mullens, W., Reza, N., Shah, A.M., Sliwa, K., et al. (2020) Acute Heart Failure. Nature Reviews Disease Primers, 6, Article No. 16. [Google Scholar] [CrossRef] [PubMed]
[13] Bozkurt, B., Coats, A.J.S., Tsutsui, H., Abdelhamid, C.M., Adamopoulos, S., Albert, N., et al. (2021) Universal Definition and Classification of Heart Failure: A Report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure. European Journal of Heart Failure, 23, 352-380. [Google Scholar] [CrossRef] [PubMed]
[14] Fonarow, G.C., Peacock, W.F., Phillips, C.O., Givertz, M.M. and Lopatin, M. (2007) Admission B-Type Natriuretic Peptide Levels and In-Hospital Mortality in Acute Decompensated Heart Failure. Journal of the American College of Cardiology, 49, 1943-1950. [Google Scholar] [CrossRef] [PubMed]
[15] MacDonald, M.I., Shafuddin, E., King, P.T., Chang, C.L., Bardin, P.G. and Hancox, R.J. (2016) Cardiac Dysfunction during Exacerbations of Chronic Obstructive Pulmonary Disease. The Lancet Respiratory Medicine, 4, 138-148. [Google Scholar] [CrossRef] [PubMed]
[16] de Lemos, J.A., McGuire, D.K. and Drazner, M.H. (2003) B-Type Natriuretic Peptide in Cardiovascular Disease. The Lancet, 362, 316-322. [Google Scholar] [CrossRef] [PubMed]
[17] Gupta, M. and Chhabra, S.K. (2022) Coexistent Chronic Obstructive Pulmonary Disease-Heart Failure: Mechanisms, Diagnostic and Therapeutic Dilemmas. The Indian Journal of Chest Diseases and Allied Sciences, 52, 225-238. [Google Scholar] [CrossRef] 
[18] van Dijk, S., Brusse-Keizer, M., Bucsán, C., Ploumen, E., van Beurden, W., van der Palen, J., et al. (2024) Lack of Evidence Regarding Markers Identifying Acute Heart Failure in Patients with COPD: An AI-Supported Systematic Review. International Journal of Chronic Obstructive Pulmonary Disease, 19, 531-541. [Google Scholar] [CrossRef] [PubMed]
[19] Su, X., Lei, T., Yu, H., Zhang, L., Feng, Z., Shuai, T., et al. (2023) NT-proBNP in Different Patient Groups of COPD: A Systematic Review and Meta-analysis. International Journal of Chronic Obstructive Pulmonary Disease, 18, 811-825. [Google Scholar] [CrossRef] [PubMed]
[20] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2014[J]. 中华心血管病杂志, 2014, 42(2): 98-122.
[21] Pavasini, R., Tavazzi, G., Biscaglia, S., Guerra, F., Pecoraro, A., Zaraket, F., et al. (2016) Amino Terminal Pro Brain Natriuretic Peptide Predicts All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis. Chronic Respiratory Disease, 14, 117-126. [Google Scholar] [CrossRef] [PubMed]
[22] Guo, X., Nie, H., Chen, Q., Chen, S., Deng, N., Li, R., et al. (2018) The Role of Plasma N-Terminal Brain Natriuretic Pro-Peptide in Diagnosing Elderly Patients with Acute Exacerbation of COPD Concurrent with Left Heart Failure. International Journal of Chronic Obstructive Pulmonary Disease, 13, 2931-2940. [Google Scholar] [CrossRef] [PubMed]
[23] Adrish, M., Nannaka, V., Cano, E., Bajantri, B. and Diaz-Fuentes, G. (2017) Significance of NT-Pro-BNP in Acute Exacerbation of COPD Patients without Underlying Left Ventricular Dysfunction. International Journal of Chronic Obstructive Pulmonary Disease, 12, 1183-1189. [Google Scholar] [CrossRef] [PubMed]
[24] Tinè, M., Bazzan, E., Semenzato, U., Biondini, D., Cocconcelli, E., Balestro, E., et al. (2020) Heart Failure Is Highly Prevalent and Difficult to Diagnose in Severe Exacerbations of COPD Presenting to the Emergency Department. Journal of Clinical Medicine, 9, Article 2644. [Google Scholar] [CrossRef] [PubMed]