基于免疫学探讨艾灸对老年人的影响
Exploring the Effect of Moxibustion on the Elderly Based on Immunology
DOI: 10.12677/tcm.2024.1312507, PDF,    科研立项经费支持
作者: 陈 丹, 彭逸飞：成都中医药大学针灸推拿学院，四川 成都；孙军刚：四川省中西医结合医院亚健康中心，四川 成都
关键词: 艾灸；老年人群；免疫衰老；免疫调节；Acupuncture and Moxibustion； Elderly Population； Immune Senescence； Immunomodulation
摘要: 免疫学是生物学的一个分支，其研究领域主要包括细胞免疫学、分子免疫学、免疫预防学等。随着年龄的增长，人体的免疫系统会发生衰老，伴随免疫功能降低，影响人体健康。与健康人群相比，免疫力低下的老年人更易感染病原微生物，其发病频率高，恢复时间长，甚至可能迁延不愈，发为他病。在我国，艾灸作为传统中医疗法之一，因其能够增强免疫且具有简便效廉的特点，被广泛应用于临床。文章基于此，探讨老年人群的免疫特点及艾灸的免疫调节作用，旨在为老年人保健及提高老年生活质量提供有价值的参考。
Abstract: Immunology is a branch of biology, and its research fields mainly include cellular immunology, molecular immunology, immunoprophylaxis, etc. As people age, the body’s immune system will undergo aging, accompanied by a decrease in immune function, affecting human health. Compared with healthy people, the elderly with weakened immunity are more susceptible to infection with pathogenic microorganisms, which have a high frequency of onset and a long recovery time and may even be prolonged and develop other diseases. In China, moxibustion, as one of the traditional Chinese medical treatments, is widely used in clinical practice because of its ability to enhance immunity and its simplicity and inexpensiveness. Based on this, this paper discusses the immune characteristics of the elderly population and the immunomodulatory effects of moxibustion, aiming to provide valuable references for the health care of the elderly and the improvement of their quality of life.
文章引用：陈丹, 彭逸飞, 孙军刚. 基于免疫学探讨艾灸对老年人的影响[J]. 中医学, 2024, 13(12): 3397-3403. https://doi.org/10.12677/tcm.2024.1312507

参考文献

[1] Elyahu, Y. and Monsonego, A. (2021) Thymus Involution Sets the Clock of the Aging T-Cell Landscape: Implications for Declined Immunity and Tissue Repair. Ageing Research Reviews, 65, Article 101231. [Google Scholar] [CrossRef] [PubMed]
[2] 朱庆磊, 王士雯. 老年人免疫系统改变与老年多器官功能衰竭[J]. 老年医学与保健, 2006(4): 244-248.
[3] 贺丽英, 孙蕴, 要文娟, 等. 2010-2016年中国老年人骨质疏松症患病率Meta分析[J]. 中国骨质疏松杂志, 2016, 22(12): 1590-1596.
[4] 蒋梦春, 胡洲映, 李双蕾, 等. 基于“肾藏精生髓主骨”理论探讨老年骨质疏松症与免疫系统的相关性[J]. 中医药学报, 2023, 51(8): 6-12.
[5] 仇小敏, 肖广辉. 巨噬细胞与老年慢性阻塞性肺疾病的相关性[J]. 实用老年医学, 2021, 35(12): 1225-1227.
[6] 黄美琼, 邢诒喜, 姚奇岑, 等. 老年类风湿关节炎患者lncRNA TUG1、Th17、Treg及其免疫应答产物水平变化和意义[J]. 中国老年学杂志, 2024, 44(17): 4144-4147.
[7] 昂沙尔·毕哈孜, 霍新慧, 丁霞. 灸药结合的研究进展[J]. 湖北中医杂志, 2023, 45(6): 59-62.
[8] 李竹青, 孔靖玮, 杨帆, 等. 灸法调体在中医“治未病”中的应用[J]. 世界中医药, 2023, 18(23): 3429-3243.
[9] Montecino-Rodriguez, E., Berent-Maoz, B. and Dorshkind, K. (2013) Causes, Consequences, and Reversal of Immune System Aging. Journal of Clinical Investigation, 123, 958-965. [Google Scholar] [CrossRef] [PubMed]
[10] McElhaney, J.E. and Effros, R.B. (2009) Immunosenescence: What Does It Mean to Health Outcomes in Older Adults? Current Opinion in Immunology, 21, 418-424. [Google Scholar] [CrossRef] [PubMed]
[11] Lian, J., Yue, Y., Yu, W. and Zhang, Y. (2020) Immunosenescence: A Key Player in Cancer Development. Journal of Hematology & Oncology, 13, Article No. 151. [Google Scholar] [CrossRef] [PubMed]
[12] Barbé-Tuana, F., Funchal, G., Schmitz, C.R.R., Maurmann, R.M. and Bauer, M.E. (2020) The Interplay between Immunosenescence and Age-Related Diseases. Seminars in Immunopathology, 42, 545-557. [Google Scholar] [CrossRef] [PubMed]
[13] Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A.A., Hirokawa, K., et al. (2021) Immunology of Aging: The Birth of Inflammaging. Clinical Reviews in Allergy & Immunology, 64, 109-122. [Google Scholar] [CrossRef] [PubMed]
[14] 王秋懿, 靳建亮. 衰老对免疫系统的影响及其干预机制的研究进展[J]. 医学研究与战创伤救治, 2023, 36(3): 311-316.
[15] Juhn, Y.J., Wi, C., Takahashi, P.Y., Ryu, E., King, K.S., Hickman, J.A., et al. (2023) Incidence of Respiratory Syncytial Virus Infection in Older Adults before and during the COVID-19 Pandemic. JAMA Network Open, 6, e2250634. [Google Scholar] [CrossRef] [PubMed]
[16] Addo, M., Cornely, O., Denkinger, M., Ertl, G., Herold, S., Pletz, M., et al. (2023) RSV Vaccination Strategies for High-Risk Patients 2023: A Collaborative Position Paper by Leading German Medical Societies and Organizations. Infection, 52, 285-288. [Google Scholar] [CrossRef] [PubMed]
[17] Li, J., Gong, X., Wang, Z., Chen, R., Li, T., Zeng, D., et al. (2020) Clinical Features of Familial Clustering in Patients Infected with 2019 Novel Coronavirus in Wuhan, China. Virus Research, 286, Article 198043. [Google Scholar] [CrossRef] [PubMed]
[18] Fane, M. and Weeraratna, A.T. (2019) How the Ageing Microenvironment Influences Tumour Progression. Nature Reviews Cancer, 20, 89-106. [Google Scholar] [CrossRef] [PubMed]
[19] López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M. and Kroemer, G. (2023) Hallmarks of Aging: An Expanding Universe. Cell, 186, 243-278. [Google Scholar] [CrossRef] [PubMed]
[20] Pawelec, G. (2018) Age and Immunity: What Is “Immunosenescence”? Experimental Gerontology, 105, 4-9. [Google Scholar] [CrossRef] [PubMed]
[21] Hotamisligil, G.S. (2017) Inflammation, Meta-Flammation and Immunometabolic Disorders. Nature, 542, 177-185. [Google Scholar] [CrossRef] [PubMed]
[22] Hotamisligil, G.S., Peraldi, P., Budavari, A., Ellis, R., White, M.F. and Spiegelman, B.M. (1996) IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-Α-and Obesity-Induced Insulin Resistance. Science, 271, 665-670. [Google Scholar] [CrossRef] [PubMed]
[23] Doran, M.F., Pond, G.R., Crowson, C.S., O’Fallon, W.M. and Gabriel, S.E. (2002) Trends in Incidence and Mortality in Rheumatoid Arthritis in Rochester, Minnesota, over a Forty-Year Period. Arthritis & Rheumatism, 46, 625-631. [Google Scholar] [CrossRef] [PubMed]
[24] 李红蓉, 马静, 尹玉洁, 等. 中医特色疗法的抗衰老研究进展[J]. 世界中医药, 2023, 18(24): 3608-3615.
[25] 蓝怡, 王健. 艾灸对免疫功能影响的用穴规律探讨[J]. 中医学报, 2019, 34(1): 214-217.
[26] 张军花, 单思, 王沐晨, 等. 基于肠道菌群探讨艾灸“命门” “关元”对健康大鼠免疫功能的影响[J]. 中国针灸, 2023, 43(10): 1157-1164.
[27] 徐小珊, 熊罗节, 马伟, 等. 隔药饼灸对慢性疲劳综合征大鼠免疫蛋白及T细胞调节因子Tim-3、LAG-3的影响[J]. 中国中医基础医学杂志, 2023, 29(10): 1666-1671.
[28] 李霞, 唐中生. 艾灸益气活血法对D-半乳糖致衰老大鼠免疫功能的影响[J]. 锦州医科大学学报, 2018, 39(3): 4-6+13.
[29] 付悦, 乌拉尔·达木拜克, 姜甜, 等. 针灸对免疫功能影响的研究进展[J]. 新疆中医药, 2022, 40(5): 139-141.
[30] 王江元, 郭志鹏, 袁野, 等. 老年肺炎患者PCT、hsCRP及免疫功能的变化及意义[J]. 中国实验诊断学, 2019, 23(12): 2113-2115.
[31] 田岳凤, 董成林, 李雷勇, 等. 隔药饼灸对不同年龄人群机体CD3、CD4及CD8的影响[J]. 世界中医药, 2017, 12(2): 405-407.
[32] 李青敏, 王海军, 张一平, 等. 针灸推拿对淋巴系统作用的研究进展[J]. 针灸临床杂志, 2017, 33(4): 72-76.
[33] 孙元. 针刺加艾灸治疗慢性疲劳综合征脾肾阳虚型的效果及对免疫功能的影响[J]. 中国医药导报, 2021, 18(21): 150-152+172.
[34] 邱晓伟, 来保勇, 牛文全, 等. 艾灸对放、化疗患者淋巴细胞及其亚群影响的Meta分析[J]. 辽宁中医杂志, 2021, 48(10): 162-167.
[35] 张玲璐. 艾灸脾俞穴治疗小儿慢性腹泻疗效观察[J]. 上海针灸杂志, 2016, 35(6): 697-699.
[36] 方明, 储浩然, 宋小鸽, 等. 基于肥大细胞脱颗粒探讨艾灸对腹泻型肠易激综合征大鼠结肠低度炎性反应的影响[J]. 中国针灸, 2024, 44(3): 283-294.
[37] 杨馨, 王燚, 杨慎峭, 等. 基于慢病毒介导的NLRP3过表达对艾灸调控实验性RA家兔关节滑膜液anti-CCP、RF水平的影响[J]. 世界科学技术-中医药现代化, 2023, 25(6): 2089-2096.
[38] 李丹, 胡凯文, 韩丽, 等. 艾灸对癌性疲劳小鼠免疫神经内分泌的影响[J]. 中华中医药杂志, 2023, 38(4): 1799-1803.