颗粒物对慢性肾脏病的影响及机制研究进展
Impacts and Mechanisms of Particulate Matter on Chronic Kidney Disease
DOI: 10.12677/acm.2024.14123262, PDF,    科研立项经费支持
作者: 马瑞坤, 张渝亭：承德医学院研究生学院，河北 承德；牛晓涛, 王俊芳：河北医科大学研究生学院，河北 石家庄；张 林, 宋晔宸：河北北方学院研究生学院，河北 张家口；刘艳玲, 王 晶, 鲁 华*：邢台市人民医院肾内科，河北 邢台
关键词: 大气颗粒物；流行病学；慢性肾脏病；生物学机制；Atmospheric Particulate Matter； Epidemiology； Chronic Kidney Disease； Biological Mechanisms
摘要: 慢性肾脏病(CKD)是全球性公共卫生问题，其发病率高、知晓率低，且与多种因素相关。近年来，大气颗粒物(PM)作为环境因素之一，与CKD的关联性受到广泛关注。该综述旨在探讨不同粒径的大气PM (包括PM10、PM2.5和PM1)对CKD发病风险的影响，并分析其潜在的生物学机制。研究表明，长期暴露于大气PM与CKD的发病率和进展风险增加有关。PM可能通过氧化应激、炎症反应、免疫反应、细胞自噬与凋亡以及血流动力学改变等途径影响肾脏功能。此外，PM中特定化学组分对肾脏的损害作用亦不容忽视。因此，该综述强调了制定有效的PM干预政策对于预防和控制CKD的重要性，并为未来的研究方向提供了新的视角。
Abstract: Chronic kidney disease (CKD) is a prevalent global public health concern characterized by high incidence rates, low awareness levels, and a multitude of associated factors. Recently, the correlation between atmospheric particulate matter (PM), as one of the environmental factors, and CKD has garnered substantial attention. This review aims to investigate the impacts of atmospheric PM of varying particle sizes, including PM10, PM2.5, and PM1, on the susceptibility to CKD and delve into the potential biological mechanisms. Findings indicate that long-term exposure to atmospheric PM is linked to a heightened incidence and risk of progression of CKD. PM may affect renal function via pathways involving oxidative stress, inflammation, immune response, cellular autophagy and apoptosis, and hemodynamic changes. Furthermore, the detrimental effects of specific chemical components within PM on kidney health should be considered. Consequently, this review highlights the necessity of implementing effective PM intervention policies for the prevention and control of CKD, thereby offering novel research avenues for exploration in the future.
文章引用：马瑞坤, 牛晓涛, 张渝亭, 王俊芳, 张林, 宋晔宸, 刘艳玲, 王晶, 鲁华. 颗粒物对慢性肾脏病的影响及机制研究进展[J]. 临床医学进展, 2024, 14(12): 1629-1637. https://doi.org/10.12677/acm.2024.14123262

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