Nrf2靶向调控铁死亡在肺部疾病中的研究进展
Research Progress of Nrf2 Targeting Ferroptosis in Lung Diseases
DOI: 10.12677/jcpm.2024.34380, PDF,    科研立项经费支持
作者: 汪 珍, 李 娜*：重庆医科大学附属第二医院呼吸内科，重庆
关键词: 铁死亡；Nrf2；肺部疾病；Ferroptosis； Nrf2； Lung Diseases
摘要: 铁死亡是近年来发现的一种独特的细胞死亡形式，其特征是铁依赖性的脂质过氧化。铁过载、膜磷脂中不受控制和压倒性的脂质过氧化、氧化应激与抗氧化调节失衡是铁死亡发生的重要条件。谷胱甘肽/谷胱甘肽过氧化物酶4 (GSH/GPX4)通路、ACSL4 (酰基辅酶A合成酶长链家族成员4)、FSP1 (铁死亡抑制蛋白1)-CoQ 10 (辅酶Q 10)-NAD(P)H通路、GCH1 (GTP环水解酶1)-BH 4 (四氢生物蝶呤)通路、线粒体内膜的DHODH (二氢乳清酸脱氢酶)-CoQ 10轴都可以调控细胞铁死亡，而核因子E2相关因子2 (Nrf2/NFE2L2)可以调控上述多种通路，目前已被证明在呼吸系统疾病治疗和铁死亡调节中起关键作用。在这篇综述中，我们将简要概述铁死亡的发生机制，并强调Nrf2调控铁死亡的机制。我们还强调了铁死亡和Nrf2在呼吸系统疾病过程中的作用，并为进一步呼吸系统疾病治疗过程中Nrf2与铁死亡之间的关系提供了理论依据。
Abstract: Ferroptosis is a unique form of cell death identified in recent years, characterized by iron-dependent lipid peroxidation. Iron overload, uncontrolled and overwhelming lipid peroxidation in membrane phospholipids, and an imbalance between oxidative stress and antioxidant regulation are important conditions for ferroptosis. The glutathione/glutathione peroxidase 4 (GSH/GPX4) pathway, ACSL4 (acyl-coenzyme A synthetase long-chain family member 4), FSP1 (iron death inhibitory protein 1)-CoQ 10 (coenzyme Q 10)-NAD(P)H pathway, GCH1 (GTP cycloheximide 1)-BH 4 (tetrahydrobiopterin) pathway, and the DHODH (dihydroorotate dehydrogenase)-CoQ 10 axis in the inner mitochondrial membrane all regulate cellular ferroptosis, while the nuclear factor erythroid 2-related factor 2 (Nrf2/NFE2L2) regulates many of the above pathways, which have now been shown to play a key role in respiratory disease therapy and iron death regulation. In this review, we provide a brief overview of the mechanisms by which ferroptosis occurs and emphasize the mechanisms by which Nrf2 regulates ferroptosis. We also emphasize the role of ferroptosis and Nrf2 in respiratory diseases and provide a theoretical rationale for the relationship between Nrf2 and ferroptosis during further respiratory disease therapy.
文章引用：汪珍, 李娜. Nrf2靶向调控铁死亡在肺部疾病中的研究进展[J]. 临床个性化医学, 2024, 3(4): 2672-2681. https://doi.org/10.12677/jcpm.2024.34380

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