桑类药物在女性不孕症中的应用
Application of Mulberry Drugs in Female Infertility
DOI: 10.12677/jcpm.2024.34387, PDF,   
作者: 罗 丽, 任嘉渊, 李岱潞, 袁卓珺*：云南中医药大学第一附属医院男科/生殖医学科，云南 昆明
关键词: 桑类药物；女性不孕症；综述；Mulberry Drugs； Female Infertility； Summary
摘要: 桑类药物属于桑科植物，具有补肝肾填精髓的功效，临床用于预防和治疗多种疾病。现代研究发现，桑类药物含有丰富的活性成分，具有多种药理作用，因此就桑类药物的功效、活性成分、治疗女性不孕症的药理作用机制及临床应用进行综述。据考究，桑类药物内富含黄酮类、生物碱类、槲皮素、萜类等诸多活性成分，它们凭借抗氧化、抗炎及激素调节等诸多机制，对女性生殖系统疾病具备治疗及辅助治疗的功效，从而有效促进了女性生殖功能的恢复与改善。
Abstract: Mulberry drugs belong to the mulberry family plant, with the effect of filling the liver and kidney essence and being clinically used for the prevention and treatment of a variety of diseases. Modern research has found that mulberry drugs contain rich active ingredients and have a variety of pharmacological effects. Therefore, the efficacy, active ingredients, pharmacological mechanism and clinical application of mulberry drugs in the treatment of female infertility are reviewed. It was found that mulberry drugs contain flavonoids, alkaloids, quercetin, terpenoids, alkaloids and other active ingredients, and have therapeutic and auxiliary therapeutic effects on female reproductive system diseases through antioxidant, anti-inflammatory and hormone regulation, so as to improve female reproductive function.
文章引用：罗丽, 任嘉渊, 李岱潞, 袁卓珺. 桑类药物在女性不孕症中的应用[J]. 临床个性化医学, 2024, 3(4): 2733-2737. https://doi.org/10.12677/jcpm.2024.34387

参考文献

[1] 石月, 孙莉莉, 丁昕, 等. 徐州地区女性不孕症影响因素的病例对照研究[J]. 现代预防医学, 2016, 43(10): 1778-1781.
[2] Pellestor, F., Andréo, B., Arnal, F., Humeau, C. and Demaille, J. (2003) Maternal Aging and Chromosomal Abnormalities: New Data Drawn from in Vitro Unfertilized Human Oocytes. Human Genetics, 112, 195-203. [Google Scholar] [CrossRef] [PubMed]
[3] 黄小琼, 邓光尧, 汪欢生, 等. 育龄女性不孕的影响因素及治疗方式研究[J]. 中国当代医药, 2016, 23(14): 63-65+68.
[4] 郭蔼春. 黄帝内经素问语译[M]. 北京: 人民卫生出版社, 1992: 5, 14.
[5] Chan, E.W., Lye, P.Y. and Wong, S.K. (2016) Phytochemistry, Pharmacology, and Clinical Trials of Morus Alba. Chinese Journal of Natural Medicines, 14, 17-30.
[6] Zhang, L., Su, S., Zhu, Y., Guo, J., Guo, S., Qian, D., et al. (2019) Mulberry Leaf Active Components Alleviate Type 2 Diabetes and Its Liver and Kidney Injury in Db/db Mice through Insulin Receptor and Tgf-Β/Smads Signaling Pathway. Biomedicine & Pharmacotherapy, 112, Article ID: 108675. [Google Scholar] [CrossRef] [PubMed]
[7] Park, S.W., Shin, K.C., Yoou, S., Park, H.J., Eun, S.H., Bae, Y.M., et al. (2018) Effects of an Ethanolic Extract of Mulberry Fruit on Blood Pressure and Vascular Remodeling in Spontaneous Hypertensive Rats. Clinical and Experimental Hypertension, 41, 280-286. [Google Scholar] [CrossRef] [PubMed]
[8] 周莹, 周扬. 《神农本草经》妇科病症用药特点探析[J]. 中华中医药杂志, 2024, 39(2): 1016-1021.
[9] Dhandapani, K., Kodavanji, B., Nithyananda Madom Anantharaya, V. and Arun Kumar, N. (2021) Prevalence and Distribution of Causes of Infertility According to Women’s Age—A Cross-Sectional Study in a Tertiary Healthcare Hospital Setup. Journal of Basic and Clinical Physiology and Pharmacology, 34, 27-32. [Google Scholar] [CrossRef] [PubMed]
[10] 高敏, 刘慧聪, 徐莲薇, 等. 孙卓君从肝肾调治排卵障碍性不孕症[J]. 长春中医药大学学报, 2016(1): 50-52.
[11] 阚潘宇, 谭若兰, 王烷馨, 等. 基于数据挖掘探析尤昭玲教授治疗不孕症的用药规律[J]. 云南中医中药杂志, 2024, 45(4): 41-45.
[12] Wei, M., Mahady, G., Liu, D., Zheng, Z. and Lu, Y. (2016) Astragalin, a Flavonoid from Morus Alba (Mulberry) Increases Endogenous Estrogen and Progesterone by Inhibiting Ovarian Granulosa Cell Apoptosis in an Aged Rat Model of Menopause. Molecules, 21, Article No. 675. [Google Scholar] [CrossRef] [PubMed]
[13] Shanti, A., Santanam, N., Morales, A.J., Parthasarathy, S. and Murphy, A.A. (1999) Autoantibodies to Markers of Oxidative Stress Are Elevated in Women with Endometriosis. Fertility and Sterility, 71, 1115-1118. [Google Scholar] [CrossRef] [PubMed]
[14] Huang, Z., Lv, Z., Dai, H., Li, S., Jiang, J., Ye, N., et al. (2021) Dietary Mulberry‐Leaf Flavonoids Supplementation Improves Liver Lipid Metabolism and Ovarian Function of Aged Breeder Hens. Journal of Animal Physiology and Animal Nutrition, 106, 1321-1332. [Google Scholar] [CrossRef] [PubMed]
[15] Costa, J.P.L., Brito, H.O., Galvão‐Moreira, L.V., Brito, L.G.O., Costa‐Paiva, L. and Brito, L.M.O. (2019) Randomized Double‐Blind Placebo‐Controlled Trial of the Effect of Morus nigra L. (Black Mulberry) Leaf Powder on Symptoms and Quality of Life among Climacteric Women. International Journal of Gynecology & Obstetrics, 148, 243-252. [Google Scholar] [CrossRef] [PubMed]
[16] Agarwal, A., Aponte-Mellado, A., Premkumar, B.J., Shaman, A. and Gupta, S. (2012) The Effects of Oxidative Stress on Female Reproduction: A Review. Reproductive Biology and Endocrinology, 10, Article No. 49. [Google Scholar] [CrossRef] [PubMed]
[17] Scutiero, G., Iannone, P., Bernardi, G., Bonaccorsi, G., Spadaro, S., Volta, C.A., et al. (2017) Oxidative Stress and Endometriosis: A Systematic Review of the Literature. Oxidative Medicine and Cellular Longevity, 2017, Article ID: 7265238. [Google Scholar] [CrossRef] [PubMed]
[18] Pourteymour Fard Tabrizi, F., Hajizadeh-Sharafabad, F., Vaezi, M., Jafari-Vayghan, H., Alizadeh, M. and Maleki, V. (2020) Quercetin and Polycystic Ovary Syndrome, Current Evidence and Future Directions: A Systematic Review. Journal of Ovarian Research, 13, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[19] 盐山, 张锡纯. 医学衷中参西录(合订本) [M]. 石家庄: 河北人民出版社, 1977: 258.
[20] 吴红卫, 叶一萍, 郑宋明, 等. 寿胎丸治疗月经不调81例疗效观察[J]. 浙江中医杂志, 2011, 46(11): 811-812.
[21] 季丹, 谈勇. 谈勇运用滋阴补阳方序贯治疗反复移植失败经验撷菁[J]. 中国中医基础医学杂志, 2017, 23(12): 1783-1784, 1789.
[22] 贺艳, 张乐乐, 陈旭佳, 等. 菟丝子-桑寄生改善小鼠卵巢储备功能及子宫内膜容受性[J]. 中药与临床, 2022, 13(5): 48-51.
[23] 刘有志, 朱志飞, 吴月峰, 等. 桑源药材的历史沿革及现代研究进展[J]. 中成药, 2023, 45(1): 175-184.
[24] 吴月峰, 陈定芳, 朱志飞, 等. 桑源中药用药规律及超分子作用机制研究[J]. 湖南中医药大学学报, 2021, 41(11): 1807-1812.