间充质干细胞工程化修饰策略在基于干细胞治疗中的研究进展
Research Progress of Mesenchymal Stem Cell Engineering Modification Strategies in Stem Cell-Based Therapy
DOI: 10.12677/acm.2025.151300, PDF,    科研立项经费支持
作者: 严萍萍：重庆医科大学附属口腔医院正畸科，重庆；钟雯婕*：口腔疾病与生物医学重庆市重点实验室，重庆；高 翔*：重庆市高校市级口腔生物医学工程重点实验室，重庆
关键词: 间充质干细胞；干细胞治疗；工程化修饰；组织工程；Mesenchymal Stem Cells； Stem Cell Therapy； Engineering Modification； Tissue Engineering
摘要: 间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能，可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的，但在临床应用中，其疗效和安全性仍存在局限性，主要体现在MSCs靶向性不足、分化能力受限、体内存活率低及药物递送效率不足等方面。为解决这些问题，目前出现多种工程化修饰技术，包括基因工程、表面修饰、物理化学修饰和组织工程等，以提高MSCs疗法的治疗效果和安全性。本文详细介绍了不同工程化修饰策略，并重点阐述各工程化修饰下MSCs功能化的实现和临床应用前景。
Abstract: Mesenchymal stem cells (MSCs) hold significant promise for the treatment of a wide range of diseases, owing to their multi-lineage differentiation potential, self-renewal capabilities, and immune regulatory properties. Although MSCs-based therapies have demonstrated safety and efficacy to some extent, their clinical application remains limited. These limitations are primarily due to challenges such as insufficient targeting of MSCs, restricted differentiation capacity, low in vivo survival rates, and poor drug delivery efficiency. To address these issues, a variety of engineering strategies, including genetic modification, surface functionalization, physicochemical modification, and tissue engineering, have been developed to enhance the therapeutic efficacy and safety of MSCs therapies. This paper provides a comprehensive overview of these engineering approaches and discusses their potential for future clinical application in MSCs-based therapies.
文章引用：严萍萍, 钟雯婕, 高翔. 间充质干细胞工程化修饰策略在基于干细胞治疗中的研究进展[J]. 临床医学进展, 2025, 15(1): 2286-2296. https://doi.org/10.12677/acm.2025.151300

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