免疫出生缺陷的真菌易感机制及新型抗真菌治疗
The Fungal Susceptibility Mechanism of Inborn Errors of Immunity and Novel Antifungal Therapies
DOI: 10.12677/acm.2025.151302, PDF,   
作者: 陈香霓, 张志勇*：重庆医科大学附属儿童医院风湿免疫科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童感染与免疫罕见病重庆市重点实验室，重庆
关键词: 免疫出生缺陷；真菌；致病机制；新型抗真菌治疗；Inborn Errors of Immunity； Fungi； Pathogenic Mechanism； Novel Antifungal Therapies
摘要: 免疫出生缺陷(IEI)是由基因突变导致的，以免疫系统结构或功能受损为主要表现的临床综合征。IEI对真菌易感且感染较重，已成为该病患者死亡的重要原因之一。目前传统抗真菌药物存在毒副作用明显及耐药问题，导致IEI患者抗真菌治疗困难。探究IEI常见易感真菌的致病机制及新型疗法有助于开展早期、有效诊疗，改善患者预后。
Abstract: Inborn errors of immunity (IEI) are clinical syndromes manifested by impaired immune system structure or function, induced by genetic mutations. Invasive fungal infections (IEI) are a significant cause of mortality in patients with this condition, as they are highly susceptible to fungal infections, which tend to be severe. At present, the application of traditional antifungal drugs shows significant toxic side effects and resistance problems, making antifungal treatment difficult for patients with IEI. The exploration of the pathogenic mechanisms and novel therapies of common susceptible fungi in IEI can assist early and effective diagnosis and treatment, and improve the prognosis of patients.
文章引用：陈香霓, 张志勇. 免疫出生缺陷的真菌易感机制及新型抗真菌治疗[J]. 临床医学进展, 2025, 15(1): 2307-2316. https://doi.org/10.12677/acm.2025.151302

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