川崎病心血管远期并发症及治疗
Long-Term Cardiovascular Complications and Treatment of Kawasaki Disease
DOI: 10.12677/acm.2025.152313, PDF,   
作者: 吕 鑫, 钟红平*：延安大学医学院，陕西 延安；延安大学附属医院儿科，陕西 延安
关键词: 川崎病；心血管并发症；治疗；Kawasaki Disease； Cardiovascular Complications； Heal
摘要: 川崎病(Kawasaki disease, KD)是一种病因不明且发病机制尚不清楚的一种疾病，又被称为粘膜皮肤淋巴结综合征，其典型特征是急性系统性血管炎，主要发生在5岁以下儿童。患有该疾病的患者大多数预后良好，但由于其远期对心血管的严重损伤，使得我们不得不对KD进行特别关注。
Abstract: Kawasaki disease (KD) is a disease with unknown etiology and pathogenesis, also known as mucocutaneous lymph node syndrome, which is typically characterized by acute systemic vasculitis, mainly in children under 5 years of age. Most patients with this disease have a good prognosis, but we have to pay special attention to KD because of its serious long-term cardiovascular damage.
文章引用：吕鑫, 钟红平. 川崎病心血管远期并发症及治疗[J]. 临床医学进展, 2025, 15(2): 45-49. https://doi.org/10.12677/acm.2025.152313

参考文献

[1] Manlhiot, C., O'Shea, S., Bernknopf, B., LaBelle, M., Chahal, N., Dillenburg, R.F., et al. (2018) Epidemiology of Kawasaki Disease in Canada 2004 to 2014: Comparison of Surveillance Using Administrative Data vs Periodic Medical Record Review. Canadian Journal of Cardiology, 34, 303-309. [Google Scholar] [CrossRef] [PubMed]
[2] Newburger, J.W., Takahashi, M., Gerber, M.A., Gewitz, M.H., Tani, L.Y., Burns, J.C., et al. (2004) Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease. Circulation, 110, 2747-2771. [Google Scholar] [CrossRef] [PubMed]
[3] Fukazawa, R., Kobayashi, J., Ayusawa, M., Hamada, H., Miura, M., Mitani, Y., et al. (2020) JCS/JSCS 2020 Guideline on Diagnosis and Management of Cardiovascular Sequelae in Kawasaki Disease. Circulation Journal, 84, 1348-1407. [Google Scholar] [CrossRef] [PubMed]
[4] Kato, H., Sugimura, T., Akagi, T., Sato, N., Hashino, K., Maeno, Y., et al. (1996) Long-Term Consequences of Kawasaki Disease. Circulation, 94, 1379-1385. [Google Scholar] [CrossRef] [PubMed]
[5] Xie, L., Yan, W., Huang, M., Huang, M., Chen, S., Huang, G., et al. (2020) Epidemiologic Features of Kawasaki Disease in Shanghai from 2013 through 2017. Journal of Epidemiology, 30, 429-435. [Google Scholar] [CrossRef] [PubMed]
[6] 时艳艳. 川崎病冠状动脉损害及其转归的回顾性研究[D]: [硕士学位论文]. 上海: 复旦大学, 2011.
[7] 杜忠东, 夏顺刚, 王阳, 等. 选择性冠状动脉造影诊断川崎病合并左冠状动脉主干完全闭塞一例[J]. 中华心血管病杂志, 2005, 33(3): 281-282.
[8] Xiong, Y., Zhang, Y.L. and Du, Z.D. (2021) Middle and Long-Term Follow-Up of 101 Children with Giant Coronary Artery Aneurysm of Kawasaki Disease. Chinese Journal of Pediatrics, 59, 101-106.
[9] Wei, Y.J., Zhao, X.L., Liu, B.M., Niu, H. and Li, Q. (2015) Cardiac Complications in 38 Cases of Kawasaki Disease with Coronary Artery Aneurysm Diagnosed by Echocardiography. Echocardiography, 33, 764-770. [Google Scholar] [CrossRef] [PubMed]
[10] 黄国英. 川崎病流行病学研究进展和思考[J]. 中国小儿急救医学, 2020, 27(9): 641-644.
[11] Harada, M., Yokouchi, Y., Oharaseki, T., Matsui, K., Tobayama, H., Tanaka, N., et al. (2012) Histopathological Characteristics of Myocarditis in Acute-Phase Kawasaki Disease. Histopathology, 61, 1156-1167. [Google Scholar] [CrossRef] [PubMed]
[12] Yutani, C., Go, S., Kamiya, T., et al. (1981) Cardiac Biopsy of Kawasaki Disease. Archives of Pathology & Laboratory Medicine, 105, 470-473.
[13] Akagi, T., Kato, H., Inoue, O., Sato, N. and Imamura, K. (1990) Valvular Heart Disease in Kawasaki Syndrome: Incidence and Natural History. American Heart Journal, 120, 366-372. [Google Scholar] [CrossRef] [PubMed]
[14] 钱碧莹, 赵建美. 川崎病心血管并发症的研究进展[J]. 交通医学, 2020, 34(1): 8-10+14.
[15] Zhao, Z., Yuan, Y., Gao, L., Li, Q., Wang, Y. and Zhao, S. (2024) Predicting Kawasaki Disease Shock Syndrome in Children. Frontiers in Immunology, 15, Article 1400046. [Google Scholar] [CrossRef] [PubMed]
[16] Kanegaye, J.T., Wilder, M.S., Molkara, D., Frazer, J.R., Pancheri, J., Tremoulet, A.H., et al. (2009) Recognition of a Kawasaki Disease Shock Syndrome. Pediatrics, 123, e783-e789. [Google Scholar] [CrossRef] [PubMed]
[17] Qiu, H., Li, C., He, Y., Weng, F., Shi, H., Pan, L., et al. (2019) Association between Left Ventricular Ejection Fraction and Kawasaki Disease Shock Syndrome. Cardiology in the Young, 29, 178-184. [Google Scholar] [CrossRef] [PubMed]
[18] Maddox, R.A., Person, M.K., Kennedy, J.L., Leung, J., Abrams, J.Y., Haberling, D.L., et al. (2020) Kawasaki Disease and Kawasaki Disease Shock Syndrome Hospitalization Rates in the United States, 2006-2018. Pediatric Infectious Disease Journal, 40, 284-288. [Google Scholar] [CrossRef] [PubMed]
[19] 柳颐龄, 王献民, 陈婷婷, 等. 氯吡格雷联合阿司匹林对川崎病并发中小型冠状动脉瘤患儿抗血栓治疗的疗效及安全性研究[J]. 中国当代儿科杂志, 2019, 21(8): 801-805.
[20] Kuo, H. (2017) Preventing Coronary Artery Lesions in Kawasaki Disease. Biomedical Journal, 40, 141-146. [Google Scholar] [CrossRef] [PubMed]
[21] 杜忠东, 冯迎军, 焦富勇. 静脉输注免疫球蛋白在儿童川崎病中应用的专家共识[J]. 中国当代儿科杂志, 2021, 23(9): 867-876.
[22] Kobayashi, T., Saji, T., Otani, T., Takeuchi, K., Nakamura, T., Arakawa, H., et al. (2012) Efficacy of Immunoglobulin Plus Prednisolone for Prevention of Coronary Artery Abnormalities in Severe Kawasaki Disease (RAISE Study): A Randomised, Open-Label, Blinded-Endpoints Trial. The Lancet, 379, 1613-1620. [Google Scholar] [CrossRef] [PubMed]
[23] Kobayashi, T., Inoue, Y., Takeuchi, K., Okada, Y., Tamura, K., Tomomasa, T., et al. (2006) Prediction of Intravenous Immunoglobulin Unresponsiveness in Patients with Kawasaki Disease. Circulation, 113, 2606-2612. [Google Scholar] [CrossRef] [PubMed]
[24] 刘玉玲, 李立浩, 马力忠, 等. 川崎病伴心功能不全3例[J]. 中国实用儿科杂志, 2011, 26(11): 879-880.
[25] Fukunaga, S., Egashira, A., Arinaga, K., et al. (1996) Aortic Valve Replacement for Aortic Regurgitation Due to Kawasaki Disease: Report of Two Cases. Journal of Heart Valve Disease, 5, 231-234.
[26] 黄平, 程佩萱. 川崎病致心脏瓣膜病变的诊断及治疗[J]. 实用儿科临床杂志, 2003(4): 310-312.
[27] Tremoulet, A.H., Jain, S. and Burns, J.C. (2015) Evaluating a Novel Treatment for Coronary Artery Inflammation in Acute Kawasaki Disease: A Phase I/II A Trial of Atorvastatin. Expert Opinion on Orphan Drugs, 3, 967-970. [Google Scholar] [CrossRef] [PubMed]
[28] Eleftheriou, D., Levin, M., Shingadia, D., Tulloh, R., Klein, N. and Brogan, P. (2013) Management of Kawasaki Disease. Archives of Disease in Childhood, 99, 74-83. [Google Scholar] [CrossRef] [PubMed]

为你推荐