剪切波弹性成像无创诊断MAFLD患者肝纤维化的应用进展
Advances in the Application of Shear Wave Elastography in Noninvasive Diagnosis of Liver Fibrosis in MAFLD
DOI: 10.12677/acm.2025.152388, PDF,   
作者: 刘钰莹, 张群霞*：重庆医科大学附属第二医院超声医学科，重庆
关键词: MAFLD；NAFLD；肝纤维化；剪切波弹性成像；MAFLD； NAFLD； Liver Fibrosis； Shear Wave Elastography
摘要: 代谢相关性脂肪肝病(MAFLD)是一种正在全球范围流行的慢性肝病，曾用名非酒精性脂肪肝病(NAFLD)。肝纤维化是MAFLD病情进展中的重要阶段，随着肝纤维化的发展有极大风险进展为肝硬化、肝癌。对MAFLD患者进行肝纤维化评估可以达到早期干预和改善预后的目的，剪切波弹性成像(SWE)是一种肝纤维化诊断的非侵入性技术，以其简便、快捷、高效的检查特点在临床得到了广泛的应用。本文旨在对当前SWE在MAFLD肝纤维化诊断中的应用进展进行综述。
Abstract: Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease that is becoming endemic worldwide, formerly known as non-alcoholic fatty liver disease (NAFLD). Liver fibrosis is an important stage in the progression of MAFLD, and with the development of liver fibrosis, there is a great risk of progression to liver cirrhosis and liver cancer. Shear wave elastography (SWE) is a non-invasive technique for the diagnosis of liver fibrosis, which has been widely used in clinical practice due to its simple, fast and efficient examination characteristics. This article is to review the current progress in the application of SWE in the diagnosis of liver fibrosis in MAFLD.
文章引用：刘钰莹, 张群霞. 剪切波弹性成像无创诊断MAFLD患者肝纤维化的应用进展[J]. 临床医学进展, 2025, 15(2): 634-639. https://doi.org/10.12677/acm.2025.152388

参考文献

[1] Kadi, D., Loomba, R. and Bashir, M.R. (2024) Diagnosis and Monitoring of Nonalcoholic Steatohepatitis: Current State and Future Directions. Radiology, 310, e222695. [Google Scholar] [CrossRef] [PubMed]
[2] Eslam, M., Newsome, P.N., Sarin, S.K., Anstee, Q.M., Targher, G., Romero-Gomez, M., et al. (2020) A New Definition for Metabolic Dysfunction-Associated Fatty Liver Disease: An International Expert Consensus Statement. Journal of Hepatology, 73, 202-209. [Google Scholar] [CrossRef] [PubMed]
[3] Eslam, M., Sarin, S.K., Wong, V.W., Fan, J., Kawaguchi, T., Ahn, S.H., et al. (2020) The Asian Pacific Association for the Study of the Liver Clinical Practice Guidelines for the Diagnosis and Management of Metabolic Associated Fatty Liver Disease. Hepatology International, 14, 889-919. [Google Scholar] [CrossRef] [PubMed]
[4] Hagström, H., Nasr, P., Ekstedt, M., Hammar, U., Stål, P., Hultcrantz, R., et al. (2017) Fibrosis Stage but Not NASH Predicts Mortality and Time to Development of Severe Liver Disease in Biopsy-Proven NAFLD. Journal of Hepatology, 67, 1265-1273. [Google Scholar] [CrossRef] [PubMed]
[5] van Doorn, D.J., Holleboom, A.G., Takkenberg, R.B., Verheij, J. and Lantinga, M.A. (2023) Can Liver Stiffness Measurement Accurately Predict Disease Progression and Clinical Outcome in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Bridging Fibrosis or Cirrhosis? Hepatobiliary Surgery and Nutrition, 12, 912-915. [Google Scholar] [CrossRef] [PubMed]
[6] DeWall, R.J. (2013) Ultrasound Elastography: Principles, Techniques, and Clinical Applications. Critical Reviews in Biomedical Engineering, 41, 1-19. [Google Scholar] [CrossRef] [PubMed]
[7] Frulio, N. and Trillaud, H. (2013) Ultrasound Elastography in Liver. Diagnostic and Interventional Imaging, 94, 515-534. [Google Scholar] [CrossRef] [PubMed]
[8] Barr, R.G., Wilson, S.R., Rubens, D., Garcia-Tsao, G. and Ferraioli, G. (2020) Update to the Society of Radiologists in Ultrasound Liver Elastography Consensus Statement. Radiology, 296, 263-274. [Google Scholar] [CrossRef] [PubMed]
[9] Patil, P.V., Julakanti, S. and Dhadve, R.U. (2024) Point Shear Wave Elastography for Assessment of Liver Stiffness in Normal Individuals and in Patients with Non-Alcoholic Fatty Liver Disease. Cureus, 16, e70711. [Google Scholar] [CrossRef] [PubMed]
[10] Kobayashi, T., Nakatsuka, T., Sato, M., Soroida, Y., Hikita, H., Gotoh, H., et al. (2025) Diagnostic Performance of Two-Dimensional Shear Wave Elastography and Attenuation Imaging for Fibrosis and Steatosis Assessment in Chronic Liver Disease. Journal of Medical Ultrasonics, 52, 95-103. [Google Scholar] [CrossRef] [PubMed]
[11] Karagiannakis, D.S., Markakis, G., Lakiotaki, D., Cholongitas, E., Vlachogiannakos, J. and Papatheodoridis, G. (2022) Comparing 2D-Shear Wave to Transient Elastography for the Evaluation of Liver Fibrosis in Nonalcoholic Fatty Liver Disease. European Journal of Gastroenterology & Hepatology, 34, 961-966. [Google Scholar] [CrossRef] [PubMed]
[12] Yoo, J., Lee, J.M., Joo, I. and Yoon, J.H. (2020) Assessment of Liver Fibrosis Using 2-Dimensional Shear Wave Elastography: A Prospective Study of Intra-and Inter-Observer Repeatability and Comparison with Point Shear Wave Elastography. Ultrasonography, 39, 52-59. [Google Scholar] [CrossRef] [PubMed]
[13] Nakano, M., Kuromatsu, R. and Kawaguchi, T. (2023) Ultrasonographic Assessment of Tissue Stiffness: Recent Progress in Transient Elastography and Shear Wave Elastography in the Liver and Various Organs. The Kurume Medical Journal, 70, 1-10. [Google Scholar] [CrossRef] [PubMed]
[14] Berzigotti, A., Tsochatzis, E., Boursier, J., Castera, L., Cazzagon, N., Friedrich-Rust, M., et al. (2021) EASL Clinical Practice Guidelines on Non-Invasive Tests for Evaluation of Liver Disease Severity and Prognosis—2021 Update. Journal of Hepatology, 75, 659-689. [Google Scholar] [CrossRef] [PubMed]
[15] Chen, Z., Ma, Y., Cai, J., Sun, M., Zeng, L., Wu, F., et al. (2022) Serum Biomarkers for Liver Fibrosis. Clinica Chimica Acta, 537, 16-25. [Google Scholar] [CrossRef] [PubMed]
[16] Ozturk, A., Olson, M.C., Samir, A.E. and Venkatesh, S.K. (2021) Liver Fibrosis Assessment: MR and US Elastography. Abdominal Radiology, 47, 3037-3050. [Google Scholar] [CrossRef] [PubMed]
[17] Furlan, A., Tublin, M.E., Yu, L., Chopra, K.B., Lippello, A. and Behari, J. (2020) Comparison of 2D Shear Wave Elastography, Transient Elastography, and MR Elastography for the Diagnosis of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease. American Journal of Roentgenology, 214, W20-W26. [Google Scholar] [CrossRef] [PubMed]
[18] Dillman, J.R. and Trout, A.T. (2023) Multisample Ultrasound Point Shear Wave Elastography of the Liver: Repeatability and Agreement with Conventional Point Shear Wave Elastography. Journal of Ultrasound in Medicine, 42, 2749-2756. [Google Scholar] [CrossRef] [PubMed]
[19] Elmeliegy, A.M. and Guddati, M.N. (2024) Multi-Acquisition Multi-Resolution Full-Waveform Shear Wave Elastography for Reconstructing Tissue Viscoelasticity. Physics in Medicine & Biology, 69, Article 245013. [Google Scholar] [CrossRef] [PubMed]
[20] Gao, J., Wong, C., Maar, M. and Park, D. (2021) Reliability of Performing Ultrasound Derived SWE and Fat Fraction in Adult Livers. Clinical Imaging, 80, 424-429. [Google Scholar] [CrossRef] [PubMed]
[21] Zhang, X., Wei, Q., Wu, G., Tang, Q., Pan, X., Chen, G., et al. (2023) Artificial Intelligence—Based Ultrasound Elastography for Disease Evaluation—A Narrative Review. Frontiers in Oncology, 13, Article 1197447. [Google Scholar] [CrossRef] [PubMed]
[22] Shin, B., Jeon, S., Ryu, J. and Kwon, H.J. (2017) Elastography for Portable Ultrasound. Biomedical Engineering Letters, 8, 101-116. [Google Scholar] [CrossRef] [PubMed]

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