米拉贝隆与舍尼亭治疗TURP术后膀胱痉挛安全性与有效性的比较——米拉贝隆治疗膀胱痉挛

A Comparative Analysis of the Safety and Efficacy of Mirabegron versus Tolterodine in the Treatment of Postoperative Bladder Spasm after TURP—Mirabegron for the Treatment of Bladder Spasms

摘要: 目的：比较米拉贝隆与舍尼亭治疗TURP术后膀胱痉挛的安全性与有效性。方法：回顾性收集TURP术后因膀胱痉挛使用米拉贝隆或舍尼亭的患者临床数据各45例，评估米拉贝隆与舍尼亭的有效性以及安全性。结果：米拉贝隆组总有效率为93.33%，高于舍尼亭组的73.33%，差异具有统计学意义(P < 0.05)；米拉贝隆组要求加用止痛类药物率为6.67%，低于舍尼亭组的26.7%。舍尼亭组出现眼干、口干、便秘等不良反应率高于米拉贝隆组(40% vs 12%)，舍尼亭组拔除导尿管后6例患者出现尿潴留，米拉贝隆组无急性尿潴留发生。结论：米拉贝隆治疗TURP术后膀胱痉挛的有效性与安全性似乎均略高于舍尼亭，有较好的临床适用性。

Abstract: Objective: To compare the safety and efficacy of mirabegron and tolterodine in the treatment of bladder spasm after transurethral resection of the prostate (TURP). Methods: The clinical data of 45 patients who used mirabegron and 45 patients who used tolterodine for bladder spasm after TURP were retrospectively collected to evaluate the efficacy and safety of mirabegron and tolterodine. Results: The total effective rate of the mirabegron group was 93.33%, which was higher than that of the tolterodine group (73.33%), and the difference was statistically significant (P < 0.05). The rate of requiring additional analgesic drugs in the mirabegron group was 6.67%, which was lower than that in the tolterodine group (26.7%). The incidence of adverse reactions such as dry eyes, dry mouth, and constipation in the tolterodine group was higher than that in the mirabegron group (40% vs 12%). Six patients in the tolterodine group developed urinary retention after catheter removal, while no acute urinary retention occurred in the mirabegron group. Conclusion: The efficacy and safety of mirabegron in the treatment of bladder spasm after TURP seem to be slightly higher than those of tolterodine, and it has good clinical applicability.