胰岛素抵抗替代指标与2型糖尿病合并骨质疏松的相关性研究
The Correlation between Insulin Resistance Replacement Index and Osteoporosis in Type 2 Diabetes Mellitus
摘要: 目的：探讨2型糖尿病患者胰岛素抵抗替代指标(甘油三酯–葡萄糖指数和胰岛素抵抗代谢评分)与骨质疏松严重程度的相关性研究。方法：纳入387例T2DM患者，根据骨密度分为骨密度正常组(135例)、低骨量组(164例)和骨质疏松组(88例)。收集患者的一般资料和骨密度值，计算甘油三酯–葡萄糖指数(TyG)、胰岛素抵抗代谢评分(METS-IR)。采用单因素与多因素logistic回归方法分析TyG、METS-IR与骨密度之间的关系。结果：合并OP组、低骨量组METSIR、TyG均高于骨密度正常组；合并OP组METS-IR、TyG高于低骨量组；METS-IR、TyG与糖尿病发生骨质疏松的疾病进展呈正相关(p < 0.05)；METS-IR、TyG是2型糖尿病合并骨质疏松的独立影响因素(均p < 0.05)。结论：患者胰岛素抵抗程度越高，患骨质疏松症的风险就越大。
Abstract: Objective: To investigate the correlation between insulin resistance replacement indexes (triglyceride-glucose index and insulin resistance metabolic score) and the severity of osteoporosis in patients with type 2 diabetes. Methods: 387 T2DM patients were included and divided into normal bone mineral density group (135 cases), low bone mass group (164 cases) and osteoporosis group (88 cases) according to BMD. General data and bone mineral density were collected, and triglyceride-glucose index (TyG) and insulin resistance metabolic score (METS-IR) were calculated. Univariate and multivariate logistic regression methods were used to analyze the relationship between TyG, MET-IR and bone mineral density. Results: METSIR and TyG in OP group and low bone mass group were higher than those in normal bone density group. METS-IR and TyG in OP group were higher than those in low bone mass group. METS-IR and TyG were positively correlated with the disease progression of osteoporosis caused by diabetes (p < 0.05); METS-IR and TyG were independent factors of type 2 diabetes mellitus combined with osteoporosis (all p < 0.05). Conclusion: The higher the degree of insulin resistance, the greater the risk of osteoporosis.
文章引用：吴雪, 杨振兴, 韩娇娇, 董幼平. 胰岛素抵抗替代指标与2型糖尿病合并骨质疏松的相关性研究[J]. 临床医学进展, 2025, 15(2): 1620-1626. https://doi.org/10.12677/acm.2025.152518

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