血清SII、TyG、FAR与急性心肌梗死患者冠脉病变严重程度的相关性研究综述

A Review of the Correlation between Serum SII, TyG, FAR and the Severity of Coronary Lesions in Patients with Acute Myocardial Infarction

摘要: 心血管疾病(cardiovascular disease, CVD)是全球发病率和死亡率的主要原因，严重威胁着全球人类的健康。CVD包含疾病有多种其中急性心肌梗死(AMI)是最常见严重危害中老年人群健康的心血管疾病之一，血清甘油三酯葡萄糖指数(triglyceride-glucose index, TyG指数)是胰岛素抵抗(insulin resistance, IR)的一种新型替代指标，为条件受限地区临床决策提供有力依据。有研究指出TyG指数不仅可预测CVD、2型糖尿病的发生发展，还可评估代谢性疾病发生。SII对冠心病患者介入治疗后发生不良心血管事件的预测价值优于传统危险。FAR在预测主要心血管不良事件尤其是合并DM方面比单独用FIB和Alb有更高敏感性和特异性。本文旨在阐述TyG指数与FIB/Alb比值(FAR)、SII在AMI患者中冠脉病变严重程度的发生发展关系，以便更好地了解TyG指数、FIB/Alb比值(FAR)、SII在AMI中的应用价值。

Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and poses a serious threat to human health worldwide. CVD includes a variety of diseases, among which acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that seriously harm the health of middle-aged and elderly people. Serum triglyceride-glucose index (TyG index) is a novel proxy for insulin resistance (IR), which provides a strong basis for clinical decision-making in restricted areas. Some studies have pointed out that TyG index can not only predict the occurrence and development of CVD and type 2 diabetes, but also evaluate the occurrence of metabolic diseases. The predictive value of SII for adverse cardiovascular events in patients with coronary heart disease after interventional therapy is better than that of traditional risk. FAR has higher sensitivity and specificity than FIB and Alb alone in predicting major cardiovascular adverse events, especially with DM. This paper aims to describe the relationship between TyG index, FIB/Alb ratio (FAR) and SII in the severity of coronary lesions in patients with AMI, so as to better understand the application value of TyG index, FIB/Alb ratio (FAR) and SII in AMI.