肥胖、高血压与骨关节炎相关研究进展
Research Progress of Obesity, Hypertension and Osteoarthritis
DOI: 10.12677/acm.2025.152545, PDF,   
作者: 李超哲, 孙炳慧：内蒙古民族大学第二临床医学院，内蒙古 通辽；内蒙古林业总医院骨科，内蒙古 牙克石
关键词: 高血压；肥胖；骨关节炎；Hypertension； Obesity； Osteoarthritis
摘要: 肥胖与高血压等疾病已被确认与骨关节炎(OA)的发病机制有着因果关系。最近的流行病学和临床研究结果证实，脂肪因子通过多种信号通路介导炎症、组织降解和OA发病机制。OA不再被认为只是一种“磨损性”疾病，OA发病机制中代谢相关成分的参与增加了疾病的复杂性。本论文旨在深入探讨肥胖及高血压在骨关节炎的发生与演进中的具体作用。
Abstract: Obesity and hypertension have been confirmed to have a causal relationship with the pathogenesis of osteoarthritis (OA). Recent epidemiological and clinical research results have confirmed that adipokines mediate inflammation, tissue degradation, and the pathogenesis of OA through multiple signaling pathways. OA is no longer considered merely a “wear and tear” disease; the involvement of metabolism-related components in the pathogenesis of OA has increased the complexity of the disease. This paper aims to deeply explore the specific roles of obesity and hypertension in the occurrence and progression of osteoarthritis.
文章引用：李超哲, 孙炳慧. 肥胖、高血压与骨关节炎相关研究进展[J]. 临床医学进展, 2025, 15(2): 1859-1863. https://doi.org/10.12677/acm.2025.152545

参考文献

[1] Bortoluzzi, A., Furini, F. and Scirè, C.A. (2018) Osteoarthritis and Its Management—Epidemiology, Nutritional Aspects and Environmental Factors. Autoimmunity Reviews, 17, 1097-1104. [Google Scholar] [CrossRef] [PubMed]
[2] Coaccioli, S., Sarzi-Puttini, P., Zis, P., Rinonapoli, G. and Varrassi, G. (2022) Osteoarthritis: New Insight on Its Pathophysiology. Journal of Clinical Medicine, 11, Article 6013. [Google Scholar] [CrossRef] [PubMed]
[3] Lee, J.Y., Han, K., Park, Y.G. and Park, S. (2019) Association of Leg Muscle Symmetry with Knee Osteoarthritis. Clinical Rheumatology, 38, 3549-3556. [Google Scholar] [CrossRef] [PubMed]
[4] Ozeki, N., Koga, H. and Sekiya, I. (2022) Degenerative Meniscus in Knee Osteoarthritis: From Pathology to Treatment. Life, 12, Article 603. [Google Scholar] [CrossRef] [PubMed]
[5] Schulze-Tanzil, G. (2019) Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis. Cells, 8, Article 990. [Google Scholar] [CrossRef] [PubMed]
[6] Donell, S. (2019) Subchondral Bone Remodelling in Osteoarthritis. EFORT Open Reviews, 4, 221-229. [Google Scholar] [CrossRef] [PubMed]
[7] Allen, K.D., Thoma, L.M. and Golightly, Y.M. (2022) Epidemiology of Osteoarthritis. Osteoarthritis and Cartilage, 30, 184-195. [Google Scholar] [CrossRef] [PubMed]
[8] Cui, A., Li, H., Wang, D., Zhong, J., Chen, Y. and Lu, H. (2020) Global, Regional Prevalence, Incidence and Risk Factors of Knee Osteoarthritis in Population-Based Studies. EClinicalMedicine, 29, Article 100587. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, H., Cheng, Y., Shao, D., Chen, J., Sang, Y., Gui, T., et al. (2016) Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis. Evidence-Based Complementary and Alternative Medicine, 2016, Article ID: 7242478. [Google Scholar] [CrossRef] [PubMed]
[10] Liu, S., Zhu, W., Chen, B., Chen, Y. and Ni, G. (2020) Bidirectional Association between Metabolic Syndrome and Osteoarthritis: A Meta-Analysis of Observational Studies. Diabetology & Metabolic Syndrome, 12, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[11] Pan, F., Tian, J., Mattap, S.M., Cicuttini, F. and Jones, G. (2019) Association between Metabolic Syndrome and Knee Structural Change on MRI. Rheumatology, 59, 185-193. [Google Scholar] [CrossRef] [PubMed]
[12] He, Y., Li, Z., Alexander, P.G., Ocasio-Nieves, B.D., Yocum, L., Lin, H., et al. (2020) Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models. Biology, 9, Article 194. [Google Scholar] [CrossRef] [PubMed]
[13] Coggon, D., Reading, I., Croft, P., McLaren, M., Barrett, D. and Cooper, C. (2001) Knee Osteoarthritis and Obesity. International Journal of Obesity, 25, 622-627. [Google Scholar] [CrossRef] [PubMed]
[14] Chen, L., Zheng, J.J.Y., Li, G., Yuan, J., Ebert, J.R., Li, H., et al. (2020) Pathogenesis and Clinical Management of Obesity-Related Knee Osteoarthritis: Impact of Mechanical Loading. Journal of Orthopaedic Translation, 24, 66-75. [Google Scholar] [CrossRef] [PubMed]
[15] Hikida, M., Nakajima, M. and Nakata, K. (2021) Cyclic Compressive Mechanical Loading on Three Dimensional Cultured Tissue of Human Chondrocytes Synergistically Upregulates MMP-3 Gene Expression with IL-1β. Journal of Osaka Dental University, 55, 91-98. [Google Scholar] [CrossRef] 
[16] Hirose, N., Okamoto, Y., Yanoshita, M., Asakawa, Y., Sumi, C., Takano, M., et al. (2020) Protective Effects of Cilengitide on Inflammation in Chondrocytes under Excessive Mechanical Stress. Cell Biology International, 44, 966-974. [Google Scholar] [CrossRef] [PubMed]
[17] Yanoshita, M., Hirose, N., Okamoto, Y., Sumi, C., Takano, M., Nishiyama, S., et al. (2018) Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression via FAK-MAPK Signaling in Chondrocytes. Inflammation, 41, 1621-1630. [Google Scholar] [CrossRef] [PubMed]
[18] Gløersen, M., Steen Pettersen, P., Neogi, T., Jafarzadeh, S.R., Vistnes, M., Thudium, C.S., et al. (2022) Associations of Body Mass Index with Pain and the Mediating Role of Inflammatory Biomarkers in People with Hand Osteoarthritis. Arthritis & Rheumatology, 74, 810-817. [Google Scholar] [CrossRef] [PubMed]
[19] Wang, T. and He, C. (2018) Pro-inflammatory Cytokines: The Link between Obesity and Osteoarthritis. Cytokine & Growth Factor Reviews, 44, 38-50. [Google Scholar] [CrossRef] [PubMed]
[20] Purdy, J.C. and Shatzel, J.J. (2020) The Hematologic Consequences of Obesity. European Journal of Haematology, 106, 306-319. [Google Scholar] [CrossRef] [PubMed]
[21] Sun, A.R., Panchal, S.K., Friis, T., Sekar, S., Crawford, R., Brown, L., et al. (2017) Obesity-Associated Metabolic Syndrome Spontaneously Induces Infiltration of Pro-Inflammatory Macrophage in Synovium and Promotes Osteoarthritis. PLOS ONE, 12, e0183693. [Google Scholar] [CrossRef] [PubMed]
[22] Liu, B., Zhang, M., Zhao, J., Zheng, M. and Yang, H. (2018) Imbalance of M1/M2 Macrophages Is Linked to Severity Level of Knee Osteoarthritis. Experimental and Therapeutic Medicine, 16, 5009-5014. [Google Scholar] [CrossRef] [PubMed]
[23] Gu, X., Wang, L., Liu, S. and Shan, T. (2023) Adipose Tissue Adipokines and Lipokines: Functions and Regulatory Mechanism in Skeletal Muscle Development and Homeostasis. Metabolism, 139, Article 155379. [Google Scholar] [CrossRef] [PubMed]
[24] Xie, C. and Chen, Q. (2019) Adipokines: New Therapeutic Target for Osteoarthritis? Current Rheumatology Reports, 21, Article No. 71. [Google Scholar] [CrossRef] [PubMed]
[25] Yan, M., Zhang, J., Yang, H. and Sun, Y. (2018) The Role of Leptin in Osteoarthritis. Medicine, 97, e0257. [Google Scholar] [CrossRef] [PubMed]
[26] Lambova, S.N., Batsalova, T., Moten, D., Stoyanova, S., Georgieva, E., Belenska-Todorova, L., et al. (2021) Serum Leptin and Resistin Levels in Knee Osteoarthritis—Clinical and Radiologic Links: Towards Precise Definition of Metabolic Type Knee Osteoarthritis. Biomedicines, 9, Article 1019. [Google Scholar] [CrossRef] [PubMed]
[27] Min, S., Shi, T., Han, X., Chen, D., Xu, Z., Shi, D., et al. (2020) Serum Levels of Leptin, Osteopontin, and Sclerostin in Patients with and without Knee Osteoarthritis. Clinical Rheumatology, 40, 287-294. [Google Scholar] [CrossRef] [PubMed]
[28] Kroon, F.P.B., Veenbrink, A.I., de Mutsert, R., Visser, A.W., van Dijk, K.W., le Cessie, S., et al. (2019) The Role of Leptin and Adiponectin as Mediators in the Relationship between Adiposity and Hand and Knee Osteoarthritis. Osteoarthritis and Cartilage, 27, 1761-1767. [Google Scholar] [CrossRef] [PubMed]
[29] Dumond, H., Presle, N., Terlain, B., Mainard, D., Loeuille, D., Netter, P., et al. (2003) Evidence for a Key Role of Leptin in Osteoarthritis. Arthritis & Rheumatism, 48, 3118-3129. [Google Scholar] [CrossRef] [PubMed]
[30] Presle, N., Pottie, P., Dumond, H., Guillaume, C., Lapicque, F., Pallu, S., et al. (2006) Differential Distribution of Adipokines between Serum and Synovial Fluid in Patients with Osteoarthritis. Contribution of Joint Tissues to Their Articular Production. Osteoarthritis and Cartilage, 14, 690-695. [Google Scholar] [CrossRef] [PubMed]
[31] Orellana, C., Calvet, J., Berenguer-Llergo, A., Albiñana, N., García Manrique, M., Galisteo Lencastre, C., et al. (2020) Synovial Adiponectin Was More Associated with Clinical Severity than Synovial Leptin in Women with Knee Osteoarthritis. CARTILAGE, 13, 1675S-1683S. [Google Scholar] [CrossRef] [PubMed]
[32] Han, W., Aitken, D., Zheng, S., Wang, B., Wluka, A.E., Zhu, Z., et al. (2019) Higher Serum Levels of Resistin Are Associated with Knee Synovitis and Structural Abnormalities in Patients with Symptomatic Knee Osteoarthritis. Journal of the American Medical Directors Association, 20, 1242-1246. [Google Scholar] [CrossRef] [PubMed]
[33] Alissa, E.M., Alzughaibi, L.S. and Marzouki, Z.M. (2020) Relationship between Serum Resistin, Body Fat and Inflammatory Markers in Females with Clinical Knee Osteoarthritis. The Knee, 27, 45-50. [Google Scholar] [CrossRef] [PubMed]
[34] Ching, K., Houard, X., Berenbaum, F. and Wen, C. (2021) Hypertension Meets Osteoarthritis—Revisiting the Vascular Aetiology Hypothesis. Nature Reviews Rheumatology, 17, 533-549. [Google Scholar] [CrossRef] [PubMed]
[35] Niu, J., Clancy, M., Aliabadi, P., Vasan, R. and Felson, D.T. (2017) Metabolic Syndrome, Its Components, and Knee Osteoarthritis: The Framingham Osteoarthritis Study. Arthritis & Rheumatology, 69, 1194-1203. [Google Scholar] [CrossRef] [PubMed]
[36] Findlay, D.M. (2007) Vascular Pathology and Osteoarthritis. Rheumatology, 46, 1763-1768. [Google Scholar] [CrossRef] [PubMed]
[37] Shi, X. and Schlenk, E.A. (2022) Association of Hypertension with Knee Pain Severity among People with Knee Osteoarthritis. Pain Management Nursing, 23, 135-141. [Google Scholar] [CrossRef] [PubMed]
[38] Lo, K., Au, M., Ni, J. and Wen, C. (2022) Association between Hypertension and Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies. Journal of Orthopaedic Translation, 32, 12-20. [Google Scholar] [CrossRef] [PubMed]

为你推荐