生活方式对多囊卵巢综合征影响的研究进展
Advances in the Study of the Effect of Lifestyle on Polycystic Ovary Syndrome
DOI: 10.12677/acm.2025.152555, PDF,   
作者: 李云云：黑龙江中医药大学研究生院，黑龙江 哈尔滨；孙 淼*：黑龙江中医药大学附属第一医院妇科，黑龙江 哈尔滨
关键词: 多囊卵巢综合征；生活方式；运动；饮食；心理状态；PCOS； Lifestyle； Exercise； Diet； Psychological State
摘要: 多囊卵巢综合征(polycystic ovary syndrome, PCOS)是以高雄激素血症、排卵障碍和月经紊乱为主要表现的临床综合征，也是严重影响女性生殖、代谢及心理健康的常见妇科内分泌疾病。PCOS的发病因素诸多，其中缺乏体育锻炼、不正确的饮食方式、心理障碍等不良生活方式亦是诱发PCOS的重要影响因素。因此，对PCOS患者进行生活方式干预有助于控制PCOS和提高孕妇的生活质量。目前的治疗指南倡导将改变生活方式作为PCOS的一线治疗，希望通过饮食及运动代替药物性治疗。本文通过PCOS的发病机制及从运动、饮食、心理状态等几个方面对生活方式对PCOS影响的研究进展作一综述。
Abstract: Polycystic ovary syndrome (PCOS) is a clinical syndrome characterized by hyperandrogenism, ovulation disorders, and menstrual disorders, and is also a common gynecological endocrine disease that seriously affects female reproductive, metabolic, and mental health. There are many factors for the pathogenesis of PCOS, among which lack of physical exercise, incorrect diet, psychological disorders and other unhealthy lifestyles are also important influencing factors for PCOS. Therefore, lifestyle interventions for patients with PCOS can help control PCOS and improve the quality of life of pregnant women. Current treatment guidelines advocate lifestyle modification as the first-line treatment for PCOS, with the hope of replacing pharmacological therapy with diet and exercise. This article reviews the pathogenesis of PCOS and the research progress on the influence of lifestyle on PCOS from the aspects of exercise, diet, and psychological state.
文章引用：李云云, 孙淼. 生活方式对多囊卵巢综合征影响的研究进展[J]. 临床医学进展, 2025, 15(2): 1952-1957. https://doi.org/10.12677/acm.2025.152555

参考文献

[1] Patel, S. (2018) Polycystic Ovary Syndrome (PCOS), an Inflammatory, Systemic, Lifestyle Endocrinopathy. The Journal of Steroid Biochemistry and Molecular Biology, 182, 27-36. [Google Scholar] [CrossRef] [PubMed]
[2] Stener-Victorin, E., Teede, H., Norman, R.J., Legro, R., Goodarzi, M.O., Dokras, A., et al. (2024) Polycystic Ovary Syndrome. Nature Reviews Disease Primers, 10, Article No. 27. [Google Scholar] [CrossRef] [PubMed]
[3] Teede, H.J., Joham, A.E., Paul, E., Moran, L.J., Loxton, D., Jolley, D., et al. (2013) Longitudinal Weight Gain in Women Identified with Polycystic Ovary Syndrome: Results of an Observational Study in Young Women. Obesity, 21, 1526-1532. [Google Scholar] [CrossRef] [PubMed]
[4] Lim, S.S., Hutchison, S.K., Van Ryswyk, E., Norman, R.J., Teede, H.J. and Moran, L.J. (2019) Lifestyle Changes in Women with Polycystic Ovary Syndrome. Cochrane Database of Systematic Reviews, 2019, CD007506. [Google Scholar] [CrossRef] [PubMed]
[5] Kazemi, M., Kim, J.Y., Wan, C., Xiong, J.D., Michalak, J., Xavier, I.B., et al. (2022) Comparison of Dietary and Physical Activity Behaviors in Women with and without Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of 39471 Women. Human Reproduction Update, 28, 910-955. [Google Scholar] [CrossRef] [PubMed]
[6] Moran, L.J., Ko, H., Misso, M., Marsh, K., Noakes, M., Talbot, M., et al. (2013) Dietary Composition in the Treatment of Polycystic Ovary Syndrome: A Systematic Review to Inform Evidence-Based Guidelines. Journal of the Academy of Nutrition and Dietetics, 113, 520-545. [Google Scholar] [CrossRef] [PubMed]
[7] Goodarzi, M.O., Dumesic, D.A., Chazenbalk, G. and Azziz, R. (2011) Polycystic Ovary Syndrome: Etiology, Pathogenesis and Diagnosis. Nature Reviews Endocrinology, 7, 219-231. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, J., Wu, D., Guo, H. and Li, M. (2019) Hyperandrogenemia and Insulin Resistance: The Chief Culprit of Polycystic Ovary Syndrome. Life Sciences, 236, Article ID: 116940. [Google Scholar] [CrossRef] [PubMed]
[9] Xiang, Y., Wang, H., Ding, H., Xu, T., Liu, X., Huang, Z., et al. (2023) Hyperandrogenism Drives Ovarian Inflammation and Pyroptosis: A Possible Pathogenesis of PCOS Follicular Dysplasia. International Immunopharmacology, 125, Article ID: 111141. [Google Scholar] [CrossRef] [PubMed]
[10] Laganà, A.S., Garzon, S., Casarin, J., Franchi, M. and Ghezzi, F. (2018) Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends in Endocrinology & Metabolism, 29, 768-780. [Google Scholar] [CrossRef] [PubMed]
[11] Rutsch, A., Kantsjö, J.B. and Ronchi, F. (2020) The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Frontiers in Immunology, 11, Article ID: 604179. [Google Scholar] [CrossRef] [PubMed]
[12] Zhai, Y. and Pang, Y. (2022) Systemic and Ovarian Inflammation in Women with Polycystic Ovary Syndrome. Journal of Reproductive Immunology, 151, Article ID: 103628. [Google Scholar] [CrossRef] [PubMed]
[13] 葛亚杰, 徐文, 关诗敏, 等. 多囊卵巢综合征病因及其发病机制的研究进展[J]. 吉林大学学报(医学版), 2024, 50(1): 288-294.
[14] Hagan, T., Cortese, M., Rouphael, N., Boudreau, C., Linde, C., Maddur, M.S., et al. (2019) Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell, 178, 1313-1328.e13. [Google Scholar] [CrossRef] [PubMed]
[15] Tremellen, K. and Pearce, K. (2012) Dysbiosis of Gut Microbiota (DOGMA)—A Novel Theory for the Development of Polycystic Ovarian Syndrome. Medical Hypotheses, 79, 104-112. [Google Scholar] [CrossRef] [PubMed]
[16] Zeng, B., Lai, Z., Sun, L., Zhang, Z., Yang, J., Li, Z., et al. (2019) Structural and Functional Profiles of the Gut Microbial Community in Polycystic Ovary Syndrome with Insulin Resistance (IR-PCOS): A Pilot Study. Research in Microbiology, 170, 43-52. [Google Scholar] [CrossRef] [PubMed]
[17] Shan, D., Han, J., Cai, Y., Zou, L., Xu, L. and Shen, Y. (2021) Reproductive Health in First-Degree Relatives of Patients with Polycystic Ovary Syndrome: A Review and Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism, 107, 273-295. [Google Scholar] [CrossRef] [PubMed]
[18] Hayes, M.G., Urbanek, M., Ehrmann, D.A., Armstrong, L.L., Lee, J.Y., Sisk, R., et al. (2016) Correction: Corrigendum: Genome-Wide Association of Polycystic Ovary Syndrome Implicates Alterations in Gonadotropin Secretion in European Ancestry Populations. Nature Communications, 7, Article No. 10762. [Google Scholar] [CrossRef] [PubMed]
[19] Stepto, N.K., Patten, R.K., Tassone, E.C., Misso, M.L., Brennan, L., Boyle, J., et al. (2019) Exercise Recommendations for Women with Polycystic Ovary Syndrome: Is the Evidence Enough? Sports Medicine, 49, 1143-1157. [Google Scholar] [CrossRef] [PubMed]
[20] Teede, H.J., Misso, M.L., Costello, M.F., Dokras, A., Laven, J., Moran, L., et al. (2018) Recommendations from the International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Human Reproduction, 33, 1602-1618. [Google Scholar] [CrossRef] [PubMed]
[21] Costa, E.C., De Sá, J.C.F., Stepto, N.K., Costa, I.B.B., Farias-Junior, L.F., Moreira, S.D.N.T., et al. (2018) Aerobic Training Improves Quality of Life in Women with Polycystic Ovary Syndrome. Medicine & Science in Sports & Exercise, 50, 1357-1366. [Google Scholar] [CrossRef] [PubMed]
[22] Kite, C., Lahart, I.M., Afzal, I., Broom, D.R., Randeva, H., Kyrou, I., et al. (2019) Exercise, or Exercise and Diet for the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Systematic Reviews, 8, Article No. 51. [Google Scholar] [CrossRef] [PubMed]
[23] Cassar, S., Misso, M.L., Hopkins, W.G., Shaw, C.S., Teede, H.J. and Stepto, N.K. (2016) Insulin Resistance in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Euglycaemic-Hyperinsulinaemic Clamp Studies. Human Reproduction, 31, 2619-2631. [Google Scholar] [CrossRef] [PubMed]
[24] Lim, S.S., Davies, M.J., Norman, R.J. and Moran, L.J. (2012) Overweight, Obesity and Central Obesity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Human Reproduction Update, 18, 618-637. [Google Scholar] [CrossRef] [PubMed]
[25] Patten, R.K., Boyle, R.A., Moholdt, T., Kiel, I., Hopkins, W.G., Harrison, C.L., et al. (2020) Exercise Interventions in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Frontiers in Physiology, 11, Article No. 606. [Google Scholar] [CrossRef] [PubMed]
[26] Conway, G., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Franks, S., Gambineri, A., et al. (2014) The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology. European Journal of Endocrinology, 171, P1-P29. [Google Scholar] [CrossRef] [PubMed]
[27] Barrea, L., Marzullo, P., Muscogiuri, G., Di Somma, C., Scacchi, M., Orio, F., et al. (2018) Source and Amount of Carbohydrate in the Diet and Inflammation in Women with Polycystic Ovary Syndrome. Nutrition Research Reviews, 31, 291-301. [Google Scholar] [CrossRef] [PubMed]
[28] Haj‐Husein, I., Tukan, S. and Alkazaleh, F. (2015) The Effect of Marjoram (Origanum majorana) Tea on the Hormonal Profile of Women with Polycystic Ovary Syndrome: A Randomised Controlled Pilot Study. Journal of Human Nutrition and Dietetics, 29, 105-111. [Google Scholar] [CrossRef] [PubMed]
[29] Azadi‐Yazdi, M., Karimi‐Zarchi, M., Salehi‐Abargouei, A., Fallahzadeh, H. and Nadjarzadeh, A. (2016) Effects of Dietary Approach to Stop Hypertension Diet on Androgens, Antioxidant Status and Body Composition in Overweight and Obese Women with Polycystic Ovary Syndrome: A Randomised Controlled Trial. Journal of Human Nutrition and Dietetics, 30, 275-283. [Google Scholar] [CrossRef] [PubMed]
[30] Che, X., Chen, Z., Liu, M. and Mo, Z. (2021) Dietary Interventions: A Promising Treatment for Polycystic Ovary Syndrome. Annals of Nutrition and Metabolism, 77, 313-323. [Google Scholar] [CrossRef] [PubMed]
[31] Marzouk, T.M. and Sayed Ahmed, W.A. (2015) Effect of Dietary Weight Loss on Menstrual Regularity in Obese Young Adult Women with Polycystic Ovary Syndrome. Journal of Pediatric and Adolescent Gynecology, 28, 457-461. [Google Scholar] [CrossRef] [PubMed]
[32] Kolhe, J.V., Chhipa, A.S., Butani, S., Chavda, V. and Patel, S.S. (2021) PCOS and Depression: Common Links and Potential Targets. Reproductive Sciences, 29, 3106-3123. [Google Scholar] [CrossRef] [PubMed]

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